Mark Daly (scientist)

Mark Joseph Daly is Director of the Finnish Institute for Molecular Medicine (FIMM) at the University of Helsinki, a Professor of Genetics at Harvard Medical School, Chief of the Analytic and Translational Genetic Unit at Massachusetts General Hospital, and a member of the Broad Institute of MIT and Harvard. In the early days of the Human Genome Project, Daly helped develop the genetic model by which linkage disequilibrium could be used to map the haplotype structure of the human genome. In addition, he developed statistical methods to find associations between genes and disorders such as Crohn's disease, inflammatory bowel disease, autism and schizophrenia.

Daly is considered a pioneer in the field of human genetics, and is amongst the most cited scientists in the field, and one of the top 100 most cited scientists of all time. He was elected to the National Academy of Medicine in 2017. Provided by Wikipedia
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  1. 1
    Mosaic mutations in blood DNA sequence are associated with solid tumor cancers

    Mosaic mutations in blood DNA sequence are associated with solid tumor cancers by Mykyta Artomov, Manuel A. Rivas, Giulio Genovese, Mark J. Daly

    Published 2017-07-01
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  2. 2
    Network Analysis of Genome-Wide Selective Constraint Reveals a Gene Network Active in Early Fetal Brain Intolerant of Mutation.

    Network Analysis of Genome-Wide Selective Constraint Reveals a Gene Network Active in Early Fetal Brain Intolerant of Mutation. by Jinmyung Choi, Parisa Shooshtari, Kaitlin E Samocha, Mark J Daly, Chris Cotsapas

    Published 2016-06-01
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  3. 3
    Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant.

    Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant. by Petric Kuballa, Alan Huett, John D Rioux, Mark J Daly, Ramnik J Xavier

    Published 2008-01-01
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  4. 4
    Genetic variants in cellular transport do not affect mesalamine response in ulcerative colitis.

    Genetic variants in cellular transport do not affect mesalamine response in ulcerative colitis. by Christopher J Moran, Hailiang Huang, Manuel Rivas, Jess L Kaplan, Mark J Daly, Harland S Winter

    Published 2018-01-01
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  5. 5
    Mendelian Randomization Analysis reveals Inverse Genetic Risks between Skin Cancers and Vitiligo

    Mendelian Randomization Analysis reveals Inverse Genetic Risks between Skin Cancers and Vitiligo by Sarem Rashid, Ivan Molotkov, Nikolai Klebanov, Michael Shaughnessy, Mark J. Daly, Mykyta Artomov, Hensin Tsao

    Published 2023-11-01
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  6. 6
    Common inherited variation in mitochondrial genes is not enriched for associations with type 2 diabetes or related glycemic traits.

    Common inherited variation in mitochondrial genes is not enriched for associations with type 2 diabetes or related glycemic traits. by Ayellet V Segrè, DIAGRAM Consortium, MAGIC investigators, Leif Groop, Vamsi K Mootha, Mark J Daly, David Altshuler

    Published 2010-08-01
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  7. 7
    Profiling the inflammatory bowel diseases using genetics, serum biomarkers, and smoking information

    Profiling the inflammatory bowel diseases using genetics, serum biomarkers, and smoking information by Ruize Liu, Dalin Li, Talin Haritunians, Yunfeng Ruan, Mark J. Daly, Hailiang Huang, Dermot P.B. McGovern

    Published 2023-10-01
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  8. 8
    Case Report: Supernormal Vascular Aging in Leningrad Siege Survivors

    Case Report: Supernormal Vascular Aging in Leningrad Siege Survivors by Oxana Rotar, Maria Boyarinova, Ekaterina Moguchaya, Kristina Tolkunova, Nikita Kolosov, Nikita Kolosov, Nikita Kolosov, Valeriia Rezapova, Valeriia Rezapova, Valeriia Rezapova, Olga Freylikhman, Dmitrii Usoltsev, Dmitrii Usoltsev, Dmitrii Usoltsev, Olesya Melnik, Alexey Sergushichev, Vladislav Solntsev, Anna Kostareva, Elena Dubinina, Elena Dubinina, Trudy Voortman, Trudy Voortman, Christine Stevens, Mark J. Daly, Mark J. Daly, Mark J. Daly, Alexandra Konradi, Alexandra Konradi, Evgeny Shlyakhto, Mykyta Artomov, Mykyta Artomov, Mykyta Artomov, Mykyta Artomov, Mykyta Artomov

    Published 2022-05-01
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  9. 9
    Accurately assessing the risk of schizophrenia conferred by rare copy-number variation affecting genes with brain function.

    Accurately assessing the risk of schizophrenia conferred by rare copy-number variation affecting genes with brain function. by Soumya Raychaudhuri, Joshua M Korn, Steven A McCarroll, International Schizophrenia Consortium, David Altshuler, Pamela Sklar, Shaun Purcell, Mark J Daly

    Published 2010-09-01
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  10. 10
    Host genetic variation and its microbiome interactions within the Human Microbiome Project

    Host genetic variation and its microbiome interactions within the Human Microbiome Project by Raivo Kolde, Eric A. Franzosa, Gholamali Rahnavard, Andrew Brantley Hall, Hera Vlamakis, Christine Stevens, Mark J. Daly, Ramnik J. Xavier, Curtis Huttenhower

    Published 2018-01-01
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  11. 11
    Changes in the fine-scale genetic structure of Finland through the 20th century.

    Changes in the fine-scale genetic structure of Finland through the 20th century. by Sini Kerminen, Nicola Cerioli, Darius Pacauskas, Aki S Havulinna, Markus Perola, Pekka Jousilahti, Veikko Salomaa, Mark J Daly, Rupesh Vyas, Samuli Ripatti, Matti Pirinen

    Published 2021-03-01
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  12. 12
    ANGPTL8 protein-truncating variant associated with lower serum triglycerides and risk of coronary disease.

    ANGPTL8 protein-truncating variant associated with lower serum triglycerides and risk of coronary disease. by Pyry Helkkula, Tuomo Kiiskinen, Aki S Havulinna, Juha Karjalainen, Seppo Koskinen, Veikko Salomaa, Mark J Daly, Aarno Palotie, Ida Surakka, Samuli Ripatti, FinnGen

    Published 2021-04-01
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  13. 13
    Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology.

    Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology. by Elizabeth J Rossin, Kasper Lage, Soumya Raychaudhuri, Ramnik J Xavier, Diana Tatar, Yair Benita, International Inflammatory Bowel Disease Genetics Constortium, Chris Cotsapas, Mark J Daly

    Published 2011-01-01
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  14. 14
    Genotype imputation and polygenic score estimation in northwestern Russian population.

    Genotype imputation and polygenic score estimation in northwestern Russian population. by Nikita Kolosov, Valeriia Rezapova, Oxana Rotar, Alexander Loboda, Olga Freylikhman, Olesya Melnik, Alexey Sergushichev, Christine Stevens, Trudy Voortman, Anna Kostareva, Alexandra Konradi, Mark J Daly, Mykyta Artomov

    Published 2022-01-01
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  15. 15
    Medical relevance of protein-truncating variants across 337,205 individuals in the UK Biobank study

    Medical relevance of protein-truncating variants across 337,205 individuals in the UK Biobank study by Christopher DeBoever, Yosuke Tanigawa, Malene E. Lindholm, Greg McInnes, Adam Lavertu, Erik Ingelsson, Chris Chang, Euan A. Ashley, Carlos D. Bustamante, Mark J. Daly, Manuel A. Rivas

    Published 2018-04-01
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  16. 16
    Mutations in ATP13A2 (PARK9) are associated with an amyotrophic lateral sclerosis-like phenotype, implicating this locus in further phenotypic expansion

    Mutations in ATP13A2 (PARK9) are associated with an amyotrophic lateral sclerosis-like phenotype, implicating this locus in further phenotypic expansion by Rossella Spataro, Maria Kousi, Sali M. K. Farhan, Jason R. Willer, Jay P. Ross, Patrick A. Dion, Guy A. Rouleau, Mark J. Daly, Benjamin M. Neale, Vincenzo La Bella, Nicholas Katsanis

    Published 2019-04-01
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  17. 17
    Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions.

    Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions. by Soumya Raychaudhuri, Robert M Plenge, Elizabeth J Rossin, Aylwin C Y Ng, International Schizophrenia Consortium, Shaun M Purcell, Pamela Sklar, Edward M Scolnick, Ramnik J Xavier, David Altshuler, Mark J Daly

    Published 2009-06-01
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  18. 18
    SLC39A8 missense variant is associated with Crohn's disease but does not have a major impact on gut microbiome composition in healthy subjects.

    SLC39A8 missense variant is associated with Crohn's disease but does not have a major impact on gut microbiome composition in healthy subjects. by Valerie Collij, Floris Imhann, Arnau Vich Vila, Jingyuan Fu, Gerard Dijkstra, Eleonora A M Festen, Michiel D Voskuil, Mark J Daly, Ramnik J Xavier, Cisca Wijmenga, Alexandra Zhernakova, Rinse K Weersma

    Published 2019-01-01
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  19. 19
    Integrated model of de novo and inherited genetic variants yields greater power to identify risk genes.

    Integrated model of de novo and inherited genetic variants yields greater power to identify risk genes. by Xin He, Stephan J Sanders, Li Liu, Silvia De Rubeis, Elaine T Lim, James S Sutcliffe, Gerard D Schellenberg, Richard A Gibbs, Mark J Daly, Joseph D Buxbaum, Matthew W State, Bernie Devlin, Kathryn Roeder

    Published 2013-01-01
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  20. 20
    Polygenic adaptation on height is overestimated due to uncorrected stratification in genome-wide association studies

    Polygenic adaptation on height is overestimated due to uncorrected stratification in genome-wide association studies by Mashaal Sohail, Robert M Maier, Andrea Ganna, Alex Bloemendal, Alicia R Martin, Michael C Turchin, Charleston WK Chiang, Joel Hirschhorn, Mark J Daly, Nick Patterson, Benjamin Neale, Iain Mathieson, David Reich, Shamil R Sunyaev

    Published 2019-03-01
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