A rare case of relapsed multiple myeloma with aberrant T‐cell antigen expression and skin plasmacytomas by Catherine S.Y. Lecat, Manuel Rodriguez‐Justo, Dominic Patel, Kwee Yong, Xenofon Papanikolaou

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Deep Learning Applied to Raman Spectroscopy for the Detection of Microsatellite Instability/MMR Deficient Colorectal Cancer by Nathan Blake, Riana Gaifulina, Lewis D. Griffin, Ian M. Bell, Manuel Rodriguez-Justo, Geraint M. H. Thomas

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Prognostic biomarkers to identify patients likely to develop severe Crohn’s disease: a systematic review by Steve Halligan, Darren Boone, Lucinda Archer, Tariq Ahmad, Stuart Bloom, Manuel Rodriguez-Justo, Stuart A Taylor, Sue Mallett

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A SIMPLI (Single-cell Identification from MultiPLexed Images) approach for spatially-resolved tissue phenotyping at single-cell resolution by Michele Bortolomeazzi, Lucia Montorsi, Damjan Temelkovski, Mohamed Reda Keddar, Amelia Acha-Sagredo, Michael J. Pitcher, Gianluca Basso, Luigi Laghi, Manuel Rodriguez-Justo, Jo Spencer, Francesca D. Ciccarelli

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The natural history of low‐grade dysplasia in Barrett's esophagus and risk factors for progression by Mohamed Hussein, Vinay Sehgal, Sarmed Sami, Paul Bassett, Rami Sweis, David Graham, Andrea Telese, Danielle Morris, Manuel Rodriguez‐Justo, Marnix Jansen, Marco Novelli, Matthew Banks, Laurence B Lovat, Rehan Haidry

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Patients with genetically heterogeneous synchronous colorectal cancer carry rare damaging germline mutations in immune-related genes by Matteo Cereda, Gennaro Gambardella, Lorena Benedetti, Fabio Iannelli, Dominic Patel, Gianluca Basso, Rosalinda F. Guerra, Thanos P. Mourikis, Ignazio Puccio, Shruti Sinha, Luigi Laghi, Jo Spencer, Manuel Rodriguez-Justo, Francesca D. Ciccarelli

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Self-supervised deep learning for highly efficient spatial immunophenotypingResearch in context by Hanyun Zhang, Khalid AbdulJabbar, Tami Grunewald, Ayse U. Akarca, Yeman Hagos, Faranak Sobhani, Catherine S.Y. Lecat, Dominic Patel, Lydia Lee, Manuel Rodriguez-Justo, Kwee Yong, Jonathan A. Ledermann, John Le Quesne, E. Shelley Hwang, Teresa Marafioti, Yinyin Yuan

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Identification of a Novel HIF-1α-αMβ2 Integrin-NET Axis in Fibrotic Interstitial Lung Disease by Akif A. Khawaja, Akif A. Khawaja, Deborah L. W. Chong, Jagdeep Sahota, Theresia A. Mikolasch, Theresia A. Mikolasch, Charis Pericleous, Vera M. Ripoll, Helen L. Booth, Saif Khan, Manuel Rodriguez-Justo, Ian P. Giles, Joanna C. Porter, Joanna C. Porter

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CD229 (Ly9) a Novel Biomarker for B-Cell Malignancies and Multiple Myeloma by Giovanna Roncador, Joan Puñet-Ortiz, Lorena Maestre, Luis Gerardo Rodríguez-Lobato, Scherezade Jiménez, Ana Isabel Reyes-García, Álvaro García-González, Juan F. García, Miguel Ángel Piris, Santiago Montes-Moreno, Manuel Rodríguez-Justo, Mari-Pau Mena, Carlos Fernández de Larrea, Pablo Engel

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Quality assurance guidance for scoring and reporting for pathologists and laboratories undertaking clinical trial work by Max Robinson, Jacqueline James, Gareth Thomas, Nicholas West, Louise Jones, Jessica Lee, Karin Oien, Alex Freeman, Clare Craig, Philip Sloan, Philip Elliot, Maggie Cheang, Manuel Rodriguez‐Justo, Clare Verrill, on behalf of the UK National Cancer Research Institute (NCRI) Cellular‐Molecular Pathology (CM‐Path) clinical trials working group

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Immunosuppressive niche engineering at the onset of human colorectal cancer by Chandler D. Gatenbee, Ann-Marie Baker, Ryan O. Schenck, Maximilian Strobl, Jeffrey West, Margarida P. Neves, Sara Yakub Hasan, Eszter Lakatos, Pierre Martinez, William C. H. Cross, Marnix Jansen, Manuel Rodriguez-Justo, Christopher J. Whelan, Andrea Sottoriva, Simon Leedham, Mark Robertson-Tessi, Trevor A. Graham, Alexander R. A. Anderson

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Robust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolution by Ann-Marie Baker, Weini Huang, Xiao-Ming Mindy Wang, Marnix Jansen, Xiao-Jun Ma, Jeffrey Kim, Courtney M. Anderson, Xingyong Wu, Liuliu Pan, Nan Su, Yuling Luo, Enric Domingo, Timon Heide, Andrea Sottoriva, Annabelle Lewis, Andrew D. Beggs, Nicholas A. Wright, Manuel Rodriguez-Justo, Emily Park, Ian Tomlinson, Trevor A. Graham

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Magnetic resonance enterography compared with ultrasonography in newly diagnosed and relapsing Crohn’s disease patients: the METRIC diagnostic accuracy study by Stuart A Taylor, Sue Mallett, Gauraang Bhatnagar, Stephen Morris, Laura Quinn, Florian Tomini, Anne Miles, Rachel Baldwin-Cleland, Stuart Bloom, Arun Gupta, Peter John Hamlin, Ailsa L Hart, Antony Higginson, Ilan Jacobs, Sara McCartney, Charles D Murray, Andrew AO Plumb, Richard C Pollok, Manuel Rodriguez-Justo, Zainib Shabir, Andrew Slater, Damian Tolan, Simon Travis, Alastair Windsor, Peter Wylie, Ian Zealley, Steve Halligan

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Limited efficacy of APRIL CAR in patients with multiple myeloma indicate challenges in the use of natural ligands for CAR T-cell therapy by Simon Thomas, Julia Taylor, Manuel Rodriguez-Justo, Mathieu Ferrari, Shimobi Onuoha, Sonja Zweegman, Rakesh Popat, Lydia Lee, Wen Chean Lim, Daria Galas-Filipowicz, Kent Fung, Dominic Patel, Zulaikha Akbar, Elena Alvarez Mediavilla, Patrycja Wawrzyniecka, Debarati Shome, Rogier M Reijmers, Trillian Gregg, Leigh Wood, William Day, Virginie Cerec, Shaun Cordoba, Nushmia Khokhar, Vijay Peddareddigari, Muhammad Al-Hajj, Jim Cavet, Kwee Youg, Martin Pule

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Evaluation of PSA and PSA Density in a Multiparametric Magnetic Resonance Imaging-Directed Diagnostic Pathway for Suspected Prostate Cancer: The INNOVATE Trial by Hayley Pye, Saurabh Singh, Joseph M. Norris, Lina M. Carmona Echeverria, Vasilis Stavrinides, Alistair Grey, Eoin Dinneen, Elly Pilavachi, Joey Clemente, Susan Heavey, Urszula Stopka-Farooqui, Benjamin S. Simpson, Elisenda Bonet-Carne, Dominic Patel, Peter Barker, Keith Burling, Nicola Stevens, Tony Ng, Eleftheria Panagiotaki, David Hawkes, Daniel C. Alexander, Manuel Rodriguez-Justo, Aiman Haider, Alex Freeman, Alex Kirkham, David Atkinson, Clare Allen, Greg Shaw, Teresita Beeston, Mrishta Brizmohun Appayya, Arash Latifoltojar, Edward W. Johnston, Mark Emberton, Caroline M. Moore, Hashim U. Ahmed, Shonit Punwani, Hayley C. Whitaker

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Development and validation of a risk prediction model to diagnose Barrett's oesophagus (MARK-BE): a case-control machine learning approach by Avi Rosenfeld, PhD, David G Graham, MBBS, Sarah Jevons, PhD, Jose Ariza, RGN, Daryl Hagan, MSc, Ash Wilson, BSc, Samuel J Lovat, Sarmed S Sami, MBBS, Omer F Ahmad, MBBS, Marco Novelli, ProfMBChB, Manuel Rodriguez Justo, MBBS, Alison Winstanley, MBBS, Eliyahu M Heifetz, PhD, Mordehy Ben-Zecharia, PhD, Uria Noiman, PhD, Rebecca C Fitzgerald, ProfMBChB, Peter Sasieni, ProfPhD, Laurence B Lovat, ProfMBBS, Karen Coker, Wanfeng Zhao, Kathryn Brown, Beverley Haynes, Tara Nuckcheddy Grant, Massimiliano di Pietro, Eleanor Dewhurst, Bincy Alias, Leanne Mills, Caroline Wilson, Elizabeth Bird-Lieberman, Jan Bornschein, Yean Lim, Kareem Shariff, Roberto Cayado Lopez, Myrna Udarbe, Claire Shaw, Glynis Rose, Ian Sargeant, M Al-Izzi, Roisin Schimmel, Elizabeth Green, Morgan Moorghen, Reshma Kanani, Mariann Baulf, Jayne Butcher, Adil Butt, Steve Bown, Gideon Lipman, Rami Sweis, Vinay Sehgal, Matthew Banks, Rehan Haidry, John Louis-Auguste, Darina Kohoutova, Sarah Kerr, Victor Eneh, Nigel Butter, Haroon Miah, Rommel Butawan, Grace Adesina, Sabrina Holohan, Joan Idris, Nick Hayes, Shajahan Wahed, Nelson Kath Houghton, Marc Hopton, Anne Eastick, Debasis Majumdar, Kassem Manuf, Lyndsey Fieldson, Helen Bailey, Jacobo Fernandez-Sordo Ortiz, Mina Patel, Suzanne Henry, Samantha Warburton, Jonathan White, Lisa Gadeke, Beverley Longhurst, Richmond Abeseabe, Peter Basford, Rupam Bhattacharyya, Scott Elliot, Roisin Bevan, Carly Brown, Philippa Laverick, Gayle Clifford, Anita Gibbons, Julie Ingmire, Abdullah Mawas, Jacquelyn Harvey, Sharon Cave

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