Case report: JAK inhibition as promising treatment option of fatal RVCLS due to TREX1 mutation (pVAL235Glyfs*6) by Friederike Ufer, Susanne M. Ziegler, Marcus Altfeld, Manuel A. Friese

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A glibenclamide-sensitive TRPM4-mediated component of CA1 excitatory postsynaptic potentials appears in experimental autoimmune encephalomyelitis by Brenna C. Fearey, Lars Binkle, Daniel Mensching, Christian Schulze, Christian Lohr, Manuel A. Friese, Thomas G. Oertner, Christine E. Gee

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Neuronal Adenosine A1 Receptor is Critical for Olfactory Function but Unable to Attenuate Olfactory Dysfunction in Neuroinflammation by Charlotte Schubert, Kristina Schulz, Simone Träger, Anna-Lena Plath, Asina Omriouate, Sina C. Rosenkranz, Fabio Morellini, Manuel A. Friese, Daniela Hirnet

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GPR52 regulates cAMP in T cells but is dispensable for encephalitogenic responses by Paula F. Krieg, Jana K. Sonner, Roberta Kurelic, Jan Broder Engler, Marlena F. Scharenberg, Simone Bauer, Viacheslav O. Nikolaev, Manuel A. Friese

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A P2rx7 Passenger Mutation Affects the Vitality and Function of T cells in Congenic Mice by Marco Er-Lukowiak, Yinghui Duan, Francois Rassendren, Lauriane Ulmann, Annette Nicke, Friederike Ufer, Manuel A. Friese, Friedrich Koch-Nolte, Tim Magnus, Björn Rissiek

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Upregulation of Phosphodiesterase 2A Augments T Cell Activation by Changing cGMP/cAMP Cross-Talk by Roberta Kurelic, Paula F. Krieg, Jana K. Sonner, Gloria Bhaiyan, Gustavo C. Ramos, Gustavo C. Ramos, Stefan Frantz, Stefan Frantz, Manuel A. Friese, Viacheslav O. Nikolaev, Viacheslav O. Nikolaev

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A2A adenosine receptor-driven cAMP signaling in olfactory bulb astrocytes is unaffected in experimental autoimmune encephalomyelitis by Marina Wendlandt, Alina J. Kürten, Antonia Beiersdorfer, Charlotte Schubert, Kiana Samad-Yazdtchi, Jessica Sauer, M. Carolina Pinto, Kristina Schulz, Manuel A. Friese, Christine E. Gee, Daniela Hirnet, Christian Lohr

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TRPV4-Mediated Regulation of the Blood Brain Barrier Is Abolished During Inflammation by Sina C. Rosenkranz, Artem Shaposhnykov, Oliver Schnapauff, Lisa Epping, Vanessa Vieira, Karsten Heidermann, Benjamin Schattling, Volodymyr Tsvilovskyy, Wolfgang Liedtke, Sven G. Meuth, Marc Freichel, Mathias Gelderblom, Manuel A. Friese

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Activity-regulated cytoskeleton-associated protein/activity-regulated gene 3.1 (Arc/Arg3.1) enhances dendritic cell vaccination in experimental melanoma by Xin-Wen Zhang, Katrin Huck, Kristine Jähne, Frederik Cichon, Jana K. Sonner, Friederike Ufer, Simone Bauer, Marcel Seungsu Woo, Ed Green, Kevin Lu, Michael Kilian, Manuel A. Friese, Michael Platten, Katharina Sahm

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Neandertal introgression partitions the genetic landscape of neuropsychiatric disorders and associated behavioral phenotypes by Michael Dannemann, Yuri Milaneschi, Danat Yermakovich, Victoria Stiglbauer, Hanna Maria Kariis, Kristi Krebs, Manuel A. Friese, Christian Otte, Estonian Biobank Research Team, Kelli Lehto, Brenda W. J. H. Penninx, Janet Kelso, Stefan M. Gold

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Prenatal Administration of Betamethasone Causes Changes in the T Cell Receptor Repertoire Influencing Development of Autoimmunity by Anna Gieras, Christina Gehbauer, David Perna-Barrull, Jan Broder Engler, Ines Diepenbruck, Laura Glau, Simon A. Joosse, Nora Kersten, Stefanie Klinge, Hans-Willi Mittrücker, Manuel A. Friese, Marta Vives-Pi, Marta Vives-Pi, Eva Tolosa

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Contribution of NAADP to Glutamate-Evoked Changes in Ca2+ Homeostasis in Mouse Hippocampal Neurons by Julia Hermann, Melanie Bender, Dagmar Schumacher, Dagmar Schumacher, Marcel S. Woo, Artem Shaposhnykov, Sina C. Rosenkranz, Vladimir Kuryshev, Vladimir Kuryshev, Chris Meier, Andreas H. Guse, Manuel A. Friese, Marc Freichel, Marc Freichel, Volodymyr Tsvilovskyy, Volodymyr Tsvilovskyy

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T Cell Phenotype and T Cell Receptor Repertoire in Patients with Major Depressive Disorder by Kostas Patas, Anne Willing, Cüneyt Demiralay, Jan Broder Engler, Andreea Lupu, Andreea Lupu, Caren Ramien, Tobias Schäfer, Christian Gach, Laura Stumm, Kenneth Chan, Marissa Vignali, Petra C. Arck, Manuel A. Friese, Ole Pless, Klaus Wiedemann, Agorastos Agorastos, Stefan M. Gold, Stefan M. Gold

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Enhancing mitochondrial activity in neurons protects against neurodegeneration in a mouse model of multiple sclerosis by Sina C Rosenkranz, Artem A Shaposhnykov, Simone Träger, Jan Broder Engler, Maarten E Witte, Vanessa Roth, Vanessa Vieira, Nanne Paauw, Simone Bauer, Celina Schwencke-Westphal, Charlotte Schubert, Lukas Can Bal, Benjamin Schattling, Ole Pless, Jack van Horssen, Marc Freichel, Manuel A Friese

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Mucosal-associated invariant T cells contribute to suppression of inflammatory myeloid cells in immune-mediated kidney disease by Ann-Christin Gnirck, Marie-Sophie Philipp, Alex Waterhölter, Malte Wunderlich, Nikhat Shaikh, Virginia Adamiak, Lena Henneken, Tobias Kautz, Tingting Xiong, Daniela Klaus, Pascal Tomczyk, Mohamad M. Al-Bahra, Dirk Menche, Mark Walkenhorst, Olivier Lantz, Anne Willing, Manuel A. Friese, Tobias B. Huber, Christian F. Krebs, Ulf Panzer, Christian Kurts, Jan-Eric Turner

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Alterations of NK Cell Phenotype During Pregnancy in Multiple Sclerosis by Anne Wisgalla, Anne Wisgalla, Caren Ramien, Mathias Streitz, Mathias Streitz, Mathias Streitz, Stephan Schlickeiser, Stephan Schlickeiser, Andreea-Roxana Lupu, Anke Diemert, Eva Tolosa, Petra C. Arck, Judith Bellmann-Strobl, Judith Bellmann-Strobl, Nadja Siebert, Christoph Heesen, Friedemann Paul, Friedemann Paul, Manuel A. Friese, Carmen Infante-Duarte, Stefan M. Gold, Stefan M. Gold, Stefan M. Gold

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Metabolomic Profiles for Primary Progressive Multiple Sclerosis Stratification and Disease Course Monitoring by Daniel Stoessel, Daniel Stoessel, Daniel Stoessel, Jan-Patrick Stellmann, Jan-Patrick Stellmann, Anne Willing, Birte Behrens, Sina C. Rosenkranz, Sina C. Rosenkranz, Sibylle C. Hodecker, Sibylle C. Hodecker, Klarissa H. Stürner, Klarissa H. Stürner, Stefanie Reinhardt, Sabine Fleischer, Christian Deuschle, Walter Maetzler, Walter Maetzler, Daniela Berg, Daniela Berg, Christoph Heesen, Christoph Heesen, Dirk Walther, Dirk Walther, Nicolas Schauer, Manuel A. Friese, Ole Pless

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Autologous haematopoietic stem cell transplantation for multiple sclerosis: a position paper and registry outline by Antonios Bayas, Achim Berthele, Norbert Blank, Peter Dreger, Simon Faissner, Manuel A. Friese, Lisa-Ann Gerdes, Oliver Martin Grauer, Vivien Häussler, Christoph Heesen, Dietlinde Janson, Mirjam Korporal-Kuhnke, Markus Kowarik, Nikolaus Kröger, Jan D. Lünemann, Roland Martin, Uwe Meier, Sven Meuth, Paolo Muraro, Michael Platten, Lucas Schirmer, Klarissa Hanja Stürner, Jan Patrick Stellmann, Christof Scheid, Florian Then Bergh, Clemens Warnke, Brigitte Wildemann, Tjalf Ziemssen

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14-3-3 $$\upzeta /\updelta$$ ζ / δ -reported early synaptic injury in Alzheimer’s disease is independently mediated by sTREM2 by Marcel S. Woo, Johanna Nilsson, Joseph Therriault, Nesrine Rahmouni, Ann Brinkmalm, Andrea L. Benedet, Nicholas J. Ashton, Arthur C. Macedo, Stijn Servaes, Yi-Ting Wang, Cécile Tissot, Jaime Fernandez Arias, Seyyed Ali Hosseini, Mira Chamoun, Firoza Z. Lussier, Thomas K. Karikari, Jenna Stevenson, Christina Mayer, João Pedro Ferrari-Souza, Eliane Kobayashi, Gassan Massarweh, Manuel A. Friese, Tharick A. Pascoal, Serge Gauthier, Henrik Zetterberg, Kaj Blennow, Pedro Rosa-Neto

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Comparison of immunoassay- with mass spectrometry-derived p-tau quantification for the detection of Alzheimer’s disease pathology by Joseph Therriault, Marcel S. Woo, Gemma Salvadó, Johan Gobom, Thomas K. Karikari, Shorena Janelidze, Stijn Servaes, Nesrine Rahmouni, Cécile Tissot, Nicholas J. Ashton, Andréa Lessa Benedet, Laia Montoliu-Gaya, Arthur C. Macedo, Firoza Z. Lussier, Jenna Stevenson, Paolo Vitali, Manuel A. Friese, Gassan Massarweh, Jean-Paul Soucy, Tharick A. Pascoal, Erik Stomrud, Sebastian Palmqvist, Niklas Mattsson-Carlgren, Serge Gauthier, Henrik Zetterberg, Oskar Hansson, Kaj Blennow, Pedro Rosa-Neto

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