Targeting protein-protein interactions: suppression of Stat3 dimerization with rationally designed small-molecule, nonpeptidic SH2 domain binders. по Gunning, P, Glenn, M, Siddiquee, K, Katt, W, Masson, E, Sebti, S, Turkson, J, Hamilton, A

A Phase I, open-label study with escalating doses of intravenous PTK787/ZK 222584, a multi-VEGF receptor inhibitor, followed by multiple oral daily dosing to assess the absolute bi... по Pavel, M, Schuppan, D, Jost, L, Kerr, D, Harris, A, Jalava, T, Masson, E, Palacay-Radona, M, Koehne, C