Editorial: Molecular modulators of GPCRs signal transduction by Milka Vrecl, Marialessandra Contino, Marcello Leopoldo

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Editorial: Macromolecular interactions in signaling pathways: from classical approaches to virtual reality by Marcello Leopoldo, Marialessandra Contino, Stuart Maudsley, Milka Vrecl

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5-HT7 Receptors Regulate Excitatory-Inhibitory Balance in Mouse Spinal Cord Dorsal Horn by Antonella Comitato, Enza Lacivita, Marcello Leopoldo, Rita Bardoni

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Prior Activation of 5-HT7 Receptors Modulates the Conditioned Place Preference With Methylphenidate by Cristiana Carbone, Sara Lucia Maria Lo Russo, Enza Lacivita, Annika Frank, Enrico Alleva, Holger Stark, Luciano Saso, Marcello Leopoldo, Marcello Leopoldo, Walter Adriani

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Multi-Target Directed Ligands (MTDLs) Binding the σ₁ Receptor as Promising Therapeutics: State of the Art and Perspectives by Francesca Serena Abatematteo, Mauro Niso, Marialessandra Contino, Marcello Leopoldo, Carmen Abate

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THE PROTECTIVE PROPERTIES OF NEW AGONISTS OF FPR2 ON THE EVOKED BY BACTERIAL ENDOTOXIN CHANGES: IN VITRO STUDY IN GLIAL CELLS by Agnieszka Basta-Kaim, Monika Leśkiewicz, Magdalena Regulska, Ewa Trojan, Enza Lacivita, Marcello Leopoldo

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Low Basicity as a Characteristic for Atypical Ligands of Serotonin Receptor 5-HT2 by Sabina Podlewska, Ryszard Bugno, Enza Lacivita, Marcello Leopoldo, Andrzej J. Bojarski, Jadwiga Handzlik

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The brain-penetrant 5-HT7 receptor agonist LP-211 reduces the sensory and affective components of neuropathic pain by Mirko Santello, Alberto Bisco, Natalie Elisabeth Nevian, Enza Lacivita, Marcello Leopoldo, Thomas Nevian

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Microglia Depletion Attenuates the Pro-Resolving Activity of the Formyl Peptide Receptor 2 Agonist AMS21 Related to Inhibition of Inflammasome NLRP3 Signalling Pathway: A Study of... by Kinga Tylek, Ewa Trojan, Monika Leśkiewicz, Imane Ghafir El Idrissi, Enza Lacivita, Marcello Leopoldo, Agnieszka Basta-Kaim

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Behavioral, Anti-Inflammatory, and Neuroprotective Effects of a Novel FPR2 Agonist in Two Mouse Models of Autism by Claudia Cristiano, Floriana Volpicelli, Marianna Crispino, Enza Lacivita, Roberto Russo, Marcello Leopoldo, Antonio Calignano, Carla Perrone-Capano

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AM-37 and ST-36 Are Small Molecule Bombesin Receptor Antagonists by Terry W. Moody, Nicole Tashakkori, Samuel A. Mantey, Paola Moreno, Irene Ramos-Alvarez, Marcello Leopoldo, Robert T. Jensen

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The N-Formyl Peptide Receptor 2 (FPR2) Agonist MR-39 Exhibits Anti-Inflammatory Activity in LPS-Stimulated Organotypic Hippocampal Cultures by Ewa Trojan, Kinga Tylek, Monika Leśkiewicz, Władysław Lasoń, Lars-Ove Brandenburg, Marcello Leopoldo, Enza Lacivita, Agnieszka Basta-Kaim

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Selective 5-HT7 receptor agonists LP 44 and LP 211 elicit an analgesic effect on formalin-induced orofacial pain in mice by Kadriye DEMİRKAYA, Özlem Martı AKGÜN, Buğra ŞENEL, Zeynep ÖNCEL TORUN, Melik SEYREK, Enza LACİVİTA, Marcello LEOPOLDO, Ahmet DOĞRUL

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Design and Synthesis of Arylpiperazine Serotonergic/Dopaminergic Ligands with Neuroprotective Properties by Margherita Mastromarino, Mauro Niso, Carmen Abate, Ewgenij Proschak, Mariam Dubiel, Holger Stark, Marián Castro, Enza Lacivita, Marcello Leopoldo

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Time-Dependent Protective and Pro-Resolving Effects of FPR2 Agonists on Lipopolysaccharide-Exposed Microglia Cells Involve Inhibition of NF-κB and MAPKs Pathways by Kinga Tylek, Ewa Trojan, Monika Leśkiewicz, Magdalena Regulska, Natalia Bryniarska, Katarzyna Curzytek, Enza Lacivita, Marcello Leopoldo, Agnieszka Basta-Kaim

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LC–MS/MS Analysis on Infusion Bags and Filled Syringes of Decitabine: New Data on Physicochemical Stability of an Unstable Molecule by Mariarita Laforgia, Loredana Amodio, Santina Colangiulo, Valentina Ungaro, Letizia Gatti, Gianpiero Lucarelli, Marcello Leopoldo, Patrizia Nardulli, Nicola A. Colabufo

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Evaluating the effect of R-Baclofen and LP-211 on autistic behavior of the BTBR and Fmr1-KO mouse models by Shirin Sharghi, Shirin Sharghi, Stefanie Flunkert, Magdalena Daurer, Roland Rabl, Boris Philippe Chagnaud, Marcello Leopoldo, Enza Lacivita, Birgit Hutter-Paier, Manuela Prokesch

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Mitochondrial Membranes of Human SH-SY5Y Neuroblastoma Cells Express Serotonin 5-HT₇ Receptor by Alessandra Tempio, Mauro Niso, Luna Laera, Lucia Trisolini, Maria Favia, Lucia Ciranna, Domenico Marzulli, Giuseppe Petrosillo, Ciro Leonardo Pierri, Enza Lacivita, Marcello Leopoldo

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A conformational rearrangement of the SARS-CoV-2 host protein sigma-1 is required for antiviral activity: insights from a combined in-silico/in-vitro approach by Francesca Serena Abatematteo, Pietro Delre, Ivan Mercurio, Veronica V. Rezelj, Dritan Siliqi, Stephanie Beaucourt, Gianluca Lattanzi, Nicola Antonio Colabufo, Marcello Leopoldo, Michele Saviano, Marco Vignuzzi, Giuseppe Felice Mangiatordi, Carmen Abate

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