Manolis Kellis

Manolis Kellis at the [[American Society of Human Genetics]] (ASHG) meeting in Orlando Florida on October 19, 2017 Manolis Kellis (; born 1977) is a professor of Computer Science and Computational Biology at the Massachusetts Institute of Technology (MIT) and a member of the Broad Institute of MIT and Harvard. He is the head of the Computational Biology Group at MIT and is a Principal Investigator in the Computer Science and Artificial Intelligence Lab (CSAIL) at MIT.

Kellis is known for his contributions to genomics, human genetics, epigenomics, gene regulation, genome evolution, disease mechanism, and single-cell genomics. He co-led the NIH Roadmap Epigenomics Project effort to create a comprehensive map of the human epigenome, the comparative analysis of 29 mammals to create a comprehensive map of conserved elements in the human genome, the ENCODE, GENCODE, and modENCODE projects to characterize the genes, non-coding elements, and circuits of the human genome and model organisms. A major focus of his work is understanding the effects of genetic variations on human disease, with contributions to obesity, diabetes, Alzheimer's disease, schizophrenia, and cancer. Provided by Wikipedia
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  1. 1
    CoCoA-diff: counterfactual inference for single-cell gene expression analysis

    CoCoA-diff: counterfactual inference for single-cell gene expression analysis by Yongjin P. Park, Manolis Kellis

    Published 2021-08-01
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  2. 2
    HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants

    HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants by Ward, Lucas D., Manolis, Kellis

    Published 2012
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  3. 3
    A multiresolution framework to characterize single-cell state landscapes

    A multiresolution framework to characterize single-cell state landscapes by Shahin Mohammadi, Jose Davila-Velderrain, Manolis Kellis

    Published 2020-10-01
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  4. 4
    Error and error mitigation in low-coverage genome assemblies.

    Error and error mitigation in low-coverage genome assemblies. by Melissa J Hubisz, Michael F Lin, Manolis Kellis, Adam Siepel

    Published 2011-02-01
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  5. 5
    Evidence of reduced recombination rate in human regulatory domains

    Evidence of reduced recombination rate in human regulatory domains by Yaping Liu, Abhishek Sarkar, Pouya Kheradpour, Jason Ernst, Manolis Kellis

    Published 2017-10-01
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  6. 6
    Performance and scalability of discriminative metrics for comparative gene identification in 12 Drosophila genomes.

    Performance and scalability of discriminative metrics for comparative gene identification in 12 Drosophila genomes. by Michael F Lin, Ameya N Deoras, Matthew D Rasmussen, Manolis Kellis

    Published 2008-04-01
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  7. 7
    Evidence for a novel overlapping coding sequence in POLG initiated at a CUG start codon

    Evidence for a novel overlapping coding sequence in POLG initiated at a CUG start codon by Yousuf A. Khan, Irwin Jungreis, James C. Wright, Jonathan M. Mudge, Jyoti S. Choudhary, Andrew E. Firth, Manolis Kellis

    Published 2020-03-01
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  8. 8
    RFECS: a random-forest based algorithm for enhancer identification from chromatin state.

    RFECS: a random-forest based algorithm for enhancer identification from chromatin state. by Nisha Rajagopal, Wei Xie, Yan Li, Uli Wagner, Wei Wang, John Stamatoyannopoulos, Jason Ernst, Manolis Kellis, Bing Ren

    Published 2013-01-01
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  9. 9
    High-resolution genome-wide functional dissection of transcriptional regulatory regions and nucleotides in human

    High-resolution genome-wide functional dissection of transcriptional regulatory regions and nucleotides in human by Xinchen Wang, Liang He, Sarah M. Goggin, Alham Saadat, Li Wang, Nasa Sinnott-Armstrong, Melina Claussnitzer, Manolis Kellis

    Published 2018-12-01
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  10. 10
    Leveraging single-cell ATAC-seq and RNA-seq to identify disease-critical fetal and adult brain cell types

    Leveraging single-cell ATAC-seq and RNA-seq to identify disease-critical fetal and adult brain cell types by Samuel S. Kim, Buu Truong, Karthik Jagadeesh, Kushal K. Dey, Amber Z. Shen, Soumya Raychaudhuri, Manolis Kellis, Alkes L. Price

    Published 2024-01-01
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  11. 11
    Exome-wide age-of-onset analysis reveals exonic variants in ERN1 and SPPL2C associated with Alzheimer’s disease

    Exome-wide age-of-onset analysis reveals exonic variants in ERN1 and SPPL2C associated with Alzheimer’s disease by Liang He, Yury Loika, Yongjin Park, Genotype Tissue Expression (GTEx) consortium, David A. Bennett, Manolis Kellis, Alexander M. Kulminski, for the Alzheimer’s Disease Neuroimaging Initiative

    Published 2021-02-01
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  12. 12
    Transcriptional vulnerabilities of striatal neurons in human and rodent models of Huntington’s disease

    Transcriptional vulnerabilities of striatal neurons in human and rodent models of Huntington’s disease by Ayano Matsushima, Sergio Sebastian Pineda, Jill R. Crittenden, Hyeseung Lee, Kyriakitsa Galani, Julio Mantero, Geoffrey Tombaugh, Manolis Kellis, Myriam Heiman, Ann M. Graybiel

    Published 2023-01-01
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  13. 13
    Linking DNA Methyltransferases to Epigenetic Marks and Nucleosome Structure Genome-wide in Human Tumor Cells

    Linking DNA Methyltransferases to Epigenetic Marks and Nucleosome Structure Genome-wide in Human Tumor Cells by Bilian Jin, Jason Ernst, Rochelle L. Tiedemann, Hongyan Xu, Suhas Sureshchandra, Manolis Kellis, Stephen Dalton, Chen Liu, Jeong-Hyeon Choi, Keith D. Robertson

    Published 2012-11-01
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  14. 14
    Human Primordial Germ Cells Are Specified from Lineage-Primed Progenitors

    Human Primordial Germ Cells Are Specified from Lineage-Primed Progenitors by Di Chen, Na Sun, Lei Hou, Rachel Kim, Jared Faith, Marianna Aslanyan, Yu Tao, Yi Zheng, Jianping Fu, Wanlu Liu, Manolis Kellis, Amander Clark

    Published 2019-12-01
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  15. 15
    New approaches for understanding the potential role of microbes in Alzheimer's disease

    New approaches for understanding the potential role of microbes in Alzheimer's disease by Heather E. Whitson, William A. Banks, Monica M. Diaz, Bess Frost, Manolis Kellis, Richard Lathe, Kenneth E. Schmader, Serena S. Spudich, Rudolph Tanzi, Gwenn Garden

    Published 2024-03-01
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  16. 16
    Chromatin Accessibility Impacts Transcriptional Reprogramming in Oocytes

    Chromatin Accessibility Impacts Transcriptional Reprogramming in Oocytes by Kei Miyamoto, Khoi T. Nguyen, George E. Allen, Jerome Jullien, Dinesh Kumar, Tomoki Otani, Charles R. Bradshaw, Frederick J. Livesey, Manolis Kellis, John B. Gurdon

    Published 2018-07-01
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  17. 17
    Sharing and Specificity of Co-expression Networks across 35 Human Tissues.

    Sharing and Specificity of Co-expression Networks across 35 Human Tissues. by Emma Pierson, GTEx Consortium, Daphne Koller, Alexis Battle, Sara Mostafavi, Kristin G Ardlie, Gad Getz, Fred A Wright, Manolis Kellis, Simona Volpi, Emmanouil T Dermitzakis

    Published 2015-05-01
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  18. 18
    Rabies virus-based barcoded neuroanatomy resolved by single-cell RNA and in situ sequencing

    Rabies virus-based barcoded neuroanatomy resolved by single-cell RNA and in situ sequencing by Aixin Zhang, Lei Jin, Shenqin Yao, Makoto Matsuyama, Cindy TJ van Velthoven, Heather Anne Sullivan, Na Sun, Manolis Kellis, Bosiljka Tasic, Ian Wickersham, Xiaoyin Chen

    Published 2024-02-01
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  19. 19
    High-throughput 5′ UTR engineering for enhanced protein production in non-viral gene therapies

    High-throughput 5′ UTR engineering for enhanced protein production in non-viral gene therapies by Jicong Cao, Eva Maria Novoa, Zhizhuo Zhang, William C. W. Chen, Dianbo Liu, Gigi C. G. Choi, Alan S. L. Wong, Claudia Wehrspaun, Manolis Kellis, Timothy K. Lu

    Published 2021-07-01
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  20. 20
    Single-cell transcriptomic atlas of the human retina identifies cell types associated with age-related macular degeneration

    Single-cell transcriptomic atlas of the human retina identifies cell types associated with age-related macular degeneration by Madhvi Menon, Shahin Mohammadi, Jose Davila-Velderrain, Brittany A. Goods, Tanina D. Cadwell, Yu Xing, Anat Stemmer-Rachamimov, Alex K. Shalek, John Christopher Love, Manolis Kellis, Brian P. Hafler

    Published 2019-10-01
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