NKG2H-Expressing T Cells Negatively Regulate Immune Responses by Daniela Dukovska, Daniel Fernández-Soto, Mar Valés-Gómez, Hugh T. Reyburn

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Editorial: The interaction of NKG2D and its ligands in health and diseases by Silvana Gaudieri, Silvana Gaudieri, Silvana Gaudieri, Hugh T. Reyburn, Mar Vales-Gomez, Chanvit Leelayuwat

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Elevated levels of cell-free NKG2D-ligands modulate NKG2D surface expression and compromise NK cell function in severe COVID-19 disease by Daniel Fernández-Soto, Álvaro F. García-Jiménez, José M. Casasnovas, Mar Valés-Gómez, Hugh T. Reyburn

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Natural Killer Anti-Tumor Activity Can Be Achieved by In Vitro Incubation With Heat-Killed BCG by Gloria Esteso, Nacho Aguiló, Esther Julián, Omodele Ashiru, Mei. M. Ho, Carlos Martín, Mar Valés-Gómez

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Impaired NK cell recognition of vemurafenib-treated melanoma cells is overcome by simultaneous application of histone deacetylase inhibitors by Sheila López-Cobo, Natalia Pieper, Carmen Campos-Silva, Eva M. García-Cuesta, Hugh T. Reyburn, Annette Paschen, Mar Valés-Gómez

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Standardising the preanalytical reporting of biospecimens to improve reproducibility in extracellular vesicle research – A GEIVEX study by José A. López‐Guerrero, Mar Valés‐Gómez, Francesc E. Borrás, Juan Manuel Falcón‐Pérez, María J. Vicent, María Yáñez‐Mó

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CyTOF analysis identifies unusual immune cells in urine of BCG-treated bladder cancer patients by Eva Castellano, Célia Samba, Gloria Esteso, Laura Simpson, Elena Vendrame, Eva M. García‐Cuesta, Sheila López‐Cobo, Mario Álvarez-Maestro, Mario Álvarez-Maestro, Ana Linares, Asier Leibar, Thanmayi Ranganath, Hugh T. Reyburn, Luis Martínez‐Piñeiro, Luis Martínez‐Piñeiro, Catherine Blish, Catherine Blish, Mar Valés‐Gómez, Mar Valés‐Gómez

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Immunoassays for scarce tumour-antigens in exosomes: detection of the human NKG2D-Ligand, MICA, in tetraspanin-containing nanovesicles from melanoma by Sheila López-Cobo, Carmen Campos-Silva, Amanda Moyano, Myriam Oliveira-Rodríguez, Annette Paschen, María Yáñez-Mó, María Carmen Blanco-López, Mar Valés-Gómez

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Characterization of a human anti-tumoral NK cell population expanded after BCG treatment of leukocytes by Eva M. García-Cuesta, Gloria Esteso, Omodele Ashiru, Sheila López-Cobo, Mario Álvarez-Maestro, Ana Linares, Mei M. Ho, Luis Martínez-Piñeiro, Hugh T. Reyburn, Mar Valés-Gómez

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A simple immunoassay for extracellular vesicle liquid biopsy in microliters of non-processed plasma by Carmen Campos-Silva, Yaiza Cáceres-Martell, Estela Sánchez-Herrero, Amaia Sandúa, Alexandra Beneitez-Martínez, Álvaro González, Mariano Provencio, Atocha Romero, Ricardo Jara-Acevedo, María Yáñez-Mó, Mar Valés‐Gómez

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MAPK inhibitors dynamically affect melanoma release of immune NKG2D-ligands, as soluble protein and extracellular vesicle-associated by Silvia López-Borrego, Carmen Campos-Silva, Amaia Sandúa, Tamara Camino, Lucía Téllez-Pérez, Estibaliz Alegre, Alexandra Beneitez, Ricardo Jara-Acevedo, Annette Paschen, María Pardo, Álvaro González, Mar Valés-Gómez

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BCG-activation of leukocytes is sufficient for the generation of donor-independent innate anti-tumor NK and γδ T-cells that can be further expanded in vitro by Gloria Esteso, María José Felgueres, Álvaro F. García-Jiménez, Christina Reyburn-Valés, Alberto Benguría, Enrique Vázquez, Hugh T. Reyburn, Nacho Aguiló, Carlos Martín, Eugenia Puentes, Ingrid Murillo, Esteban Rodríguez, Mar Valés-Gómez

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Novel intravesical bacterial immunotherapy induces rejection of BCG-unresponsive established bladder tumors by Julián Pardo, David Sancho, Denise Nardelli-Haefliger, Nacho Aguilo, Carlos Martín, Carlos del Fresno, Eduardo Moreo, Santiago Uranga, Ana Picó, Ana Belén Gómez, Ingrid Murillo, Eugenia Puentes, Esteban Rodríguez, Mar Vales-Gómez

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BCG Therapy of Bladder Cancer Stimulates a Prolonged Release of the Chemoattractant CXCL10 (IP10) in Patient Urine by Omodele Ashiru, Gloria Esteso, Eva M. García‐Cuesta, Eva Castellano, Celia Samba, Eva Escudero-López, Sheila López‐Cobo, Mario Álvarez-Maestro, Ana Linares, Mei M. Ho, Asier Leibar, Luis Martínez‐Piñeiro, Mar Valés‐Gómez

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Natural killer (NK) cell-derived extracellular-vesicle shuttled microRNAs control T cell responses by Sara G Dosil, Sheila Lopez-Cobo, Ana Rodriguez-Galan, Irene Fernandez-Delgado, Marta Ramirez-Huesca, Paula Milan-Rois, Milagros Castellanos, Alvaro Somoza, Manuel José Gómez, Hugh T Reyburn, Mar Vales-Gomez, Francisco Sánchez Madrid, Lola Fernandez-Messina

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Immune evasion by proteolytic shedding of natural killer group 2, member D ligands in Helicobacter pylori infection by Margit Anthofer, Markus Windisch, Rosa Haller, Sandra Ehmann, Sebastian Wrighton, Michael Miller, Lorenz Schernthanner, Iris Kufferath, Silvia Schauer, Barbara Jelušić, Sabine Kienesberger, Sabine Kienesberger, Ellen L. Zechner, Ellen L. Zechner, Gernot Posselt, Mar Vales-Gomez, Hugh T. Reyburn, Gregor Gorkiewicz, Gregor Gorkiewicz

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Intravenous administration of BCG in mice promotes natural killer and T cell-mediated antitumor immunity in the lung by Eduardo Moreo, Aitor Jarit-Cabanillas, Iñaki Robles-Vera, Santiago Uranga, Claudia Guerrero, Ana Belén Gómez, Pablo Mata-Martínez, Luna Minute, Miguel Araujo-Voces, María José Felgueres, Gloria Esteso, Iratxe Uranga-Murillo, Maykel Arias, Julián Pardo, Carlos Martín, Mar Valés-Gómez, Carlos del Fresno, David Sancho, Nacho Aguiló

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CD4+ T Cell Immune Specificity Changes After Vaccination in Healthy And COVID-19 Convalescent Subjects by Laura Esparcia-Pinedo, Pedro Martínez-Fleta, Noelia Ropero, Paula Vera-Tomé, Hugh T. Reyburn, José M. Casasnovas, José M. Rodríguez Frade, Mar Valés-Gómez, Carlos Vilches, Enrique Martín-Gayo, Enrique Martín-Gayo, Cecilia Muñoz-Calleja, Cecilia Muñoz-Calleja, Francisco Sanchez-Madrid, Francisco Sanchez-Madrid, Francisco Sanchez-Madrid, Arantzazu Alfranca, Arantzazu Alfranca, Arantzazu Alfranca

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NKG2D-CAR memory T cells target pediatric T-cell acute lymphoblastic leukemia in vitro and in vivo but fail to eliminate leukemia initiating cells by Marta Ibáñez-Navarro, Adrián Fernández, Adela Escudero, Gloria Esteso, Carmen Campos-Silva, Miguel Ángel Navarro-Aguadero, Alejandra Leivas, Alejandra Leivas, Beatriz Ruz Caracuel, Carlos Rodríguez-Antolín, Carlos Rodríguez-Antolín, Alejandra Ortiz, Alejandra Ortiz, Alfonso Navarro-Zapata, Carmen Mestre-Durán, Manuel Izquierdo, María Balaguer-Pérez, Cristina Ferreras, Joaquín Martínez-López, Joaquín Martínez-López, Mar Valés-Gómez, Antonio Pérez-Martínez, Antonio Pérez-Martínez, Antonio Pérez-Martínez, Lucía Fernández

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Extracellular Vesicles From Liver Progenitor Cells Downregulates Fibroblast Metabolic Activity and Increase the Expression of Immune-Response Related Molecules by Felix Royo, Felix Royo, Mikel Azkargorta, Jose L. Lavin, Marc Clos-Garcia, Ana R. Cortazar, Ana R. Cortazar, Monika Gonzalez-Lopez, Laura Barcena, Hernando A. del Portillo, Hernando A. del Portillo, Hernando A. del Portillo, María Yáñez-Mó, Antonio Marcilla, Antonio Marcilla, Francesc E. Borras, Francesc E. Borras, Francesc E. Borras, Hector Peinado, Isabel Guerrero, Mar Váles-Gómez, Unai Cereijo, Teresa Sardon, Ana M. Aransay, Ana M. Aransay, Felix Elortza, Felix Elortza, Juan M. Falcon-Perez, Juan M. Falcon-Perez, Juan M. Falcon-Perez

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