Synthesis and SAR studies of 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine derivatives as potent inhibitors of Bloom helicase. by Rosenthal, A, Dexheimer, T, Gileadi, O, Nguyen, G, Chu, W, Hickson, I, Jadhav, A, Simeonov, A, Maloney, D

Synthesis and SAR studies of 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine derivatives as potent inhibitors of Bloom helicase by Rosenthal, A, Dexheimer, T, Gileadi, O, Nguyen, G, Chu, W, Hickson, I, Jadhav, A, Simeonov, A, Maloney, D

High-affinity inhibitors of human NAD-dependent 15-hydroxyprostaglandin dehydrogenase: mechanisms of inhibition and structure-activity relationships. by Niesen, F, Schultz, L, Jadhav, A, Bhatia, C, Guo, K, Maloney, D, Pilka, E, Wang, M, Oppermann, U, Heightman, T, Simeonov, A

A cell-permeable ester derivative of the JmjC histone demethylase inhibitor IOX1. by Schiller, R, Scozzafava, G, Tumber, A, Wickens, JR, Bush, J, Rai, G, Lejeune, C, Choi, H, Yeh, T, Chan, M, Mott, B, McCullagh, J, Maloney, D, Schofield, C, Kawamura, A

Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors. by King, O, Li, X, Sakurai, M, Kawamura, A, Rose, N, Ng, S, Quinn, A, Rai, G, Mott, B, Beswick, P, Klose, R, Oppermann, U, Jadhav, A, Heightman, T, Maloney, D, Schofield, C, Simeonov, A

A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells. by Nguyen, G, Dexheimer, T, Rosenthal, A, Chu, W, Singh, D, Mosedale, G, Bachrati, C, Schultz, L, Sakurai, M, Savitsky, P, Abu, M, McHugh, P, Bohr, V, Harris, C, Jadhav, A, Gileadi, O, Maloney, D, Simeonov, A, Hickson, I

Discovery of orally bioavailable, quinoline-based aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with potent cellular activity by Yang, S, Martinez, N, Yasgar, A, Danchik, C, Johansson, C, Wang, Y, Baljinnyam, B, Wang, A, Xu, X, Shah, P, Cheff, D, Wang, X, Roth, J, Lal-Nag, M, Dunford, J, Oppermann, U, Vasiliou, V, Simeonov, A, Jadhav, A, Maloney, D