New Delhi metallo-beta-lactamase 1 catalyzes avibactam and aztreonam hydrolysis von Lohans, C, Brem, J, Schofield, C

New Delhi metallo-β-lactamase-1 catalyses avibactam and aztreonam hydrolysis. von Lohans, C, Brem, J, Schofield, C

Analysis of β-lactone formation by clinically observed carbapenemases informs on a novel antibiotic resistance mechanism von Aertker, K, Chan, H, Lohans, C, Schofield, C

Inhibition of a viral prolyl hydroxylase von Langley, G, Abboud, M, Lohans, C, Schofield, C

Roles of 2-oxoglutarate oxygenases and isopenicillin N synthase in ß-lactam biosynthesis von Rabe, P, Kamps, J, Schofield, C, Lohans, C

Crotonases: Nature’s exceedingly convertible catalysts von Lohans, C, Wang, D, Wang, J, Hamed, R, Schofield, C

A Fluorescence‐based assay for screening β‐lactams targeting the Mycobacterium tuberculosis transpeptidase LdtMt2 von De Munnik, M, Lohans, C, Langley, G, Bon, C, Brem, J, Schofield, C

A new mechanism for β-lactamases: Class D enzymes degrade 1β-methyl carbapenems through lactone formation von Lohans, C, van Groesen, E, Kumar, K, Tooke, C, Spencer, J, Paton, R, Brem, J, Schofield, C

Mechanistic insights into β-lactamase-catalysed carbapenem degradation through product characterisation von Lohans, C, Freeman, E, Van Groesen, E, Tooke, C, Hinchliffe, P, Spencer, J, Brem, J, Schofield, C

NMR-filtered virtual screening leads to non-metal chelating metallo-β-lactamase inhibitors von Li, G, Abboud, M, Brem, J, Someya, H, Lohans, C, Yang, S, Spencer, J, Wareham, D, McDonough, M, Schofield, C

Structural and stereoelectronic insights into oxygenase catalyzed formation of ethylene from 2-oxoglutarate von Zhang, Z, Smart, T, Choi, H, Hardy, F, Lohans, C, Abboud, M, Richardson, M, Paton, R, McDonough, M, Schofield, C

Selective inhibitors of a human prolyl hydroxylase (OGFOD1) involved in ribosomal decoding von Thinnes, C, Lohans, C, Abboud, M, Yeh, T, Tumber, A, Nowak, R, Attwood, M, Cockman, M, Oppermann, U, Loenarz, C, Schofield, C

Structure-Based in Silico Screening Identifies a Potent Ebolavirus Inhibitor from a Traditional Chinese Medicine Library von Shaikh, F, Zhao, Y, Alvarez, L, Iliopoulou, M, Lohans, C, Schofield, C, Padilla-Parra, S, Siu, S, Fry, E, Ren, J, Stuart, D

Structural/mechanistic insights into the efficacy of nonclassical β-lactamase inhibitors against extensively drug resistant Stenotrophomonas maltophilia clinical isolates von Calvopiña, K, Hinchliffe, P, Brem, J, Heesom, K, Johnson, S, Cain, R, Lohans, C, Fishwick, C, Schofield, C, Spencer, J, Avison, M

13 C-Carbamylation as a mechanistic probe for the inhibition of class D β-lactamases by avibactam and halide ions von Lohans, C, Yang, D, Jorgensen, C, Cahill, S, Clifton, I, McDonough, M, Oswin, H, Spenser, J, Domene, C, Claridge, T, Brem, J, Schofield, C

Cyclic Boronates Inhibit All Classes of β-Lactamase. von Cahill, S, Cain, R, Wang, D, Lohans, C, Wareham, D, Oswin, H, Mohammed, J, Spencer, J, Fishwick, C, McDonough, M, Schofield, C, Brem, J

Studies on the inhibition of AmpC and other β-lactamases by cyclic boronates von Cahill, S, Tyrrell, J, Navratilovac, I, Calvopiña, K, Robinson, S, Lohans, C, McDonough, M, Cain, R, Fishwick, C, Avison, M, Walsh, T, Schofield, C, Brem, J

Crystallographic analyses of isoquinoline complexes reveal a new mode of metallo-β-lactamase inhibition von Li, G, Brem, J, Lesniak, R, Abboud, M, Lohans, C, Clifton, I, Yang, S, Jiménez-Castellanos, J, Avison, M, Spencer, J, McDonough, M, Schofield, C

Faropenem reacts with serine and metallo-β-lactamases to give multiple products von Lucic, A, Hinchliffe, P, Malla, T, Tooke, C, Brem, J, Calvopina, K, Lohans, C, Rabe, P, McDonough, M, Armistead, T, Orville, A, Spencer, J, Schofield, C

Non‐Hydrolytic β‐Lactam Antibiotic Fragmentation by l,d‐Transpeptidases and Serine β‐Lactamase Cysteine Variants von Lohans, C, Chan, H, Malla, T, Kumar, K, Kamps, J, McArdle, D, Van Groesen, E, De Munnik, M, Tooke, C, Spencer, J, Paton, R, Brem, J, Schofield, C