Impairment in inflammasome signaling by the chronic Pseudomonas aeruginosa isolates from cystic fibrosis patients results in an increase in inflammatory response by Melissa S. Phuong, Rafael E. Hernandez, Daniel J. Wolter, Lucas R. Hoffman, Subash Sad

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Most Short Children with Cystic Fibrosis Do Not Catch Up by Adulthood by Margaret P. Marks, Sonya L. Heltshe, Arthur Baines, Bonnie W. Ramsey, Lucas R. Hoffman, Michael S. Stalvey

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The end of the reign of a “master regulator’’? A defect in function of the LasR quorum sensing regulator is a common feature of Pseudomonas aeruginosa isolates by Mylène C. Trottier, Thays de Oliveira Pereira, Marie-Christine Groleau, Lucas R. Hoffman, Ajai A. Dandekar, Eric Déziel

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How low can we go? The implications of low bacterial load in respiratory microbiota studies by Robyn L. Marsh, Maria T. Nelson, Chris E. Pope, Amanda J. Leach, Lucas R. Hoffman, Anne B. Chang, Heidi C. Smith-Vaughan

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A Refined, Controlled 16S rRNA Gene Sequencing Approach Reveals Limited Detection of Cerebrospinal Fluid Microbiota in Children with Bacterial Meningitis by Christopher E. Pope, Kathryn B. Whitlock, Paul Hodor, David D. Limbrick, Patrick J. McDonald, Jason Hauptman, Lucas R. Hoffman, Tamara D. Simon

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Characterization of cerebrospinal fluid (CSF) microbiota at the time of initial surgical intervention for children with hydrocephalus by Shailly Pandey, Kathryn B. Whitlock, Matthew R. Test, Paul Hodor, Christopher E. Pope, David D. Limbrick, Patrick J. McDonald, Jason S. Hauptman, Lucas R. Hoffman, Tamara D. Simon

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<named-content content-type="genus-species">Staphylococcus aureus</named-content> Protein A Mediates Interspecies Interactions at the Cell Surface of <named-content content-type="g... by Catherine R. Armbruster, Daniel J. Wolter, Meenu Mishra, Hillary S. Hayden, Matthew C. Radey, Gennifer Merrihew, Michael J. MacCoss, Jane Burns, Daniel J. Wozniak, Matthew R. Parsek, Lucas R. Hoffman

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LasR Variant Cystic Fibrosis Isolates Reveal an Adaptable Quorum-Sensing Hierarchy in <named-content content-type="genus-species">Pseudomonas aeruginosa</named-content> by John B. Feltner, Daniel J. Wolter, Christopher E. Pope, Marie-Christine Groleau, Nicole E. Smalley, E. Peter Greenberg, Nicole Mayer-Hamblett, Jane Burns, Eric Déziel, Lucas R. Hoffman, Ajai A. Dandekar

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Nutrient availability as a mechanism for selection of antibiotic tolerant Pseudomonas aeruginosa within the CF airway. by Lucas R Hoffman, Anthony R Richardson, Laura S Houston, Hemantha D Kulasekara, Willm Martens-Habbena, Mikkel Klausen, Jane L Burns, David A Stahl, Daniel J Hassett, Ferric C Fang, Samuel I Miller

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Correction: Heterogeneity in surface sensing suggests a division of labor in Pseudomonas aeruginosa populations by Catherine R Armbruster, Calvin K Lee, Jessica Parker-Gilham, Jaime de Anda, Aiguo Xia, Kun Zhao, Keiji Murakami, Boo Shan Tseng, Lucas R Hoffman, Fan Jin, Caroline S Harwood, Gerard CL Wong, Matthew R Parsek

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Infants with cystic fibrosis have altered fecal functional capacities with potential clinical and metabolic consequences by Alexander Eng, Hillary S. Hayden, Christopher E. Pope, Mitchell J. Brittnacher, Anh T. Vo, Eli J. Weiss, Kyle R. Hager, Daniel H. Leung, Sonya L. Heltshe, Daniel Raftery, Samuel I. Miller, Lucas R. Hoffman, Elhanan Borenstein

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Heterogeneity in surface sensing suggests a division of labor in Pseudomonas aeruginosa populations by Catherine R Armbruster, Calvin K Lee, Jessica Parker-Gilham, Jaime de Anda, Aiguo Xia, Kun Zhao, Keiji Murakami, Boo Shan Tseng, Lucas R Hoffman, Fan Jin, Caroline S Harwood, Gerard CL Wong, Matthew R Parsek

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Characterization of cerebrospinal fluid (CSF) microbiota from patients with CSF shunt infection and reinfection using high throughput sequencing of 16S ribosomal RNAgenes. by Kathryn B Whitlock, Christopher E Pope, Paul Hodor, Lucas R Hoffman, David L Limbrick, Patrick J McDonald, Jason S Hauptman, Jeffrey G Ojemann, Tamara D Simon, Cerebrospinal FLuId MicroBiota in Shunts Study (CLIMB) Group

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Characterization of cerebrospinal fluid (CSF) microbiota at the time of initial surgical intervention for children with hydrocephalus. by Shailly Pandey, Kathryn B Whitlock, Matthew R Test, Paul Hodor, Christopher E Pope, David D Limbrick, Patrick J McDonald, Jason S Hauptman, Lucas R Hoffman, Tamara D Simon, Cerebrospinal FLuId MicroBiota in Shunts (CLIMB) Study Group

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Human and Extracellular DNA Depletion for Metagenomic Analysis of Complex Clinical Infection Samples Yields Optimized Viable Microbiome Profiles by Maria T. Nelson, Christopher E. Pope, Robyn L. Marsh, Daniel J. Wolter, Eli J. Weiss, Kyle R. Hager, Anh T. Vo, Mitchell J. Brittnacher, Matthew C. Radey, Hillary S. Hayden, Alexander Eng, Samuel I. Miller, Elhanan Borenstein, Lucas R. Hoffman

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The role of Psl in the failure to eradicate Pseudomonas aeruginosa biofilms in children with cystic fibrosis by Amanda J. Morris, Lindsay Jackson, Yvonne CW Yau, Courtney Reichhardt, Trevor Beaudoin, Stephanie Uwumarenogie, Kevin M. Guttman, P. Lynne Howell, Matthew R. Parsek, Lucas R. Hoffman, Dao Nguyen, Antonio DiGiandomenico, David S. Guttman, Daniel J. Wozniak, Valerie J. Waters

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Elevated exopolysaccharide levels in Pseudomonas aeruginosa flagellar mutants have implications for biofilm growth and chronic infections. by Joe J Harrison, Henrik Almblad, Yasuhiko Irie, Daniel J Wolter, Heather C Eggleston, Trevor E Randall, Jacob O Kitzman, Bethany Stackhouse, Julia C Emerson, Sharon Mcnamara, Tyler J Larsen, Jay Shendure, Lucas R Hoffman, Daniel J Wozniak, Matthew R Parsek

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CFTR dysregulation drives active selection of the gut microbiome. by Stacey M Meeker, Kevin S Mears, Naseer Sangwan, Mitchell J Brittnacher, Eli J Weiss, Piper M Treuting, Nicholas Tolley, Christopher E Pope, Kyle R Hager, Anh T Vo, Jisun Paik, Charles W Frevert, Hillary S Hayden, Lucas R Hoffman, Samuel I Miller, Adeline M Hajjar

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Pharmacologic improvement of CFTR function rapidly decreases sputum pathogen density, but lung infections generally persist by David P. Nichols, Sarah J. Morgan, Michelle Skalland, Anh T. Vo, Jill M. Van Dalfsen, Sachinkumar B.P. Singh, Wendy Ni, Lucas R. Hoffman, Kailee McGeer, Sonya L. Heltshe, John P. Clancy, Steven M. Rowe, Peter Jorth, Pradeep K. Singh, the PROMISE-Micro Study Group

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Pseudomonas aeruginosa aggregation and Psl expression in sputum is associated with antibiotic eradication failure in children with cystic fibrosis by Amanda J. Morris, Yvonne C. W. Yau, Subin Park, Shafinaz Eisha, Nancy McDonald, Matthew R. Parsek, P. Lynne Howell, Lucas R. Hoffman, Dao Nguyen, Antonio DiGiandomenico, Ashley M. Rooney, Bryan Coburn, Lucia Grana-Miraglia, Pauline Wang, David S. Guttman, Daniel J. Wozniak, Valerie J. Waters

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