PB1708: CHARACTERIZATION OF GLOBAL CYTOGENOMICS FEATURES IN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA BY OPTICAL GENOME MAPPING by Elena Garcia Sanchez, Jorge García, Ana Gomez, Reyes Giménez, David Ruano, Maitane Andion, Lorea Abad, Ana Castillo, Luis Madero, Manuel Ramirez Orellana

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P336: PREDICTIVE SCORES FOR RELAPSE AND PROGRESSION DISEASE IN PEDIATRIC ACUTE LYMPHOBLASTIC LEUKEMIA PATIENTS BASED ON OPTICAL GENOME MAPPING TECHNOLOGY by Jorge Garcia Martinez, Elena Garcia Sanchez, Ana Gomez, Reyes Giménez, Ana Benito, Blanca Herrero, Lorea Abad, Ana Castillo, Luis Madero, Manuel Ramirez Orellana

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Mesenchymal stromal cells derived from the bone marrow of acute lymphoblastic leukemia patients show altered BMP4 production: correlations with the course of disease. by Ángeles Vicente López, Miriam Nohemí Vázquez García, Gustavo J Melen, Ana Entrena Martínez, Isabel Cubillo Moreno, Javier García-Castro, Manuel Ramírez Orellana, Agustín Gregorio Zapata González

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TIM3, a human acute myeloid leukemia stem cell marker, does not enrich for leukemia-initiating stem cells in B-cell acute lymphoblastic leukemia by Clara Bueno, Alba Martínez, Paola Alejandra Romecin, Samanta Romina Zanetti, Ricky Tirtakusuma, Eulalia Genesca, Mireia Camós, Manuel Ramírez-Orellana, Eduardo Anguita, Paola Ballerini, Franco Locatelli, José Luis Fuster, Pablo Menéndez

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Increased Hypothalamic Anti-Inflammatory Mediators in Non-Diabetic Insulin Receptor Substrate 2-Deficient Mice by María Vinaixa, Sandra Canelles, África González-Murillo, Vítor Ferreira, Diana Grajales, Santiago Guerra-Cantera, Ana Campillo-Calatayud, Manuel Ramírez-Orellana, Óscar Yanes, Laura M. Frago, Ángela M. Valverde, Vicente Barrios

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The Netrin-4/Laminin γ1/Neogenin-1 complex mediates migration in SK-N-SH neuroblastoma cells by Andrea A. Villanueva, Sofía Puvogel, Pablo Lois, Ernesto Muñoz-Palma, Manuel Ramírez Orellana, Fabiana Lubieniecki, Fernando Casco Claro, Iván Gallegos, Javier García-Castro, Pilar Sanchez-Gomez, Vicente A. Torres, Verónica Palma

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The Netrin-1-Neogenin-1 signaling axis controls neuroblastoma cell migration via integrin-β1 and focal adhesion kinase activation by Andrea A. Villanueva, Pilar Sanchez-Gomez, Ernesto Muñoz-Palma, Sofía Puvogel, Bárbara S. Casas, Cecilia Arriagada, Isaac Peña-Villalobos, Pablo Lois, Manuel Ramírez Orellana, Fabiana Lubieniecki, Fernando Casco Claro, Iván Gallegos, Javier García-Castro, Vicente A. Torres, Verónica Palma

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The shape of cancer relapse: Topological data analysis predicts recurrence in paediatric acute lymphoblastic leukaemia. by Salvador Chulián, Bernadette J Stolz, Álvaro Martínez-Rubio, Cristina Blázquez Goñi, Juan F Rodríguez Gutiérrez, Teresa Caballero Velázquez, Águeda Molinos Quintana, Manuel Ramírez Orellana, Ana Castillo Robleda, José Luis Fuster Soler, Alfredo Minguela Puras, María V Martínez Sánchez, María Rosa, Víctor M Pérez-García, Helen M Byrne

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CD4+ tumor-infiltrating lymphocytes secreting T cell-engagers induce regression of autologous patient-derived non-small cell lung cancer xenografts by Anaïs Jiménez-Reinoso, Magdalena Molero-Abraham, Cristina Cirauqui, Belén Blanco, Eva M. Garrido-Martin, Daniel Nehme-Álvarez, Carmen Domínguez-Alonso, Ángel Ramírez-Fernández, Laura Díez-Alonso, Ángel Nuñez-Buiza, África González-Murillo, Raquel Tobes, Eduardo Pareja, Manuel Ramírez-Orellana, José Luis Rodriguez-Peralto, Irene Ferrer, Jon Zugazagoitia, Luis Paz-Ares, Luis Álvarez-Vallina

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Clonal heterogeneity and rates of specific chromosome gains are risk predictors in childhood high‐hyperdiploid B‐cell acute lymphoblastic leukemia by Mireia Ramos‐Muntada, Juan L. Trincado, Joan Blanco, Clara Bueno, Virginia C. Rodríguez‐Cortez, Alex Bataller, Belén López‐Millán, Claire Schwab, Margarita Ortega, Pablo Velasco, Maria L. Blanco, Josep Nomdedeu, Manuel Ramírez‐Orellana, Alfredo Minguela, Jose L. Fuster, Esther Cuatrecasas, Mireia Camós, Paola Ballerini, Gabriele Escherich, Judith Boer, Monique DenBoer, Jesús M. Hernández‐Rivas, Maria J. Calasanz, Giovanni Cazzaniga, Christine J. Harrison, Pablo Menéndez, Oscar Molina

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Immune stress suppresses innate immune signaling in preleukemic precursor B-cells to provoke leukemia in predisposed mice by Marta Isidro-Hernández, Ana Casado-García, Ninad Oak, Silvia Alemán-Arteaga, Belén Ruiz-Corzo, Jorge Martínez-Cano, Andrea Mayado, Elena G. Sánchez, Oscar Blanco, Ma Luisa Gaspar, Alberto Orfao, Diego Alonso-López, Javier De Las Rivas, Susana Riesco, Pablo Prieto-Matos, África González-Murillo, Francisco Javier García Criado, María Begoña García Cenador, Manuel Ramírez-Orellana, Belén de Andrés, Carolina Vicente-Dueñas, César Cobaleda, Kim E. Nichols, Isidro Sánchez-García

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Measurable Residual Disease Assessed by Flow-Cytometry Is a Stable Prognostic Factor for Pediatric T-Cell Acute Lymphoblastic Leukemia in Consecutive SEHOP Protocols Whereas the Im... by Nerea Vega-García, Nerea Vega-García, Sara Perez-Jaume, Elena Esperanza-Cebollada, Elena Esperanza-Cebollada, Clara Vicente-Garcés, Clara Vicente-Garcés, Montserrat Torrebadell, Montserrat Torrebadell, Montserrat Torrebadell, Antonio Jiménez-Velasco, Margarita Ortega, Marta Llop, Marta Llop, Lorea Abad, José Manuel Vagace, Alfredo Minguela, Marta Pratcorona, Joaquín Sánchez-Garcia, Clara B. García-Calderón, María Teresa Gómez-Casares, Estela Martín-Clavero, Adela Escudero, Marta Riñón Martinez-Gallo, Luz Muñoz, María Rosario Velasco, Marina García-Morin, Albert Català, Albert Català, Albert Català, Antonia Pascual, Pablo Velasco, José Mª. Fernández, Alvaro Lassaletta, José Luis Fuster, Isabel Badell, Águeda Molinos-Quintana, Antonio Molinés, Pilar Guerra-García, Pilar Guerra-García, Antonio Pérez-Martínez, Antonio Pérez-Martínez, Miriam García-Abós, Reyes Robles Ortiz, Sandra Pisa, Rosa Adán, Cristina Díaz de Heredia, José Luis Dapena, José Luis Dapena, Susana Rives, Susana Rives, Susana Rives, Manuel Ramírez-Orellana, Mireia Camós, Mireia Camós, Mireia Camós

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Newer generations of multi-target CAR and STAb-T immunotherapeutics: NEXT CART Consortium as a cooperative effort to overcome current limitations by Beatriz Martín-Antonio, Belén Blanco, África González-Murillo, Laura Hidalgo, Jordi Minguillón, Gema Pérez-Chacón, Next Generation CART MAD Consortium, Jordi Minguillón, Lucía Fernández, Halin Bareke, Andrés París-Muñoz, Adriana Mañas, Cristina Aguirre-Portolés, Alfonso Navarro-Zapata, Carmen Mestre-Durán, Marta Ibáñez-Navarro, Laura Clares-Villa, Sara Naharro, Antonio Perez-Martinez, Marcos Aldea, María Gaibar, Javier Ruiz-Navarro, Manuel Izquierdo, Juan M. Zapata, África González Murillo, Elena García Sánchez, Jorge García Martínez, Alba Rubio San Simón, Blanca Herrero, Gonzalo García Aguilera, Beatriz Horcajo Morera, Manuel Ramírez Orellana, Belén Blanco-Durango, Anais Jiménez-Reinoso, Rodrigo Lázaro-Gorines, Ivana Zagorac, Antonio Tapia Galisteo, Ángel Ramirez-Fernández, Laura Díez-Alonso, Carmen Dominguez-Alonso, Ainhoa Erce-Llamazares, Oana Hangiu, Laura Rubio Pérez, Marina Gómez Rosel, Alejandro Segura Tudela, Javier Arroyo-Ródena, Luis Álvarez-Vallina, Miguel Ángel Rodríguez Milla, Patricia García Rodríguez, Beatriz Somovilla Crespo, Javier García-Castro, Esperanza Esquinas Tarifa, Juana Serrano-López, Pilar Llamas-Sillero, Beatriz Martin-Antonio

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