Implications of HIV-1 Nef for “Shock and Kill” Strategies to Eliminate Latent Viral Reservoirs by Xiaomei T. Kuang, Mark A. Brockman

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Human Leukocyte Antigen (HLA) Class I Down-Regulation by Human Immunodeficiency Virus Type 1 Negative Factor (HIV-1 Nef): What Might We Learn From Natural Sequence Variants? by Philip Mwimanzi, Tristan J. Markle, Mark A. Brockman, Takamasa Ueno

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19 HIV-1 Nef enhances viral reactivation and downregulates HLA class I: a dual role in modulating immune-mediated clearance of reservoirs by XiaomeiT Kuang, Steven Jin, TristanM Markle, MarkA Brockman

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Diagnostic Accuracy of the HemoCue Hb 301, STAT-Site MHgb and URIT-12 Point-of-Care Hemoglobin Meters in a Central Laboratory and a Community Based Clinic in Durban, South Africa. by Manjeetha Jaggernath, Rumallen Naicker, Savathree Madurai, Mark A Brockman, Thumbi Ndung'u, Huub C Gelderblom

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Attenuated HIV-1 Nef But Not Vpu Function in a Cohort of Rwandan Long-Term Survivors by Gisele Umviligihozo, Jaclyn K. Mann, Steven W. Jin, Francis M. Mwimanzi, Hua-Shiuan A. Hsieh, Hanwei Sudderuddin, Guinevere Q. Lee, Helen Byakwaga, Helen Byakwaga, Conrad Muzoora, Peter W. Hunt, Jeff N. Martin, Jessica E. Haberer, Jessica E. Haberer, Etienne Karita, Susan Allen, Eric Hunter, Eric Hunter, Zabrina L. Brumme, Zabrina L. Brumme, Mark A. Brockman, Mark A. Brockman, Mark A. Brockman

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No detectable differences in Nef-mediated downregulation of HLA-I and CD4 molecules among HIV-1 group M lineages circulating in Cameroon, where the pandemic originated by Nelson Sonela, Nelson Sonela, Nelson Sonela, Jaclyn Mann, Celestin Godwe, Celestin Godwe, Oumarou H. Goni, Oumarou H. Goni, Mérime Tchakoute, Nathalie Nkoue, Tulio de Oliveira, Tulio de Oliveira, Mark A. Brockman, Mark A. Brockman, Mark A. Brockman, Zabrina L. Brumme, Zabrina L. Brumme, Thumbi Ndung’u, Thumbi Ndung’u, Thumbi Ndung’u, Thumbi Ndung’u, Thumbi Ndung’u, Marcel Tongo

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Quantitative effect of suboptimal codon usage on translational efficiency of mRNA encoding HIV-1 gag in intact T cells. by Kholiswa C Ngumbela, Kieran P Ryan, Rohini Sivamurthy, Mark A Brockman, Rajesh T Gandhi, Nina Bhardwaj, Daniel G Kavanagh

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Identification of Novel HIV-1 Latency-Reversing Agents from a Library of Marine Natural Products by Khumoekae Richard, David E. Williams, E. Dilip de Silva, Mark A. Brockman, Zabrina L. Brumme, Raymond J. Andersen, Ian Tietjen

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Relative Resistance of HLA-B to Downregulation by Naturally Occurring HIV-1 Nef Sequences by Macdonald Mahiti, Mako Toyoda, Xiaofei Jia, Xiaomei T. Kuang, Francis Mwimanzi, Philip Mwimanzi, Bruce D. Walker, Yong Xiong, Zabrina L. Brumme, Mark A. Brockman, Takamasa Ueno

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HIV-1 subtype C Nef-mediated SERINC5 down-regulation significantly contributes to overall Nef activity by Delon Naicker, Nelson Sonela, Steven W. Jin, Takalani Mulaudzi, Doty Ojwach, Tarylee Reddy, Mark A. Brockman, Zabrina L. Brumme, Thumbi Ndung’u, Jaclyn K. Mann

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African-led health research and capacity building- is it working? by Victoria O. Kasprowicz, Denis Chopera, Kim Darley Waddilove, Mark A. Brockman, Jill Gilmour, Eric Hunter, William Kilembe, Etienne Karita, Simani Gaseitsiwe, Eduard J. Sanders, Thumbi Ndung’u

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Natural HIV-1 Nef Polymorphisms Impair SERINC5 Downregulation Activity by Steven W. Jin, Nirmin Alsahafi, Xiaomei T. Kuang, Shayda A. Swann, Mako Toyoda, Heinrich Göttlinger, Bruce D. Walker, Takamasa Ueno, Andrés Finzi, Zabrina L. Brumme, Mark A. Brockman

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Dual HLA B*42 and B*81-reactive T cell receptors recognize more diverse HIV-1 Gag escape variants by Funsho Ogunshola, Gursev Anmole, Rachel L. Miller, Emily Goering, Thandeka Nkosi, Daniel Muema, Jaclyn Mann, Nasreen Ismail, Denis Chopera, Thumbi Ndung’u, Mark A. Brockman, Zaza M Ndhlovu

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Serial infection with SARS-CoV-2 Omicron BA.1 and BA.2 following three-dose COVID-19 vaccination by Hope R. Lapointe, Francis Mwimanzi, Peter K. Cheung, Peter K. Cheung, Yurou Sang, Fatima Yaseen, Rebecca Kalikawe, Sneha Datwani, Rachel Waterworth, Gisele Umviligihozo, Siobhan Ennis, Landon Young, Winnie Dong, Don Kirkby, Laura Burns, Victor Leung, Victor Leung, Victor Leung, Daniel T. Holmes, Daniel T. Holmes, Mari L. DeMarco, Mari L. DeMarco, Janet Simons, Janet Simons, Nancy Matic, Nancy Matic, Nancy Matic, Julio S.G. Montaner, Julio S.G. Montaner, Chanson J. Brumme, Chanson J. Brumme, Natalie Prystajecky, Natalie Prystajecky, Masahiro Niikura, Christopher F. Lowe, Christopher F. Lowe, Christopher F. Lowe, Marc G. Romney, Marc G. Romney, Marc G. Romney, Mark A. Brockman, Mark A. Brockman, Mark A. Brockman, Zabrina L. Brumme, Zabrina L. Brumme

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Variation in HIV-1 Nef function within and among viral subtypes reveals genetically separable antagonism of SERINC3 and SERINC5. by Steven W Jin, Francis M Mwimanzi, Jaclyn K Mann, Mwebesa Bosco Bwana, Guinevere Q Lee, Chanson J Brumme, Peter W Hunt, Jeff N Martin, David R Bangsberg, Thumbi Ndung'u, Zabrina L Brumme, Mark A Brockman

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Screening of the Pan-African natural product library identifies ixoratannin A-2 and boldine as novel HIV-1 inhibitors. by Ian Tietjen, Fidele Ntie-Kang, Philip Mwimanzi, Pascal Amoa Onguéné, Margaret A Scull, Thomas Oyebode Idowu, Abiodun Oguntuga Ogundaini, Luc Mbaze Meva'a, Berhanu M Abegaz, Charles M Rice, Kerstin Andrae-Marobela, Mark A Brockman, Zabrina L Brumme, David Fedida

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HIV Proviral Burden, Genetic Diversity, and Dynamics in Viremic Controllers Who Subsequently Initiated Suppressive Antiretroviral Therapy by F. Harrison Omondi, Hanwei Sudderuddin, Aniqa Shahid, Natalie N. Kinloch, Bradley R. Jones, Rachel L. Miller, Olivia Tsai, Daniel MacMillan, Alicja Trocha, Mark A. Brockman, Chanson J. Brumme, Jeffrey B. Joy, Richard Liang, Bruce D. Walker, Zabrina L. Brumme

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HIV reservoirs are dominated by genetically younger and clonally enriched proviruses by Natalie N. Kinloch, Aniqa Shahid, Winnie Dong, Don Kirkby, Bradley R. Jones, Charlotte J. Beelen, Daniel MacMillan, Guinevere Q. Lee, Talia M. Mota, Hanwei Sudderuddin, Evan Barad, Marianne Harris, Chanson J. Brumme, R. Brad Jones, Mark A. Brockman, Jeffrey B. Joy, Zabrina L. Brumme

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The Thiazole-5-Carboxamide GPS491 Inhibits HIV-1, Adenovirus, and Coronavirus Replication by Altering RNA Processing/Accumulation by Subha Dahal, Ran Cheng, Peter K. Cheung, Terek Been, Ramy Malty, Melissa Geng, Sarah Manianis, Lulzim Shkreta, Shahrazad Jahanshahi, Johanne Toutant, Rose Chan, Sean Park, Mark A. Brockman, Mohan Babu, Samira Mubareka, Karen Mossman, Arinjay Banerjee, Scott Gray-Owen, Martha Brown, Walid A. Houry, Benoit Chabot, David Grierson, Alan Cochrane

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Progression to AIDS in South Africa is associated with both reverting and compensatory viral mutations. by Kuan-Hsiang Gary Huang, Dominique Goedhals, Jonathan M Carlson, Mark A Brockman, Swati Mishra, Zabrina L Brumme, Stephen Hickling, Christopher S W Tang, Toshiyuki Miura, Chris Seebregts, David Heckerman, Thumbi Ndung'u, Bruce Walker, Paul Klenerman, Dewald Steyn, Philip Goulder, Rodney Phillips, Bloemfontein-Oxford Collaborative Group, Cloete van Vuuren, John Frater

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