Emerging Evidence for MicroRNAs as Regulators of Cancer Stem Cells by Lynette M. Sholl, Aisha Sethi

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Superior Vena Cava Syndrome associated with recurrent uterine adenosarcoma by Mackenzie W. Sullivan, Allison Gockley, Ying-Chun Lo, Lynette M. Sholl, Suzanne George, Colleen Feltmate

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Detection of EGFR mutations in non-small cell lung cancer by droplet digital PCR by Drew F. K. Williamson, Sean R. N. Marris, Vanesa Rojas-Rudilla, Jacqueline L. Bruce, Cloud P. Paweletz, Geoffrey R. Oxnard, Lynette M. Sholl, Fei Dong

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Clear cell ovarian cancers with microsatellite instability: A unique subset of ovarian cancers with increased tumor-infiltrating lymphocytes and PD-1/PD-L1 expression by Brooke E. Howitt, Kyle C. Strickland, Lynette M. Sholl, Scott Rodig, Lauren L. Ritterhouse, Dipanjan Chowdhury, Alan D. D'Andrea, Ursula A. Matulonis, Panagiotis A. Konstantinopoulos

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Case Report: Complete pathologic response to neoadjuvant selpercatinib in a patient with resectable early-stage RET fusion-positive non-small cell lung cancer by Jonathan W. Goldman, Lynette M. Sholl, Sanja Dacic, Michael C. Fishbein, Yonina R. Murciano-Goroff, Ravi Rajaram, Sylwia Szymczak, Anna M. Szpurka, Bo H. Chao, Alexander Drilon, Alexander Drilon

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Variation in targetable genomic alterations in non-small cell lung cancer by genetic ancestry, sex, smoking history, and histology by Elio Adib, Amin H. Nassar, Sarah Abou Alaiwi, Stefan Groha, Elie W. Akl, Lynette M. Sholl, Kesi S. Michael, Mark M. Awad, Pasi A. Jӓnne, Alexander Gusev, David J. Kwiatkowski

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IER5, a DNA damage response gene, is required for Notch-mediated induction of squamous cell differentiation by Li Pan, Madeleine E Lemieux, Tom Thomas, Julia M Rogers, Colin H Lipper, Winston Lee, Carl Johnson, Lynette M Sholl, Andrew P South, Jarrod A Marto, Guillaume O Adelmant, Stephen C Blacklow, Jon C Aster

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Characterization of genetics in patients with mucosal melanoma treated with immune checkpoint blockade by Elizabeth I. Buchbinder, Jason L. Weirather, Michael Manos, Brian J. Quattrochi, Lynette M. Sholl, Ryan C. Brennick, Peter Bowling, Nancy Bailey, Lisa Magarace, Patrick A. Ott, Rizwan Haq, Benjamin Izar, Anita Giobbie‐Hurder, F. Stephen Hodi

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An integrated somatic and germline approach to aid interpretation of germline variants of uncertain significance in cancer susceptibility genes by Alison Schwartz, Danielle K. Manning, Diane R. Koeller, Anu Chittenden, Raymond A. Isidro, Raymond A. Isidro, Connor P. Hayes, Feruza Abraamyan, Feruza Abraamyan, Monica Devi Manam, Meaghan Dwan, Justine A. Barletta, Justine A. Barletta, Lynette M. Sholl, Lynette M. Sholl, Matthew B. Yurgelun, Matthew B. Yurgelun, Matthew B. Yurgelun, Huma Q. Rana, Huma Q. Rana, Huma Q. Rana, Judy E. Garber, Judy E. Garber, Judy E. Garber, Arezou A. Ghazani, Arezou A. Ghazani, Arezou A. Ghazani

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Development and evaluation of INT2GRATE: a platform for comprehensive assessment of the role of germline variants informed by tumor signature profile in Lynch syndrome by Raymond A. Isidro, Raymond A. Isidro, Anu Chittenden, McKenzie Walker, Alison Schwartz, Diane R. Koeller, Connor P. Hayes, Busra Unal, Monica Devi Manam, Ryan M. Buehler, Danielle K. Manning, Lynette M. Sholl, Lynette M. Sholl, Mark S. Redston, Mark S. Redston, Matthew B. Yurgelun, Matthew B. Yurgelun, Matthew B. Yurgelun, Huma Q. Rana, Huma Q. Rana, Huma Q. Rana, Judy E. Garber, Judy E. Garber, Judy E. Garber, Arezou A. Ghazani, Arezou A. Ghazani, Arezou A. Ghazani, Arezou A. Ghazani

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192 Clinicopathologic, genomic and immunophenotypic features and outcomes to immune checkpoint inhibitors in patients with mucinous lung adenocarcinoma by Mizuki Nishino, Biagio Ricciuti, Scott J Rodig, Joao V Alessi, Jia Luo, Mark M Awad, Bruce E Johnson, Federica Pecci, Alessandro Di Federico, Malini M Gandhi, Lynette M Sholl, Maisam Makarem, Emma Voligny, Tom Nguyen, Danielle Haradon

Genomic and pathological heterogeneity in clinically diagnosed small cell lung cancer in never/light smokers identifies therapeutically targetable alterations by Atsuko Ogino, Jihyun Choi, Mika Lin, Margaret K. Wilkens, Antonio Calles, Man Xu, Anika E. Adeni, Emily S. Chambers, Marzia Capelletti, Mohit Butaney, Nathanael S. Gray, Prafulla C. Gokhale, Sangeetha Palakurthi, Paul Kirschmeier, Geoffrey R. Oxnard, Lynette M. Sholl, Pasi A. Jänne

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1511 Pan-tumor harmonization of pathologic response assessment for standardized data collection in neoadjuvant IO trials (PATHdata): Interim analysis of a multi-institutional repro... by Xiaowei Xu, Hao Wang, Michael Tetzlaff, James Ziai, Sabina Signoretti, Ashley Cimino-Mathews, Tricia Cottrell, Janis M Taube, Annikka Weissferdt, Richard A Scolyer, Pierre-Olivier Fiset, Jaime Rodriguez-Canales, Lynette M Sholl, Julie S Deutsch, Krista Chen, Carlos E de Andrea, Christine Orr, Salgado Roberto, Christian Schurch, Raja Seethala, Alexander S Baras

Genomic and biological study of fusion genes as resistance mechanisms to EGFR inhibitors by Yoshihisa Kobayashi, Geoffrey R. Oxnard, Elizabeth F. Cohen, Navin R. Mahadevan, Joao V. Alessi, Yin P. Hung, Arrien A. Bertram, David E. Heppner, Mauricio F. Ribeiro, Karina P. Sacardo, Rodrigo Saddi, Mariana P. Macedo, Rafael B. Blasco, Jiaqi Li, Kari J. Kurppa, Tom Nguyen, Emma Voligny, Guruprasad Ananda, Roberto Chiarle, Artur Katz, Michael Y. Tolstorukov, Lynette M. Sholl, Pasi A. Jänne

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mTORC1 is a mechanosensor that regulates surfactant function and lung compliance during ventilator-induced lung injury by Hyunwook Lee, Qinqin Fei, Adam Streicher, Wenjuan Zhang, Colleen Isabelle, Pragi Patel, Hilaire C. Lam, Antonio Arciniegas-Rubio, Miguel Pinilla-Vera, Diana P. Amador-Munoz, Diana Barragan-Bradford, Angelica Higuera-Moreno, Rachel K. Putman, Lynette M. Sholl, Elizabeth P. Henske, Christopher M. Bobba, Natalia Higuita-Castro, Emily M. Shalosky, R. Duncan Hite, John W. Christman, Samir N. Ghadiali, Rebecca M. Baron, Joshua A. Englert

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Plasma extracellular vesicle proteins as promising noninvasive biomarkers for diagnosis of idiopathic pulmonary fibrosis by Raju S. R. Adduri, Kai Cai, Karen Velasco‐Alzate, Ravikiran Vasireddy, Jeffrey W. Miller, Sergio Poli deFrías, Fernando Poli deFrías, Yasushi Horimasu, Hiroshi Iwamoto, Noboru Hattori, Yingze Zhang, Kevin F. Gibson, Anoop K. Pal, Zhe Chen, Daniela Nicastro, Li Li, Sujith Cherian, Lynette M. Sholl, Sreerama Shetty, Harrison Ndetan, Anthony H. Maeda, Maria A. Planchart Ferretto, Gary M. Hunninghake, David A. Schwartz, Daniel J. Kass, Ivan O. Rosas, Nagarjun V. Konduru

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Association Between Immune-Related Adverse Events and Clinical Outcomes to Programmed Cell Death Protein 1/Programmed Death-Ligand 1 Blockade in SCLC by Biagio Ricciuti, MD, Abdul Rafeh Naqash, MD, Jarushka Naidoo, MD, Kartik Sehgal, MD, Adam Miller, MD, Kenneth Kehl, MD, MPH, Deepti Venkatraman, MPH, Jacob Sands, MD, Giuseppe Lamberti, MD, Gonzalo Recondo, MD, PhD, Jiajia Zhang, MD, Shravanti Macherla, MD, Sameer Baig, MD, Paul Walker, MD, Deepa Rangachari, MD, Justin F. Gainor, MD, Daniel B. Costa, MD, Naiyer Rizvi, MD, Lynette M. Sholl, MD, Mizuki Nishino, MD, MPH, Brian Henick, MD, Anna F. Farago, MD, PhD, Mark M. Awad, MD, PhD

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Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2 by Haikuo Zhang, Christine Fillmore Brainson, Shohei Koyama, Amanda J. Redig, Ting Chen, Shuai Li, Manav Gupta, Carolina Garcia-de-Alba, Margherita Paschini, Grit S. Herter-Sprie, Gang Lu, Xin Zhang, Bryan P. Marsh, Stephanie J. Tuminello, Chunxiao Xu, Zhao Chen, Xiaoen Wang, Esra A. Akbay, Mei Zheng, Sangeetha Palakurthi, Lynette M. Sholl, Anil K. Rustgi, David J. Kwiatkowski, J Alan Diehl, Adam J. Bass, Norman E. Sharpless, Glenn Dranoff, Peter S. Hammerman, Hongbin Ji, Nabeel Bardeesy, Dieter Saur, Hideo Watanabe, Carla F. Kim, Kwok-Kin Wong

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Erratum: Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2 by Haikuo Zhang, Christine Fillmore Brainson, Shohei Koyama, Amanda J. Redig, Ting Chen, Shuai Li, Manav Gupta, Carolina Garcia-de-Alba, Margherita Paschini, Grit S. Herter-Sprie, Gang Lu, Xin Zhang, Bryan P Marsh, Stephanie J. Tuminello, Chunxiao Xu, Zhao Chen, Xiaoen Wang, Esra A. Akbay, Mei Zheng, Sangeetha Palakurthi, Lynette M. Sholl, Anil K. Rustgi, David J. Kwiatkowski, J. Alan Diehl, Adam J. Bass, Norman E. Sharpless, Glenn Dranoff, Peter S. Hammerman, Hongbin Ji, Nabeel Bardeesy, Dieter Saur, Hideo Watanabe, Carla F. Kim, Kwok-Kin Wong

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218 Prospective spatial immune cell profiling identifies features of the tumor-immune microenvironment associated with genomic alterations and patient survival in a 2,023 patient p... by Sara M Tolaney, James Lindsay, Michael Manos, Biagio Ricciuti, Anita Giobbie-Hurder, Scott J Rodig, Joao V Alessi, Mark M Awad, Sandro Santagata, Bruce E Johnson, Glenn J Hanna, Elio Adib, Jason Weirather, Xinan Wang, Bijaya Sharma, Kathleen Pfaff, Kristen D Felt, William Lotter, Panagiotis Konstantinopoulos, Madison Turner, Federica Pecci, Emma L Welsh, Stephanie M Jones, Jennifer O Altreuter, Ian D Dryg, Alessandro Di Federico, Malini M Gandhi, Sabrina J Chan, Marta Holovatska, Melissa E Hughes, O’Meara Tess A, Neal I Lindeman, Jennifer Curtis, Peter K Sorger, Ethan Cerami, Lynette M Sholl, Jonathan A Novak