Challenges and Opportunities for Immunoprofiling Using a Spatial High-Plex Technology: The NanoString GeoMx® Digital Spatial Profiler by Sharia Hernandez, Rossana Lazcano, Alejandra Serrano, Steven Powell, Larissa Kostousov, Jay Mehta, Khaja Khan, Wei Lu, Luisa M. Solis

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Spatial molecular and cellular determinants of STAT3 activation in liver fibrosis progression in non-alcoholic fatty liver disease by Jingjing Jiao, Jessica I. Sanchez, Omar A. Saldarriaga, Luisa M. Solis, David J. Tweardy, Dipen M. Maru, Heather L. Stevenson, Laura Beretta

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Cellular and Molecular Mechanisms of Liver Fibrosis in Patients with NAFLD by Jessica I. Sanchez, Edwin R. Parra, Jingjing Jiao, Luisa M. Solis Soto, Debora A. Ledesma, Omar A. Saldarriaga, Heather L. Stevenson, Laura Beretta

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BCL-W expression associates with poor outcome in patients with peripheral T-cell lymphoma not otherwise specified by Mario L. Marques-Piubelli, Luisa M. Solis, Edwin R. Parra, Luis Malpica Castillo, Sushanth Gouni, Ranjit Nair, Dai Chihara, Marina Konopleva, Ignacio I. Wistuba, Swaminathan P. Iyer, Francisco Vega, Paolo Strati

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The relative expression of Mig6 and EGFR is associated with resistance to EGFR kinase inhibitors. by Xiaofei Chang, Eugene Izumchenko, Luisa M Solis, Myoung Sook Kim, Aditi Chatterjee, Shizhang Ling, Constance L Monitto, Paul M Harari, Manuel Hidalgo, Steve N Goodman, Ignacio I Wistuba, Atul Bedi, David Sidransky

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Naproxen chemoprevention induces proliferation of cytotoxic lymphocytes in Lynch Syndrome colorectal mucosa by Charles M. Bowen, Nan Deng, Laura Reyes-Uribe, Edwin Roger Parra, Pedro Rocha, Luisa M. Solis, Ignacio I. Wistuba, Valerie O. Sepeda, Lana Vornik, Marjorie Perloff, Eva Szabo, Asad Umar, Krishna M. Sinha, Powel H. Brown, Eduardo Vilar, Eduardo Vilar

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Sex determining region Y-Box 2 (SOX2) is a potential cell-lineage gene highly expressed in the pathogenesis of squamous cell carcinomas of the lung. by Ping Yuan, Humam Kadara, Carmen Behrens, Ximing Tang, Denise Woods, Luisa M Solis, Jiaoti Huang, Monica Spinola, Wenli Dong, Guosheng Yin, Junya Fujimoto, Edward Kim, Yang Xie, Luc Girard, Cesar Moran, Waun Ki Hong, John D Minna, Ignacio I Wistuba

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Multidimensional single-cell analysis identifies a role for CD2-CD58 interactions in clinical antitumor T cell responses by Gabrielle Romain, Paolo Strati, Ali Rezvan, Mohsen Fathi, Irfan N. Bandey, Jay R T. Adolacion, Darren Heeke, Ivan Liadi, Mario L. Marques-Piubelli, Luisa M. Solis, Ankit Mahendra, Francisco Vega, Laurence J.N. Cooper, Harjeet Singh, Mike Mattie, Adrian Bot, Sattva S. Neelapu, Navin Varadarajan

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PD-L1+ macrophages are associated with favorable features in primary mediastinal (thymic) large B-cell lymphoma by Raphael E. Steiner, Edwin R. Parra, Francisco Vega, Lei Feng, Jason R. Westin, Sattva S. Neelapu, Paolo Strati, Michael R. Green, Christopher R. Flowers, Luisa M. Solis, Ignacio I. Wistuba, Sairah Ahmed, Ranjit Nair, Fredrick B. Hagemeister, Mansoor Noorani, Mario L. Marques-Piubelli

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Automated Cellular-Level Dual Global Fusion of Whole-Slide Imaging for Lung Adenocarcinoma Prognosis by Songhui Diao, Pingjun Chen, Eman Showkatian, Rukhmini Bandyopadhyay, Frank R. Rojas, Bo Zhu, Lingzhi Hong, Muhammad Aminu, Maliazurina B. Saad, Morteza Salehjahromi, Amgad Muneer, Sheeba J. Sujit, Carmen Behrens, Don L. Gibbons, John V. Heymach, Neda Kalhor, Ignacio I. Wistuba, Luisa M. Solis Soto, Jianjun Zhang, Wenjian Qin, Jia Wu

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Divergent genomic and epigenomic landscapes of lung cancer subtypes underscore the selection of different oncogenic pathways during tumor development. by William W Lockwood, Ian M Wilson, Bradley P Coe, Raj Chari, Larissa A Pikor, Kelsie L Thu, Luisa M Solis, Maria I Nunez, Carmen Behrens, John Yee, John English, Nevin Murray, Ming-Sound Tsao, John D Minna, Adi F Gazdar, Ignacio I Wistuba, Calum E MacAulay, Stephen Lam, Wan L Lam

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Author Correction: Targeting de novo lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer by Caterina Bartolacci, Cristina Andreani, Gonçalo Vale, Stefano Berto, Margherita Melegari, Anna Colleen Crouch, Dodge L. Baluya, George Kemble, Kurt Hodges, Jacqueline Starrett, Katerina Politi, Sandra L. Starnes, Daniele Lorenzini, Maria Gabriela Raso, Luisa M. Solis Soto, Carmen Behrens, Humam Kadara, Boning Gao, Ignacio I. Wistuba, John D. Minna, Jeffrey G. McDonald, Pier Paolo Scaglioni

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Targeting immunosuppressive Ly6C+ classical monocytes reverses anti-PD-1/CTLA-4 immunotherapy resistance by B. Leticia Rodriguez, Limo Chen, Yanli Li, Yanli Li, Shucheng Miao, Shucheng Miao, David H. Peng, Jared J. Fradette, Lixia Diao, Jessica M. Konen, Frank R. Rojas Alvarez, Luisa M. Solis, Xiaohui Yi, Xiaohui Yi, Aparna Padhye, Aparna Padhye, Laura A. Gibson, Joshua K. Ochieng, Xiaofei Zhou, Jing Wang, Don L. Gibbons, Don L. Gibbons

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Targeting de novo lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer by Caterina Bartolacci, Cristina Andreani, Gonçalo Vale, Stefano Berto, Margherita Melegari, Anna Colleen Crouch, Dodge L. Baluya, George Kemble, Kurt Hodges, Jacqueline Starrett, Katerina Politi, Sandra L. Starnes, Daniele Lorenzini, Maria Gabriela Raso, Luisa M. Solis Soto, Carmen Behrens, Humam Kadara, Boning Gao, Ignacio I. Wistuba, John D. Minna, Jeffrey G. McDonald, Pier Paolo Scaglioni

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Phase 1 Clinical Trial Evaluating the Safety and Anti-Tumor Activity of ADP-A2M10 SPEAR T-Cells in Patients With MAGE-A10+ Head and Neck, Melanoma, or Urothelial Tumors by David S. Hong, Marcus O. Butler, Russell K. Pachynski, Ryan Sullivan, Partow Kebriaei, Sarah Boross-Harmer, Armin Ghobadi, Matthew J. Frigault, Ecaterina E. Dumbrava, Amy Sauer, Francine Brophy, Jean-Marc Navenot, Svetlana Fayngerts, Zohar Wolchinsky, Robyn Broad, Dzmitry G. Batrakou, Ruoxi Wang, Luisa M. Solis, Dzifa Yawa Duose, Joseph P. Sanderson, Andrew B. Gerry, Diane Marks, Jane Bai, Elliot Norry, Paula M. Fracasso

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Single-Cell Expression Landscape of SARS-CoV-2 Receptor <i>ACE2</i> and Host Proteases in Normal and Malignant Lung Tissues from Pulmonary Adenocarcinoma Patients by Guangchun Han, Ansam Sinjab, Kieko Hara, Warapen Treekitkarnmongkol, Patrick Brennan, Kyle Chang, Elena Bogatenkova, Beatriz Sanchez-Espiridion, Carmen Behrens, Luisa M. Solis, Boning Gao, Luc Girard, Jianjun Zhang, Boris Sepesi, Tina Cascone, Lauren A. Byers, Don L. Gibbons, Jichao Chen, Seyed Javad Moghaddam, Edwin J. Ostrin, Paul Scheet, Junya Fujimoto, Jerry Shay, John V. Heymach, John D. Minna, Steven Dubinett, Ignacio I. Wistuba, Christopher S. Stevenson, Avrum E. Spira, Linghua Wang, Humam Kadara

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Single cell T cell landscape and T cell receptor repertoire profiling of AML in context of PD-1 blockade therapy by Hussein A. Abbas, Dapeng Hao, Katarzyna Tomczak, Praveen Barrodia, Jin Seon Im, Patrick K. Reville, Zoe Alaniz, Wei Wang, Ruiping Wang, Feng Wang, Gheath Al-Atrash, Koichi Takahashi, Jing Ning, Maomao Ding, Hannah C. Beird, Jairo T. Mathews, Latasha Little, Jianhua Zhang, Sreyashi Basu, Marina Konopleva, Mario L. Marques-Piubelli, Luisa M. Solis, Edwin Roger Parra, Wei Lu, Auriole Tamegnon, Guillermo Garcia-Manero, Michael R. Green, Padmanee Sharma, James P. Allison, Steven M. Kornblau, Kunal Rai, Linghua Wang, Naval Daver, Andrew Futreal

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Contextual cues from cancer cells govern cancer-associated fibroblast heterogeneity by Neus Bota-Rabassedas, Priyam Banerjee, Yichi Niu, Wenjian Cao, Jiayi Luo, Yuanxin Xi, Xiaochao Tan, Kuanwei Sheng, Young-Ho Ahn, Sieun Lee, Edwin Roger Parra, Jaime Rodriguez-Canales, Jacob Albritton, Michael Weiger, Xin Liu, Hou-Fu Guo, Jiang Yu, B. Leticia Rodriguez, Joshua J.A. Firestone, Barbara Mino, Chad J. Creighton, Luisa M. Solis, Pamela Villalobos, Maria Gabriela Raso, Daniel W. Sazer, Don L. Gibbons, William K. Russell, Gregory D. Longmore, Ignacio I. Wistuba, Jing Wang, Harold A. Chapman, Jordan S. Miller, Chenghang Zong, Jonathan M. Kurie

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Brief Report: Comprehensive Clinicogenomic Profiling of Small Cell Transformation From EGFR-Mutant NSCLC Informs Potential Therapeutic Targets by Bingnan Zhang, MD, MBA, Whitney Lewis, PharmD, C. Allison Stewart, PhD, Benjamin B. Morris, PhD, Luisa M. Solis, MD, Alejandra Serrano, MD, Yuanxin Xi, PhD, Qi Wang, PhD, Elyse R. Lopez, MD, Kyle Concannon, MD, Simon Heeke, PhD, Ximing Tang, MD, PhD, Gabriela Raso, MD, Robert J. Cardnell, PhD, Natalie Vokes, MD, George Blumenschein, MD, Yasir Elamin, MD, Frank Fosella, MD, Anne Tsao, MD, Ferdinandos Skoulidis, MD, PhD, Celyne Bueno Hume, MD, Koji Sasak, MD, PhD, Jeff Lewis, BS, Waree Rinsurongkawong, PhD, Vadeerat Rinsurongkawong, PhD, Jack Lee, PhD, Hai Tran, PhD, Jianjun Zhang, MD, PhD, Don Gibbons, MD, PhD, Ara Vaporciyan, MD, Jing Wang, PhD, Keunchil Park, MD, PhD, John V. Heymach, MD, PhD, Lauren A. Byers, MD, Carl M. Gay, MD, PhD, Xiuning Le, MD, PhD

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