The X-Linked Inhibitor of Apoptosis Protein Inhibitor Embelin Suppresses Inflammation and Bone Erosion in Collagen Antibody Induced Arthritis Mice nork Anak A. S. S. K. Dharmapatni, Melissa D. Cantley, Victor Marino, Egon Perilli, Tania N. Crotti, Malcolm D. Smith, David R. Haynes

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Triple DMARD treatment in early rheumatoid arthritis modulates synovial T cell activation and plasmablast/plasma cell differentiation pathways. nork Alice M Walsh, Mihir D Wechalekar, Yanxia Guo, Xuefeng Yin, Helen Weedon, Susanna M Proudman, Malcolm D Smith, Sunil Nagpal

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Transcriptomic profiling of programmed cell death 1 (PD-1) expressing T cells in early rheumatoid arthritis identifies a decreased CD4 + PD-1 + signature post-treatment nork Katie Lowe, Annabelle Small, Qingxuan Song, Ling-Yang Hao, William Murray-Brown, Susanna Proudman, Malcolm D. Smith, Sunil Nagpal, Mihir D. Wechalekar

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Nivolumab-induced synovitis is characterized by florid T cell infiltration and rapid resolution with synovial biopsy-guided therapy nork Susanna Proudman, Sonja Klebe, William Murray-Brown, Tom D Wilsdon, Helen Weedon, Shawgi Sukumaran, Jennifer G Walker, Malcolm D Smith, Mihir D Wechalekar

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Differential expansion of T peripheral helper cells in early rheumatoid arthritis and osteoarthritis synovium nork Susanna M Proudman, Ling-Yang Hao, William Murray-Brown, Helen Weedon, Malcolm D Smith, Mihir D Wechalekar, Susan E Lester, Sunil Nagpal, Yanxia Guo, Annabelle Small, Katie Lowe, Navin L Rao

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Integrative analysis reveals CD38 as a therapeutic target for plasma cell-rich pre-disease and established rheumatoid arthritis and systemic lupus erythematosus nork Suzanne Cole, Alice Walsh, Xuefeng Yin, Mihir D. Wechalekar, Malcolm D. Smith, Susanna M. Proudman, Douglas J. Veale, Ursula Fearon, Costantino Pitzalis, Frances Humby, Michele Bombardieri, Amy Axel, Homer Adams, Christopher Chiu, Michael Sharp, John Alvarez, Ian Anderson, Loui Madakamutil, Sunil Nagpal, Yanxia Guo

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Immune checkpoint inhibitor PD-1 pathway is down-regulated in synovium at various stages of rheumatoid arthritis disease progression. nork Yanxia Guo, Alice M Walsh, Mary Canavan, Mihir D Wechalekar, Suzanne Cole, Xuefeng Yin, Brittney Scott, Mathew Loza, Carl Orr, Trudy McGarry, Michele Bombardieri, Frances Humby, Susanna M Proudman, Costantino Pitzalis, Malcolm D Smith, Joshua R Friedman, Ian Anderson, Loui Madakamutil, Douglas J Veale, Ursula Fearon, Sunil Nagpal

Testu osoa