CHK1 inhibition as a strategy for targeting fanconi anemia (FA) DNA repair pathway deficient tumors 由 Look A Thomas, Sidi Samuel, Kennedy Richard D, Chen Clark C, D'Andrea Alan

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Retinoic acid rewires the adrenergic core regulatory circuitry of childhood neuroblastoma 由 Zimmerman, Mark W, Durbin, Adam D, He, Shuning, Oppel, Felix, Shi, Hui, Tao, Ting, Li, Zhaodong, Berezovskaya, Alla, Liu, Yu, Zhang, Jinghui, Young, Richard A, Abraham, Brian J, Look, A Thomas

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The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia 由 Mansour, Marc R., Sanda, Takaomi, Lawton, Lee N., Li, Xiaoyu, Kreslavsky, Taras, Novina, Carl D., Brand, Marjorie, Gutierrez, Alejandro, Kelliher, Michelle A., Jamieson, Catriona H. M., von Boehmer, Harald, Young, Richard A., Look, A. Thomas

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Core Transcriptional Regulatory Circuit Controlled by the TAL1 Complex in Human T Cell Acute Lymphoblastic Leukemia 由 Sanda, Takaomi, Lawton, Lee N., Barrasa, M. Inmaculada, Fan, Zi Peng, Kohlhammer, Holger, Gutierrez, Alejandro, Ma, Wenxue, Tatarek, Jessica, Ahn, Yebin, Kelliher, Michelle A., Jamieson, Catriona H. M., Staudt, Louis M., Young, Richard A., Look, A. Thomas

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LIN28B regulates transcription and potentiates MYCN-induced neuroblastoma through binding to ZNF143 at target gene promotors 由 Tao, Ting, Shi, Hui, Mariani, Luca, Abraham, Brian J, Durbin, Adam D, Zimmerman, Mark W, Powers, John T, Missios, Pavlos, Ross, Kenneth N, Perez-Atayde, Antonio R, Bulyk, Martha L, Young, Richard A, Daley, George Q, Look, A Thomas

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LIN28B regulates transcription and potentiates MYCN-induced neuroblastoma through binding to ZNF143 at target gene promotors 由 Tao, Ting, Shi, Hui, Mariani, Luca, Abraham, Brian J., Durbin, Adam D., Zimmerman, Mark W., Powers, John T., Missios, Pavlos, Ross, Kenneth N., Perez-Atayde, Antonio R., Bulyk, Martha L., Young, Richard A., Daley, George Q., Look, A. Thomas

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Small genomic insertions form enhancers that misregulate oncogenes 由 Hnisz, Denes, Li, Zhaodong, Weichert-Leahey, Nina, Rahman, Sunniyat, Liu, Yu, Etchin, Julia, Li, Benshang, Shen, Shuhong, Zhang, Jinghui, Look, A. Thomas, Mansour, Marc R., Abraham, Brian Joseph, Weintraub, Abraham Selby, Kwiatkowski, Nick, Li, Charles Han, Lee, Tong Ihn, Young, Richard A.

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Aberrant AKT activation drives well-differentiated liposarcoma 由 Gutierrez, Alejandro, Snyder, Eric, Marino-Enriquez, Adrian, Zhang, Yi-Xiang, Sioletic, Stefano, Kozakewich, Elena, Grebliunaite, Ruta, Ou, Wen-bin, Sicinska, Ewa, Raut, Chandrajit P., Demetri, George D., Perez-Atayde, Antonio R., Wagner, Andrew J., Fletcher, Jonathan A., Fletcher, Christopher D. M., Look, A. Thomas

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Activation of the LMO2 oncogene through a somatically acquired neomorphic promoter in T-cell acute lymphoblastic leukemia 由 Rahman, Sunniyat, Magnussen, Michael, León, Theresa E., Farah, Nadine, Li, Zhaodong, Alapi, Krisztina Z., Mitchell, Rachel J., Naughton, Tom, Fielding, Adele K., Pizzey, Arnold, Bustraan, Sophia, Popa, Teodora, Pike-Overzet, Karin, Garcia-Perez, Laura, Gale, Rosemary E., Linch, David C., Staal, Frank J. T., Look, A. Thomas, Mansour, Marc R., Abraham, Brian Joseph, Allen, Christopher D, Young, Richard A.

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Targeting transcription regulation in cancer with a covalent CDK7 inhibitor 由 Kwiatkowski, Nicholas P., Zhang, Tinghu, Rahl, Peter B., Abraham, Brian J., Reddy, Jessica, Ficarro, Scott B., Dastur, Anahita, Amzallag, Arnaud, Ramaswamy, Sridhar, Tesar, Bethany, Jenkins, Catherine E., Hannett, Nancy M., McMillin, Douglas, Sanda, Takaomi, Sim, Taebo, Kim, Nam Doo, Look, A. Thomas, Mitsiades, Constantine S., Weng, Andrew P., Brown, Jennifer R., Benes, Cyril H., Marto, Jarrod A., Young, Richard A., Gray, Nathanael S.

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JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia 由 Mansour, Marc R., He, Shuning, Li, Zhaodong, Lobbardi, Riadh, Abraham, Brian J., Hug, Clemens, Rahman, Sunniyat, Leon, Theresa E., Kuang, You-Yi, Zimmerman, Mark W., Blonquist, Traci, Gjini, Evisa, Gutierrez, Alejandro, Tang, Qin, Garcia-Perez, Laura, Pike-Overzet, Karin, Anders, Lars, Berezovskaya, Alla, Zhou, Yi, Zon, Leonard I., Neuberg, Donna, Fielding, Adele K., Staal, Frank J.T., Langenau, David M., Sanda, Takaomi, Look, A. Thomas, Young, Richard A.

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Cross-Cohort Analysis Identifies a TEAD4–MYCN Positive Feedback Loop as the Core Regulatory Element of High-Risk Neuroblastoma 由 Rajbhandari, Presha, Lopez, Gonzalo, Capdevila, Claudia, Salvatori, Beatrice, Yu, Jiyang, Rodriguez-Barrueco, Ruth, Martinez, Daniel, Yarmarkovich, Mark, Weichert-Leahey, Nina, Alvarez, Mariano J., Iyer, Archana, Harenza, Jo Lynne, Oldridge, Derek, De Preter, Katleen, Koster, Jan, Asgharzadeh, Shahab, Seeger, Robert C., Wei, Jun S., Khan, Javed, Vandesompele, Jo, Mestdagh, Pieter, Versteeg, Rogier, Look, A. Thomas, Iavarone, Antonio, Lasorella, Anna, Silva, Jose M., Maris, John M., Califano, Andrea, Abraham, Brian Joseph, Young, Richard A.

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