Successes and Hurdles in Stem Cells Application and Production for Brain Transplantation by Daniel Henriques, Daniel Henriques, Ricardo Moreira, Ricardo Moreira, Jens Schwamborn, Luís Pereira de Almeida, Luís Pereira de Almeida, Luís Pereira de Almeida, Liliana S. Mendonça, Liliana S. Mendonça

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Editorial: Gene therapy 2.0: Biotechnology for circuit engineering and complex therapeutic approaches by Luís Quintino, Luís Pereira de Almeida, Cecilia Lundberg

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Mannose and Lactobionic Acid in Nasal Vaccination: Enhancing Antigen Delivery via C-Type Lectin Receptors by Mariana Colaço, Maria T. Cruz, Luís Pereira de Almeida, Olga Borges

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Brain-targeted drug delivery - nanovesicles directed to specific brain cells by brain-targeting ligands by Ricardo Moreira, Clévio Nóbrega, Luís Pereira de Almeida, Liliana Mendonça

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Fluoxetine induces proliferation and inhibits differentiation of hypothalamic neuroprogenitor cells in vitro. by Lígia Sousa-Ferreira, Célia Aveleira, Mariana Botelho, Ana Rita Álvaro, Luís Pereira de Almeida, Cláudia Cavadas

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Silencing mutant ataxin-3 rescues motor deficits and neuropathology in Machado-Joseph disease transgenic mice. by Clévio Nóbrega, Isabel Nascimento-Ferreira, Isabel Onofre, David Albuquerque, Hirokazu Hirai, Nicole Déglon, Luís Pereira de Almeida

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Graft-derived neurons and bystander effects are maintained for six months after human iPSC-derived NESC transplantation in mice’s cerebella by Liliana S. Mendonça, Daniel Henriques, Vanessa Fernandes, Ricardo Moreira, João Brás, Sónia Duarte, Jens C. Schwamborn, Luís Pereira de Almeida

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Proliferative hypothalamic neurospheres express NPY, AGRP, POMC, CART and Orexin-A and differentiate to functional neurons. by Lígia Sousa-Ferreira, Ana Rita Álvaro, Célia Aveleira, Magda Santana, Inês Brandão, Sebastian Kügler, Luís Pereira de Almeida, Cláudia Cavadas

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Fourier Transform Infrared Spectroscopy Analysis as a Tool to Address Aβ Impact on Extracellular Vesicles by Margarida Vaz, Tânia Soares Martins, Kevin Leandro, Luís Pereira de Almeida, Odete A. B. da Cruz e Silva, Alexandra Nunes, Ana Gabriela Henriques

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Simple and Fast SEC-Based Protocol to Isolate Human Plasma-Derived Extracellular Vesicles for Transcriptional Research by Laetitia S. Gaspar, Magda M. Santana, Carina Henriques, Maria M. Pinto, Teresa M. Ribeiro-Rodrigues, Henrique Girão, Rui Jorge Nobre, Luís Pereira de Almeida

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The blood-brain barrier is disrupted in Machado-Joseph disease/spinocerebellar ataxia type 3: evidence from transgenic mice and human post-mortem samples by Diana Duarte Lobo, Rui Jorge Nobre, Catarina Oliveira Miranda, Dina Pereira, João Castelhano, José Sereno, Arnulf Koeppen, Miguel Castelo-Branco, Luís Pereira de Almeida

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Safety profile of the intravenous administration of brain-targeted stable nucleic acid lipid particles by Mariana Conceição, Liliana Mendonça, Clévio Nóbrega, Célia Gomes, Pedro Costa, Hirokazu Hirai, João Nuno Moreira, Maria C. Lima, N. Manjunath, Luís Pereira de Almeida

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Establishment and characterization of human pluripotent stem cells-derived brain organoids to model cerebellar diseases by João Brás, Daniel Henriques, Ricardo Moreira, Magda M. Santana, Rita Silva-Pedrosa, Diana Adão, Sandra Braz, Ana Rita Álvaro, Luís Pereira de Almeida, Liliana S. Mendonça

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Isolation of Extracellular Vesicles from Human Follicular Fluid: Size-Exclusion Chromatography versus Ultracentrifugation by Maria Soares, Maria M. Pinto, Rui Jorge Nobre, Luís Pereira de Almeida, Maria da Graça Rasteiro, Teresa Almeida-Santos, João Ramalho-Santos, Ana Paula Sousa

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Control of Huntington’s Disease-Associated Phenotypes by the Striatum-Enriched Transcription Factor Foxp2 by Lea J. Hachigian, Vitor Carmona, Robert J. Fenster, Ruth Kulicke, Adrian Heilbut, Annie Sittler, Luís Pereira de Almeida, Jill P. Mesirov, Fan Gao, Eric D. Kolaczyk, Myriam Heiman

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Moderate long-term modulation of neuropeptide Y in hypothalamic arcuate nucleus induces energy balance alterations in adult rats. by Lígia Sousa-Ferreira, Manuel Garrido, Isabel Nascimento-Ferreira, Clévio Nobrega, Ana Santos-Carvalho, Ana Rita Alvaro, Joana Rosmaninho-Salgado, Manuella Kaster, Sebastian Kügler, Luís Pereira de Almeida, Claudia Cavadas

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Generation of human iPSC line from a patient with laterality defects and associated congenital heart anomalies carrying a DAND5 missense alteration by Fernando Cristo, José M. Inácio, Graça Rosas, Isabel Marques Carreira, Joana Barbosa Melo, Luís Pereira de Almeida, Patrícia Mendes, Duarte Saraiva Martins, José Maio, Rui Anjos, José A. Belo

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Cerebellar morphometric and spectroscopic biomarkers for Machado-Joseph Disease by Catarina Oliveira Miranda, Rui Jorge Nobre, Vitor Hugo Paiva, João Valente Duarte, João Castelhano, Lorena Itatí Petrella, José Sereno, Magda Santana, Sónia Afonso, Cristina Januário, Miguel Castelo-Branco, Luís Pereira de Almeida

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Highly Specific Blood-Brain Barrier Transmigrating Single-Domain Antibodies Selected by an In Vivo Phage Display Screening by Sandra Isabel Aguiar, Joana N. R. Dias, Ana Santos André, Marta Lisete Silva, Diana Martins, Belmira Carrapiço, Miguel Castanho, João Carriço, Marco Cavaco, Maria Manuela Gaspar, Rui Jorge Nobre, Luís Pereira de Almeida, Soraia Oliveira, Lurdes Gano, João D. G. Correia, Carlos Barbas, João Gonçalves, Vera Neves, Frederico Aires-da-Silva

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Blood and cerebellar abundance of ATXN3 splice variants in spinocerebellar ataxia type 3/Machado-Joseph disease by Mafalda Raposo, Jeannette Hübener-Schmid, Rebecca Tagett, Ana F. Ferreira, Ana Rosa Vieira Melo, João Vasconcelos, Paula Pires, Teresa Kay, Hector Garcia-Moreno, Paola Giunti, Magda M. Santana, Luis Pereira de Almeida, Jon Infante, Bart P. van de Warrenburg, Jeroen J. de Vries, Jennifer Faber, Thomas Klockgether, Nicolas Casadei, Jakob Admard, Ludger Schöls, Olaf Riess, Maria do Carmo Costa, Manuela Lima

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