Desmoplastic Reaction, Immune Cell Response, and Prognosis in Colorectal Cancer by Naohiko Akimoto, Naohiko Akimoto, Juha P. Väyrynen, Juha P. Väyrynen, Juha P. Väyrynen, Melissa Zhao, Tomotaka Ugai, Tomotaka Ugai, Kenji Fujiyoshi, Jennifer Borowsky, Rong Zhong, Koichiro Haruki, Kota Arima, Mai Chan Lau, Junko Kishikawa, Tyler S. Twombly, Yasutoshi Takashima, Mingyang Song, Mingyang Song, Mingyang Song, Xuehong Zhang, Xuehong Zhang, Kana Wu, Kana Wu, Kana Wu, Andrew T. Chan, Andrew T. Chan, Andrew T. Chan, Andrew T. Chan, Jeffrey A. Meyerhardt, Marios Giannakis, Marios Giannakis, Marios Giannakis, Jonathan A. Nowak, Shuji Ogino, Shuji Ogino, Shuji Ogino, Shuji Ogino

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Identifying regulators of aberrant stem cell and differentiation activity in colorectal cancer using a dual endogenous reporter system by Sandor Spisak, David Chen, Pornlada Likasitwatanakul, Paul Doan, Zhixin Li, Pratyusha Bala, Laura Vizkeleti, Viktoria Tisza, Pushpamali De Silva, Marios Giannakis, Brian Wolpin, Jun Qi, Nilay S. Sethi

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Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy by Veronica Rendo, Ivaylo Stoimenov, André Mateus, Elin Sjöberg, Richard Svensson, Anna-Lena Gustavsson, Lars Johansson, Adrian Ng, Casey OʼBrien, Marios Giannakis, Per Artursson, Peter Nygren, Ian Cheong, Tobias Sjöblom

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RNF43 G659fs is an oncogenic colorectal cancer mutation and sensitizes tumor cells to PI3K/mTOR inhibition by Lishan Fang, Dane Ford-Roshon, Max Russo, Casey O’Brien, Xiaozhe Xiong, Carino Gurjao, Maximilien Grandclaudon, Srivatsan Raghavan, Steven M. Corsello, Steven A. Carr, Namrata D. Udeshi, James Berstler, Ewa Sicinska, Kimmie Ng, Marios Giannakis

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Healthy and unhealthy plant‐based diets in relation to the incidence of colorectal cancer overall and by molecular subtypes by Fenglei Wang, Tomotaka Ugai, Koichiro Haruki, Yi Wan, Naohiko Akimoto, Kota Arima, Rong Zhong, Tyler S. Twombly, Kana Wu, Kanhua Yin, Andrew T. Chan, Marios Giannakis, Jonathan A. Nowak, Jeffrey A. Meyerhardt, Liming Liang, Mingyang Song, Stephanie A. Smith‐Warner, Xuehong Zhang, Edward L. Giovannucci, Walter C. Willett, Shuji Ogino

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Tumor Long Interspersed Nucleotide Element-1 (LINE-1) Hypomethylation in Relation to Age of Colorectal Cancer Diagnosis and Prognosis by Naohiko Akimoto, Melissa Zhao, Tomotaka Ugai, Rong Zhong, Mai Chan Lau, Kenji Fujiyoshi, Junko Kishikawa, Koichiro Haruki, Kota Arima, Tyler S. Twombly, Xuehong Zhang, Edward L. Giovannucci, Kana Wu, Mingyang Song, Andrew T. Chan, Yin Cao, Jeffrey A. Meyerhardt, Kimmie Ng, Marios Giannakis, Juha P. Väyrynen, Jonathan A. Nowak, Shuji Ogino

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Inverse relationship between Fusobacterium nucleatum amount and tumor CD274 (PD‐L1) expression in colorectal carcinoma by Tomotaka Ugai, Takashi Shimizu, Hidetaka Kawamura, Satoko Ugai, Yasutoshi Takashima, Genki Usui, Juha P Väyrynen, Kazuo Okadome, Koichiro Haruki, Naohiko Akimoto, Yohei Masugi, Annacarolina daSilva, Kosuke Mima, Xuehong Zhang, Andrew T Chan, Molin Wang, Wendy S Garrett, Gordon J Freeman, Jeffrey A Meyerhardt, Jonathan A Nowak, Mingyang Song, Marios Giannakis, Shuji Ogino

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Association of PIK3CA mutation and PTEN loss with expression of CD274 (PD-L1) in colorectal carcinoma by Tomotaka Ugai, Melissa Zhao, Takashi Shimizu, Naohiko Akimoto, Shanshan Shi, Yasutoshi Takashima, Rong Zhong, Mai Chan Lau, Koichiro Haruki, Kota Arima, Kenji Fujiyoshi, Benjamin Langworthy, Yohei Masugi, Annacarolina da Silva, Katsuhiko Nosho, Yoshifumi Baba, Mingyang Song, Andrew T. Chan, Molin Wang, Jeffrey A. Meyerhardt, Marios Giannakis, Juha P. Väyrynen, Jonathan A. Nowak, Shuji Ogino

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Histopathology images predict multi-omics aberrations and prognoses in colorectal cancer patients by Pei-Chen Tsai, Tsung-Hua Lee, Kun-Chi Kuo, Fang-Yi Su, Tsung-Lu Michael Lee, Eliana Marostica, Tomotaka Ugai, Melissa Zhao, Mai Chan Lau, Juha P. Väyrynen, Marios Giannakis, Yasutoshi Takashima, Seyed Mousavi Kahaki, Kana Wu, Mingyang Song, Jeffrey A. Meyerhardt, Andrew T. Chan, Jung-Hsien Chiang, Jonathan Nowak, Shuji Ogino, Kun-Hsing Yu

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Bayesian risk prediction model for colorectal cancer mortality through integration of clinicopathologic and genomic data by Melissa Zhao, Mai Chan Lau, Koichiro Haruki, Juha P. Väyrynen, Carino Gurjao, Sara A. Väyrynen, Andressa Dias Costa, Jennifer Borowsky, Kenji Fujiyoshi, Kota Arima, Tsuyoshi Hamada, Jochen K. Lennerz, Charles S. Fuchs, Reiko Nishihara, Andrew T. Chan, Kimmie Ng, Xuehong Zhang, Jeffrey A. Meyerhardt, Mingyang Song, Molin Wang, Marios Giannakis, Jonathan A. Nowak, Kun-Hsing Yu, Tomotaka Ugai, Shuji Ogino

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Metabolomic adaptations and correlates of survival to immune checkpoint blockade by Haoxin Li, Kevin Bullock, Carino Gurjao, David Braun, Sachet A. Shukla, Dominick Bossé, Aly-Khan A. Lalani, Shuba Gopal, Chelsea Jin, Christine Horak, Megan Wind-Rotolo, Sabina Signoretti, David F. McDermott, Gordon J. Freeman, Eliezer M. Van Allen, Stuart L. Schreiber, F. Stephen Hodi, William R. Sellers, Levi A. Garraway, Clary B. Clish, Toni K. Choueiri, Marios Giannakis

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Tumour budding, poorly differentiated clusters, and T-cell response in colorectal cancer by Kenji Fujiyoshi, Juha P. Väyrynen, Jennifer Borowsky, David J. Papke, Jr., Kota Arima, Koichiro Haruki, Junko Kishikawa, Naohiko Akimoto, Tomotaka Ugai, Mai Chan Lau, Simeng Gu, Shanshan Shi, Melissa Zhao, Annacarolina Fabiana Lucia Da Silva, Tyler S. Twombly, Hongmei Nan, Jeffrey A. Meyerhardt, Mingyang Song, Xuehong Zhang, Kana Wu, Andrew T. Chan, Charles S. Fuchs, Jochen K. Lennerz, Marios Giannakis, Jonathan A. Nowak, Shuji Ogino

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Prognostic role of inflammatory diets in colorectal cancer overall and in strata of tumor‐infiltrating lymphocyte levels by Tomotaka Ugai, Li Liu, Fred K. Tabung, Tsuyoshi Hamada, Benjamin W. Langworthy, Naohiko Akimoto, Koichiro Haruki, Yasutoshi Takashima, Kazuo Okadome, Hidetaka Kawamura, Melissa Zhao, Seyed Mostafa Mousavi Kahaki, Jonathan N. Glickman, Jochen K. Lennerz, Xuehong Zhang, Andrew T. Chan, Charles S. Fuchs, Mingyang Song, Molin Wang, Kun‐Hsing Yu, Marios Giannakis, Jonathan A. Nowak, Jeffrey A. Meyerhardt, Kana Wu, Shuji Ogino, Edward L. Giovannucci

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Association between germline variants and somatic mutations in colorectal cancer by Richard Barfield, Conghui Qu, Robert S. Steinfelder, Chenjie Zeng, Tabitha A. Harrison, Stefanie Brezina, Daniel D. Buchanan, Peter T. Campbell, Graham Casey, Steven Gallinger, Marios Giannakis, Stephen B. Gruber, Andrea Gsur, Li Hsu, Jeroen R. Huyghe, Victor Moreno, Polly A. Newcomb, Shuji Ogino, Amanda I. Phipps, Martha L. Slattery, Stephen N. Thibodeau, Quang M. Trinh, Amanda E. Toland, Thomas J. Hudson, Wei Sun, Syed H. Zaidi, Ulrike Peters

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TIME (Tumor Immunity in the MicroEnvironment) classification based on tumor CD274 (PD-L1) expression status and tumor-infiltrating lymphocytes in colorectal carcinomas by Tsuyoshi Hamada, Thing Rinda Soong, Yohei Masugi, Keisuke Kosumi, Jonathan A. Nowak, Annacarolina da Silva, Xinmeng Jasmine Mu, Tyler S. Twombly, Hideo Koh, Juhong Yang, Mingyang Song, Li Liu, Mancang Gu, Yan Shi, Katsuhiko Nosho, Teppei Morikawa, Kentaro Inamura, Sachet A. Shukla, Catherine J. Wu, Levi A. Garraway, Xuehong Zhang, Kana Wu, Jeffrey A. Meyerhardt, Andrew T. Chan, Jonathan N. Glickman, Scott J. Rodig, Gordon J. Freeman, Charles S. Fuchs, Reiko Nishihara, Marios Giannakis, Shuji Ogino

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Genomic Correlates of Immune-Cell Infiltrates in Colorectal Carcinoma by Marios Giannakis, Xinmeng Jasmine Mu, Sachet A. Shukla, Zhi Rong Qian, Ofir Cohen, Reiko Nishihara, Samira Bahl, Yin Cao, Ali Amin-Mansour, Mai Yamauchi, Yasutaka Sukawa, Chip Stewart, Mara Rosenberg, Kosuke Mima, Kentaro Inamura, Katsuhiko Nosho, Jonathan A. Nowak, Michael S. Lawrence, Edward L. Giovannucci, Andrew T. Chan, Kimmie Ng, Jeffrey A. Meyerhardt, Eliezer M. Van Allen, Gad Getz, Stacey B. Gabriel, Eric S. Lander, Catherine J. Wu, Charles S. Fuchs, Shuji Ogino, Levi A. Garraway

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Identifying colorectal cancer caused by biallelic MUTYH pathogenic variants using tumor mutational signatures by Peter Georgeson, Tabitha A. Harrison, Bernard J. Pope, Syed H. Zaidi, Conghui Qu, Robert S. Steinfelder, Yi Lin, Jihoon E. Joo, Khalid Mahmood, Mark Clendenning, Romy Walker, Efrat L. Amitay, Sonja I. Berndt, Hermann Brenner, Peter T. Campbell, Yin Cao, Andrew T. Chan, Jenny Chang-Claude, Kimberly F. Doheny, David A. Drew, Jane C. Figueiredo, Amy J. French, Steven Gallinger, Marios Giannakis, Graham G. Giles, Andrea Gsur, Marc J. Gunter, Michael Hoffmeister, Li Hsu, Wen-Yi Huang, Paul Limburg, JoAnn E. Manson, Victor Moreno, Rami Nassir, Jonathan A. Nowak, Mireia Obón-Santacana, Shuji Ogino, Amanda I. Phipps, John D. Potter, Robert E. Schoen, Wei Sun, Amanda E. Toland, Quang M. Trinh, Tomotaka Ugai, Finlay A. Macrae, Christophe Rosty, Thomas J. Hudson, Mark A. Jenkins, Stephen N. Thibodeau, Ingrid M. Winship, Ulrike Peters, Daniel D. Buchanan

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Body size and risk of colorectal cancer molecular defined subtypes and pathways: Mendelian randomization analysesResearch in context by Nikos Papadimitriou, Conghui Qu, Tabitha A. Harrison, Alaina M. Bever, Richard M. Martin, Konstantinos K. Tsilidis, Polly A. Newcomb, Stephen N. Thibodeau, Christina C. Newton, Caroline Y. Um, Mireia Obón-Santacana, Victor Moreno, Hermann Brenner, Marko Mandic, Jenny Chang-Claude, Michael Hoffmeister, Andrew J. Pellatt, Robert E. Schoen, Sophia Harlid, Shuji Ogino, Tomotaka Ugai, Daniel D. Buchanan, Brigid M. Lynch, Stephen B. Gruber, Yin Cao, Li Hsu, Jeroen R. Huyghe, Yi Lin, Robert S. Steinfelder, Wei Sun, Bethany Van Guelpen, Syed H. Zaidi, Amanda E. Toland, Sonja I. Berndt, Wen-Yi Huang, Elom K. Aglago, David A. Drew, Amy J. French, Peter Georgeson, Marios Giannakis, Meredith Hullar, Johnathan A. Nowak, Claire E. Thomas, Loic Le Marchand, Iona Cheng, Steven Gallinger, Mark A. Jenkins, Marc J. Gunter, Peter T. Campbell, Ulrike Peters, Mingyang Song, Amanda I. Phipps, Neil Murphy

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