The fecal metabolome as a functional readout of the gut microbiome gan Zierer, J, Jackson, M, Kastenmüller, G, Mangino, M, Long, T, Telenti, A, Mohney, R, Small, K, Bell, J, Steves, C, Valdes, A, Spector, T, Menni, C

Heritable components of the human fecal microbiome are associated with visceral fat gan Beaumont, M, Goodrich, J, Jackson, M, Yet, I, Davenport, E, Vieira-Silva, S, Debelius, J, Pallister, T, Mangino, M, Raes, J, Knight, R, Clark, A, Ley, R, Spector, T, Bell, J

Glycosylation of immunoglobulin g: role of genetic and epigenetic influences gan Menni, C, Keser, T, Mangino, M, Bell, J, Erte, I, Akmačić, I, Vučković, F, Pučić Baković, M, Gornik, O, McCarthy, M, Zoldoš, V, Spector, T, Lauc, G, Valdes, A

Genetic variation in the SMAD3 gene is associated with hip and knee osteoarthritis. gan Valdes, A, Spector, T, Tamm, A, Kisand, K, Doherty, SA, Dennison, E, Mangino, M, Tamm, A, Kerna, I, Hart, D, Wheeler, M, Cooper, C, Lories, R, Arden, N, Doherty, M

Genomic inflation factors under polygenic inheritance gan Yang, J, Weedon, M, Purcell, S, Lettre, G, Estrada, K, Willer, C, Smith, A, Ingelsson, E, O'Connell, JR, Mangino, M, Mägi, R, Madden, P, Heath, A, Nyholt, DR, Martin, N, Montgomery, G, Frayling, T, Hirschhorn, J, McCarthy, M, Goddard, M, Visscher, P

A GENOME WIDE ASSOCIATION STUDY ON JOINT SPACE WIDTH IDENTIFIES A NEW GENE INVOLVED IN CARTILAGE THICKNESS AND OSTEOARTHRITIS gan Betancourt, M, Valdes, A, Cornelis, F, Kerkhof, H, Doherty, S, Wheeler, M, Zhang, W, Maciewicz, R, Muir, K, Hart, D, Metrustry, S, Mangino, M, Arden, N, Cailotto, F, Peters, M, Rivadeneira, F, Hofman, A, Uitterlinden, A, Doherty, M, Spector, T, Lories, R, van Meurs, J

Genomic inflation factors under polygenic inheritance. gan Yang, J, Weedon, M, Purcell, S, Lettre, G, Estrada, K, Willer, C, Smith, A, Ingelsson, E, O'Connell, JR, Mangino, M, Mägi, R, Madden, P, Heath, A, Nyholt, DR, Martin, N, Montgomery, G, Frayling, T, Hirschhorn, J, McCarthy, M, Goddard, M, Visscher, P

Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population. gan Bell, J, Tsai, P, Yang, T, Pidsley, R, Nisbet, J, Glass, D, Mangino, M, Zhai, G, Zhang, F, Valdes, A, Shin, S, Dempster, E, Murray, R, Grundberg, E, Hedman, A, Nica, A, Small, K, Dermitzakis, E, McCarthy, M, Mill, J, Spector, T, Deloukas, P

Genome-wide association and functional studies identify the DOT1L gene to be involved in cartilage thickness and hip osteoarthritis. gan Betancourt, C, Cailotto, F, Kerkhof, H, Cornelis, F, Doherty, SA, Hart, D, Hofman, A, Luyten, F, Maciewicz, R, Mangino, M, Metrustry, S, Muir, K, Peters, M, Rivadeneira, F, Wheeler, M, Zhang, W, Arden, N, Spector, T, Uitterlinden, A, Doherty, M, Lories, R, Valdes, A, van Meurs, J

Genome-wide association analysis identifies 20 loci that influence adult height. gan Weedon, M, Lango, H, Lindgren, C, Wallace, C, Evans, D, Mangino, M, Freathy, R, Perry, JR, Stevens, S, Hall, A, Samani, N, Shields, B, Prokopenko, I, Farrall, M, Dominiczak, A, Johnson, T, Bergmann, S, Beckmann, J, Vollenweider, P, Waterworth, D, Mooser, V, Palmer, C, Morris, A, Ouwehand, W, Zhao, J

Genetic architecture of circulating lipid levels. gan Demirkan, A, Amin, N, Isaacs, A, Jarvelin, MR, Whitfield, J, Wichmann, H, Kyvik, K, Rudan, I, Gieger, C, Hicks, A, Johansson, Å, Hottenga, J, Smith, J, Wild, S, Pedersen, N, Willemsen, G, Mangino, M, Hayward, C, Uitterlinden, A, Hofman, A, Witteman, J, Montgomery, G, Pietiläinen, K, Rantanen, T, Kaprio, J

Genetic architecture of circulating lipid levels gan Demirkan, A, Amin, N, Isaacs, A, Jarvelin, M, Whitfield, J, Wichmann, H, Kyvik, K, Rudan, I, Gieger, C, Hicks, A, Johansson, A, Hottenga, J, Smith, J, Wild, S, Pedersen, N, Willemsen, G, Mangino, M, Hayward, C, Uitterlinden, A, Hofman, A, Witteman, J, Montgomery, G, Pietiläinen, K, Rantanen, T, Kaprio, J

Large scale replication study of the association between HLA class II/BTNL2 variants and osteoarthritis of the knee in European-descent populations. gan Valdes, A, Styrkarsdottir, U, Doherty, M, Morris, D, Mangino, M, Tamm, A, Doherty, SA, Kisand, K, Kerna, I, Tamm, A, Wheeler, M, Maciewicz, R, Zhang, W, Muir, K, Dennison, E, Hart, D, Metrustry, S, Jonsdottir, I, Jonsson, G, Jonsson, H, Ingvarsson, T, Cooper, C, Vyse, T, Spector, T, Stefansson, K, Arden, N

Identification of seven loci affecting mean telomere length and their association with disease. gan Codd, V, Nelson, C, Albrecht, E, Mangino, M, Deelen, J, Buxton, J, Hottenga, J, Fischer, K, Esko, T, Surakka, I, Broer, L, Nyholt, DR, Mateo Leach, I, Salo, P, Hägg, S, Matthews, M, Palmen, J, Norata, G, O'Reilly, P, Saleheen, D, Amin, N, Balmforth, A, Beekman, M, de Boer, R, Böhringer, S

Metabolomics reveals a link between homocysteine and lipid metabolism and leukocyte telomere length: The ENGAGE consortium gan Van Der Spek, A, Broer, L, Draisma, HHM, Pool, R, Albrecht, E, Beekman, M, Mangino, M, Raag, M, Nyholt, DR, Dharuri, HK, Codd, V, Amin, N, De Geus, EJC, Deelen, J, Demirkan, A, Yet, I, Fischer, K, Haller, T, Henders, AK, Isaacs, A, Medland, SE, Montgomery, GW, Mooijaart, SP, Strauch, K, Suchiman, HED

Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study. gan Vimaleswaran, K, Cavadino, A, Berry, D, Jorde, R, Dieffenbach, A, Lu, C, Alves, A, Heerspink, H, Tikkanen, E, Eriksson, J, Wong, A, Mangino, M, Jablonski, K, Nolte, I, Houston, D, Ahluwalia, T, van der Most, P, Pasko, D, Zgaga, L, Thiering, E, Vitart, V, Fraser, R, Huffman, J, de Boer, R, Schöttker, B

Common genetic determinants of vitamin D insufficiency: a genome-wide association study. gan Wang, T, Zhang, F, Richards, J, Kestenbaum, B, van Meurs, J, Berry, D, Kiel, D, Streeten, E, Ohlsson, C, Koller, D, Peltonen, L, Cooper, J, O'Reilly, P, Houston, D, Glazer, N, Vandenput, L, Peacock, M, Shi, J, Rivadeneira, F, McCarthy, M, Anneli, P, de Boer, I, Mangino, M, Kato, B, Smyth, D

Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms. gan Zhai, G, Teumer, A, Stolk, L, Perry, JR, Vandenput, L, Coviello, A, Koster, A, Bell, J, Bhasin, S, Eriksson, J, Eriksson, A, Ernst, F, Ferrucci, L, Frayling, T, Glass, D, Grundberg, E, Haring, R, Hedman, A, Hofman, A, Kiel, D, Kroemer, H, Liu, Y, Lunetta, K, Maggio, M, Lorentzon, M, Mangino, M, Melzer, D, Miljkovic, I, Nica, A, Penninx, B, Vasan, R, Rivadeneira, F, Small, K, Soranzo, N, Uitterlinden, A, Völzke, H, Wilson, S, Xi, L, Zhuang, W, Harris, T, Murabito, J, Ohlsson, C, Murray, A, de Jong, F, Spector, T, Wallaschofski, H, Perry, J

Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations. gan Kolz, M, Johnson, T, Sanna, S, Teumer, A, Vitart, V, Perola, M, Mangino, M, Albrecht, E, Wallace, C, Farrall, M, Johansson, A, Nyholt, DR, Aulchenko, Y, Beckmann, J, Bergmann, S, Bochud, M, Brown, M, Campbell, H, Connell, J, Dominiczak, A, Homuth, G, Lamina, C, McCarthy, M, Meitinger, T, Mooser, V, Munroe, P, Nauck, M, Peden, J, Prokisch, H, Salo, P, Salomaa, V, Samani, N, Schlessinger, D, Uda, M, Volker, U, Waeber, G, Waterworth, D, Wang-Sattler, R, Wright, A, Adamski, J, Whitfield, J, Gyllensten, U, Wilson, J, Rudan, I, Pramstaller, P, Watkins, H, Doering, A, Wichmann, H, Spector, T, Peltonen, L, Volzke, H, Nagaraja, R, Vollenweider, P, Caulfield, M, Illig, T, Gieger, C

Genome-wide characterization of circulating metabolic biomarkers gan Karjalainen, MK, Karthikeyan, S, Oliver-Williams, C, Sliz, E, Allara, E, Fung, WT, Surendran, P, Zhang, W, Jousilahti, P, Kristiansson, K, Salomaa, V, Goodwin, M, Hughes, DA, Boehnke, M, Fernandes Silva, L, Yin, X, Mahajan, A, Neville, MJ, van Zuydam, NR, de Mutsert, R, Li-Gao, R, Mook-Kanamori, DO, Demirkan, A, Liu, J, Noordam, R, Trompet, S, Chen, Z, Kartsonaki, C, Li, L, Lin, K, Hagenbeek, FA, Hottenga, JJ, Pool, R, Ikram, MA, van Meurs, J, Haller, T, Milaneschi, Y, Kähönen, M, Mishra, PP, Joshi, PK, Macdonald-Dunlop, E, Mangino, M, Zierer, J, Acar, IE, Hoyng, CB, Lechanteur, YTE, Franke, L, Kurilshikov, A, Zhernakova, A, Beekman, M, Walters, RG, Karpe, F, McCarthy, MI, van Duijn, C, Kettunen, J