Cancer Genomics: Large-Scale Projects Translate into Therapeutic Advances. by Elaine R Mardis, Marc Ladanyi

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BAP1 missense mutation c.2054 A>T (p.E685V) completely disrupts normal splicing through creation of a novel 5' splice site in a human mesothelioma cell line. by Arianne Morrison, Yvonne Chekaluk, Ruben Bacares, Marc Ladanyi, Liying Zhang

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Functional copy-number alterations in cancer. by Barry S Taylor, Jordi Barretina, Nicholas D Socci, Penelope Decarolis, Marc Ladanyi, Matthew Meyerson, Samuel Singer, Chris Sander

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Somatic intronic TP53 c.375+5G mutations are a recurrent but under‐recognized mode of TP53 inactivation by M Herman Chui, Ciyu Yang, Nikita Mehta, Vikas Rai, Ahmet Zehir, Amir Momeni Boroujeni, Marc Ladanyi, Diana Mandelker

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Integrative subtype discovery in glioblastoma using iCluster. by Ronglai Shen, Qianxing Mo, Nikolaus Schultz, Venkatraman E Seshan, Adam B Olshen, Jason Huse, Marc Ladanyi, Chris Sander

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Desmoplastic small round cell tumor cancer stem cell-like cells resist chemotherapy but remain dependent on the EWSR1-WT1 oncoprotein by Justin W. Magrath, Hong-Jun Kang, Alifiani Hartono, Madelyn Espinosa-Cotton, Romel Somwar, Marc Ladanyi, Nai-Kong V. Cheung, Sean B. Lee

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Extracellular signal-regulated kinase mediates chromatin rewiring and lineage transformation in lung cancer by Yusuke Inoue, Ana Nikolic, Dylan Farnsworth, Rocky Shi, Fraser D Johnson, Alvin Liu, Marc Ladanyi, Romel Somwar, Marco Gallo, William W Lockwood

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Uterine mesenchymal tumors harboring ALK fusions and response to ALK-targeted therapy by Chrisann Kyi, Claire F. Friedman, Jennifer J. Mueller, Ryma Benayed, Marc Ladanyi, Maria Arcila, Soo Ryum Yang, Martee L. Hensley, Sarah Chiang

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KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib. by William Pao, Theresa Y Wang, Gregory J Riely, Vincent A Miller, Qiulu Pan, Marc Ladanyi, Maureen F Zakowski, Robert T Heelan, Mark G Kris, Harold E Varmus

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TP53 exon-6 truncating mutations produce separation of function isoforms with pro-tumorigenic functions by Nitin H Shirole, Debjani Pal, Edward R Kastenhuber, Serif Senturk, Joseph Boroda, Paola Pisterzi, Madison Miller, Gustavo Munoz, Marko Anderluh, Marc Ladanyi, Scott W Lowe, Raffaella Sordella

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High expression levels of total IGF-1R and sensitivity of NSCLC cells in vitro to an anti-IGF-1R antibody (R1507). by Yixuan Gong, Evelyn Yao, Ronglai Shen, Aviva Goel, Maria Arcila, Julie Teruya-Feldstein, Maureen F Zakowski, Stanley Frankel, Martin Peifer, Roman K Thomas, Marc Ladanyi, William Pao

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Correction: TP53 exon-6 truncating mutations produce separation of function isoforms with pro-tumorigenic functions by Nitin H Shirole, Debjani Pal, Edward R Kastenhuber, Serif Senturk, Joseph Boroda, Paola Pisterzi, Madison Miller, Gustavo Munoz, Marko Anderluh, Marc Ladanyi, Scott W Lowe, Raffaella Sordella

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DOK2 inhibits EGFR-mutated lung adenocarcinoma. by Alice H Berger, Ming Chen, Alessandro Morotti, Justyna A Janas, Masaru Niki, Roderick T Bronson, Barry S Taylor, Marc Ladanyi, Linda Van Aelst, Katerina Politi, Harold E Varmus, Pier Paolo Pandolfi

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MEK inhibitor resistance in lung adenocarcinoma is associated with addiction to sustained ERK suppression by Dylan A. Farnsworth, Yusuke Inoue, Fraser D. Johnson, Georgia de Rappard-Yuswack, Daniel Lu, Rocky Shi, Lok In Josephine Ma, Marissa S. Mattar, Romel Somwar, Marc Ladanyi, Arun M. Unni, William W. Lockwood

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NTRK kinase domain mutations in cancer variably impact sensitivity to type I and type II inhibitors by Romel Somwar, Nicolle E. Hofmann, Bryan Smith, Igor Odintsov, Morana Vojnic, Irina Linkov, Ashley Tam, Inna Khodos, Marissa S. Mattar, Elisa de Stanchina, Daniel Flynn, Marc Ladanyi, Alexander Drilon, Ujwal Shinde, Monika A. Davare

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Salt-Inducible Kinase 1 is a potential therapeutic target in Desmoplastic Small Round Cell Tumor by Alifiani Bonita Hartono, Hong-Jun Kang, Lawrence Shi, Whitney Phipps, Nathan Ungerleider, Alexandra Giardina, WeiPing Chen, Lee Spraggon, Romel Somwar, Krzysztof Moroz, David H. Drewry, Matthew E. Burow, Erik Flemington, Marc Ladanyi, Sean Bong Lee

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Comprehensive detection of germline variants by MSK-IMPACT, a clinical diagnostic platform for solid tumor molecular oncology and concurrent cancer predisposition testing by Donavan T. Cheng, Meera Prasad, Yvonne Chekaluk, Ryma Benayed, Justyna Sadowska, Ahmet Zehir, Aijazuddin Syed, Yan Elsa Wang, Joshua Somar, Yirong Li, Zarina Yelskaya, Donna Wong, Mark E. Robson, Kenneth Offit, Michael F. Berger, Khedoudja Nafa, Marc Ladanyi, Liying Zhang

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Genomic and transcriptomic analysis of a diffuse pleural mesothelioma patient-derived xenograft library by Michael Offin, Jennifer L. Sauter, Sam E. Tischfield, Jacklynn V. Egger, Shweta Chavan, Nisargbhai S. Shah, Parvathy Manoj, Katia Ventura, Viola Allaj, Elisa de Stanchina, William Travis, Marc Ladanyi, Andreas Rimner, Valerie W. Rusch, Prasad S. Adusumilli, John T. Poirier, Marjorie G. Zauderer, Charles M. Rudin, Triparna Sen

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Structure–function analysis of oncogenic EGFR Kinase Domain Duplication reveals insights into activation and a potential approach for therapeutic targeting by Zhenfang Du, Benjamin P. Brown, Soyeon Kim, Donna Ferguson, Dean C. Pavlick, Gowtham Jayakumaran, Ryma Benayed, Jean-Nicolas Gallant, Yun-Kai Zhang, Yingjun Yan, Monica Red-Brewer, Siraj M. Ali, Alexa B. Schrock, Ahmet Zehir, Marc Ladanyi, Adam W. Smith, Jens Meiler, Christine M. Lovly

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RET inhibition in novel patient-derived models of RET fusion- positive lung adenocarcinoma reveals a role for MYC upregulation by Takuo Hayashi, Igor Odintsov, Roger S. Smith, Kota Ishizawa, Allan J. W. Liu, Lukas Delasos, Christopher Kurzatkowski, Huichun Tai, Eric Gladstone, Morana Vojnic, Shinji Kohsaka, Ken Suzawa, Zebing Liu, Siddharth Kunte, Marissa S. Mattar, Inna Khodos, Monika A. Davare, Alexander Drilon, Emily Cheng, Elisa de Stanchina, Marc Ladanyi, Romel Somwar

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