Machine learning framework to extract the biomarker potential of plasma IgG N-glycans towards disease risk stratification by Konstantinos Flevaris, Joseph Davies, Shoh Nakai, Frano Vučković, Gordan Lauc, Malcolm G. Dunlop, Cleo Kontoravdi

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A novel test for gene-ancestry interactions in genome-wide association data. by Joanna L Davies, Jean-Baptiste Cazier, Malcolm G Dunlop, Richard S Houlston, Ian P Tomlinson, Chris C Holmes

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Farming, Foreign Holidays, and Vitamin D in Orkney. by Emily Weiss, Lina Zgaga, Stephanie Read, Sarah Wild, Malcolm G Dunlop, Harry Campbell, Ruth McQuillan, James F Wilson

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Instrumental variable estimation of the causal effect of plasma 25-hydroxy-vitamin D on colorectal cancer risk: a mendelian randomization analysis. by Evropi Theodoratou, Tom Palmer, Lina Zgaga, Susan M Farrington, Paul McKeigue, Farhat V N Din, Albert Tenesa, George Davey-Smith, Malcolm G Dunlop, Harry Campbell

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The association of dietary intake of purine-rich vegetables, sugar-sweetened beverages and dairy with plasma urate, in a cross-sectional study. by Lina Zgaga, Evropi Theodoratou, Janet Kyle, Susan M Farrington, Felix Agakov, Albert Tenesa, Marion Walker, Geraldine McNeill, Alan F Wright, Igor Rudan, Malcolm G Dunlop, Harry Campbell

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Transcriptional dynamics of colorectal cancer risk associated variation at 11q23.1 correlate with tuft cell abundance and marker expression in silico by Bradley T. Harris, Vidya Rajasekaran, James P. Blackmur, Alan O’Callaghan, Kevin Donnelly, Maria Timofeeva, Peter G. Vaughan-Shaw, Farhat V. N. Din, Malcolm G. Dunlop, Susan M. Farrington

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Gene Co-Expression Network Analysis Identifies Vitamin D-Associated Gene Modules in Adult Normal Rectal Epithelium Following Supplementation by James P. Blackmur, James P. Blackmur, Peter G. Vaughan-Shaw, Peter G. Vaughan-Shaw, Kevin Donnelly, Kevin Donnelly, Bradley T. Harris, Victoria Svinti, Anna-Maria Ochocka-Fox, Paz Freile, Marion Walker, Marion Walker, Toby Gurran, Toby Gurran, Stuart Reid, Stuart Reid, Colin A. Semple, Farhat V. N. Din, Maria Timofeeva, Maria Timofeeva, Malcolm G. Dunlop, Malcolm G. Dunlop, Susan M. Farrington

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SMAD7 variant rs4939827 is associated with colorectal cancer risk in Croatian population. by Iva Kirac, Petar Matošević, Goran Augustin, Iva Šimunović, Vedran Hostić, Sven Župančić, Caroline Hayward, Natasa Antoljak, Igor Rudan, Harry Campbell, Malcolm G Dunlop, Danko Velimir Vrdoljak, Dujo Kovačević, Lina Zgaga

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Impact of ambient air pollution on colorectal cancer risk and survival: insights from a prospective cohort and epigenetic Mendelian randomization studyResearch in context by Fangyuan Jiang, Jianhui Zhao, Jing Sun, Wenxi Chen, Yuyuan Zhao, Siyun Zhou, Shuai Yuan, Maria Timofeeva, Philip J. Law, Susanna C. Larsson, Dong Chen, Richard S. Houlston, Malcolm G. Dunlop, Evropi Theodoratou, Xue Li

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Identification of novel protein biomarkers and drug targets for colorectal cancer by integrating human plasma proteome with genome by Jing Sun, Jianhui Zhao, Fangyuan Jiang, Lijuan Wang, Qian Xiao, Fengyan Han, Jie Chen, Shuai Yuan, Jingsun Wei, Susanna C. Larsson, Honghe Zhang, Malcolm G Dunlop, Susan M Farrington, Kefeng Ding, Evropi Theodoratou, Xue Li

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N6-methyladenosine related gene expression signatures for predicting the overall survival and immune responses of patients with colorectal cancer by Lili Yu, Lili Yu, Lijuan Wang, Jing Sun, Xuan Zhou, Yeting Hu, Lidan Hu, Yazhou He, Chunqing Lin, Jie Chen, Xiaolin Xu, Malcolm G. Dunlop, Evropi Theodoratou, Evropi Theodoratou, Kefeng Ding, Kefeng Ding, Xue Li

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Rare disruptive mutations and their contribution to the heritable risk of colorectal cancer by Daniel Chubb, Peter Broderick, Sara E. Dobbins, Matthew Frampton, Ben Kinnersley, Steven Penegar, Amy Price, Yussanne P. Ma, Amy L. Sherborne, Claire Palles, Maria N. Timofeeva, D. Timothy Bishop, Malcolm G. Dunlop, Ian Tomlinson, Richard S. Houlston

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Altered DNA methylation within DNMT3A, AHRR, LTA/TNF loci mediates the effect of smoking on inflammatory bowel disease by Han Zhang, Rahul Kalla, Jie Chen, Jianhui Zhao, Xuan Zhou, Alex Adams, Alexandra Noble, Nicholas T. Ventham, Judith Wellens, Gwo-Tzer Ho, Malcolm G. Dunlop, Jan Krzysztof Nowak, Yuan Ding, Zhanju Liu, Jack Satsangi, Evropi Theodoratou, Xue Li

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Systematic Evaluation of Normalization Methods for Glycomics Data Based on Performance of Network Inference by Elisa Benedetti, Nathalie Gerstner, Maja Pučić-Baković, Toma Keser, Karli R. Reiding, L. Renee Ruhaak, Tamara Štambuk, Maurice H.J. Selman, Igor Rudan, Ozren Polašek, Caroline Hayward, Marian Beekman, Eline Slagboom, Manfred Wuhrer, Malcolm G. Dunlop, Gordan Lauc, Jan Krumsiek

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RNA splicing is a key mediator of tumour cell plasticity and a therapeutic vulnerability in colorectal cancer by Adam E. Hall, Sebastian Öther-Gee Pohl, Patrizia Cammareri, Stuart Aitken, Nicholas T. Younger, Michela Raponi, Caroline V. Billard, Alfonso Bolado Carrancio, Aslihan Bastem, Paz Freile, Fiona Haward, Ian R. Adams, Javier F. Caceres, Paula Preyzner, Alex von Kriegsheim, Malcolm G. Dunlop, Farhat V. Din, Kevin B. Myant

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Correction: Disease consequences of higher adiposity uncoupled from its adverse metabolic effects using Mendelian randomisation by Susan Martin, Jessica Tyrrell, E Louise Thomas, Matthew J Bown, Andrew R Wood, Robin N Beaumont, Lam C Tsoi, Philip E Stuart, James T Elder, Philip Law, Richard Houlston, Christopher Kabrhel, Nikos Papadimitriou, Marc Gunter, Caroline Bull, Joshua A Bell, Emma E Vincent, Naveed Sattar, Malcolm G Dunlop, Ian PM Tomlinson, Sara Lindström, INVENT consortium, Jimmy D Bell, Timothy Frayling, Hanieh Yaghootkar

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Coding variants in NOD-like receptors: An association study on risk and survival of colorectal cancer. by Stefanie Huhn, Miguel I da Silva Filho, Tharmila Sanmuganantham, Tica Pichulik, Calogerina Catalano, Barbara Pardini, Alessio Naccarati, Veronika Polakova-Vymetálkova, Katerina Jiraskova, Ludmila Vodickova, Pavel Vodicka, Markus W Löffler, Lioba Courth, Jan Wehkamp, Farhat V N Din, Maria Timofeeva, Susan M Farrington, Lina Jansen, Kari Hemminki, Jenny Chang-Claude, Hermann Brenner, Michael Hoffmeister, Malcolm G Dunlop, Alexander N R Weber, Asta Försti

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Disease consequences of higher adiposity uncoupled from its adverse metabolic effects using Mendelian randomisation by Susan Martin, Jessica Tyrrell, E Louise Thomas, Matthew J Bown, Andrew R Wood, Robin N Beaumont, Lam C Tsoi, Philip E Stuart, James T Elder, Philip Law, Richard Houlston, Christopher Kabrhel, Nikos Papadimitriou, Marc J Gunter, Caroline J Bull, Joshua A Bell, Emma E Vincent, Naveed Sattar, Malcolm G Dunlop, Ian PM Tomlinson, Sara Lindström, INVENT consortium, Jimmy D Bell, Timothy M Frayling, Hanieh Yaghootkar

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Multiple common susceptibility variants near BMP pathway loci GREM1, BMP4, and BMP2 explain part of the missing heritability of colorectal cancer. by Ian P M Tomlinson, Luis G Carvajal-Carmona, Sara E Dobbins, Albert Tenesa, Angela M Jones, Kimberley Howarth, Claire Palles, Peter Broderick, Emma E M Jaeger, Susan Farrington, Annabelle Lewis, James G D Prendergast, Alan M Pittman, Evropi Theodoratou, Bianca Olver, Marion Walker, Steven Penegar, Ella Barclay, Nicola Whiffin, Lynn Martin, Stephane Ballereau, Amy Lloyd, Maggie Gorman, Steven Lubbe, COGENT Consortium, CORGI Collaborators, EPICOLON Consortium, Bryan Howie, Jonathan Marchini, Clara Ruiz-Ponte, Ceres Fernandez-Rozadilla, Antoni Castells, Angel Carracedo, Sergi Castellvi-Bel, David Duggan, David Conti, Jean-Baptiste Cazier, Harry Campbell, Oliver Sieber, Lara Lipton, Peter Gibbs, Nicholas G Martin, Grant W Montgomery, Joanne Young, Paul N Baird, Steven Gallinger, Polly Newcomb, John Hopper, Mark A Jenkins, Lauri A Aaltonen, David J Kerr, Jeremy Cheadle, Paul Pharoah, Graham Casey, Richard S Houlston, Malcolm G Dunlop

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Association analyses identify 31 new risk loci for colorectal cancer susceptibility by Philip J. Law, Maria Timofeeva, Ceres Fernandez-Rozadilla, Peter Broderick, James Studd, Juan Fernandez-Tajes, Susan Farrington, Victoria Svinti, Claire Palles, Giulia Orlando, Amit Sud, Amy Holroyd, Steven Penegar, Evropi Theodoratou, Peter Vaughan-Shaw, Harry Campbell, Lina Zgaga, Caroline Hayward, Archie Campbell, Sarah Harris, Ian J. Deary, John Starr, Laura Gatcombe, Maria Pinna, Sarah Briggs, Lynn Martin, Emma Jaeger, Archana Sharma-Oates, James East, Simon Leedham, Roland Arnold, Elaine Johnstone, Haitao Wang, David Kerr, Rachel Kerr, Tim Maughan, Richard Kaplan, Nada Al-Tassan, Kimmo Palin, Ulrika A. Hänninen, Tatiana Cajuso, Tomas Tanskanen, Johanna Kondelin, Eevi Kaasinen, Antti-Pekka Sarin, Johan G. Eriksson, Harri Rissanen, Paul Knekt, Eero Pukkala, Pekka Jousilahti, Veikko Salomaa, Samuli Ripatti, Aarno Palotie, Laura Renkonen-Sinisalo, Anna Lepistö, Jan Böhm, Jukka-Pekka Mecklin, Daniel D. Buchanan, Aung-Ko Win, John Hopper, Mark E. Jenkins, Noralane M. Lindor, Polly A. Newcomb, Steven Gallinger, David Duggan, Graham Casey, Per Hoffmann, Markus M. Nöthen, Karl-Heinz Jöckel, Douglas F. Easton, Paul D. P. Pharoah, Julian Peto, Federico Canzian, Anthony Swerdlow, Rosalind A. Eeles, Zsofia Kote-Jarai, Kenneth Muir, Nora Pashayan, The PRACTICAL consortium, Andrea Harkin, Karen Allan, John McQueen, James Paul, Timothy Iveson, Mark Saunders, Katja Butterbach, Jenny Chang-Claude, Michael Hoffmeister, Hermann Brenner, Iva Kirac, Petar Matošević, Philipp Hofer, Stefanie Brezina, Andrea Gsur, Jeremy P. Cheadle, Lauri A. Aaltonen, Ian Tomlinson, Richard S. Houlston, Malcolm G. Dunlop

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