Molecules that cause or prevent Parkinson's disease. 由 Mark R Cookson

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Leucine-Rich Repeat Kinase 2 Mutations and Parkinson's Disease: Three Questions 由 Elisa Greggio, Mark R Cookson

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Generation of gene-corrected isogenic controls from Parkinson's disease patient iPSC lines carrying the pathogenic SNCA p.A53T variant 由 Nikita Kozhushko, Aleksandra Beilina, Mark R. Cookson

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Glial phagocytic clearance in Parkinson’s disease 由 Marie-Eve Tremblay, Mark R. Cookson, Laura Civiero

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The role of monogenic genes in idiopathic Parkinson’s disease 由 Xylena Reed, Sara Bandrés-Ciga, Cornelis Blauwendraat, Mark R. Cookson

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Generation of fourteen isogenic cell lines for Parkinson’s disease-associated leucine-rich repeat kinase (LRRK2) 由 Aleksandra Beylina, Rebekah G. Langston, Dorien Rosen, Xylena Reed, Mark R. Cookson

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Directing LRRK2 to membranes of the endolysosomal pathway triggers RAB phosphorylation and JIP4 recruitment 由 Jillian H. Kluss, Luis Bonet-Ponce, Patrick A. Lewis, Mark R. Cookson

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Generation of iPSC line from a Parkinson patient with PARK7 mutation and CRISPR-edited Gibco human episomal iPSC line to mimic PARK7 mutation 由 Melissa Conti Mazza, Alexandra Beilina, Dorien A. Roosen, David Hauser, Mark R. Cookson

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Post-translational decrease in respiratory chain proteins in the Polg mutator mouse brain. 由 David N Hauser, Allissa A Dillman, Jinhui Ding, Yan Li, Mark R Cookson

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Preclinical modeling of chronic inhibition of the Parkinson’s disease associated kinase LRRK2 reveals altered function of the endolysosomal system in vivo 由 Jillian H. Kluss, Melissa Conti Mazza, Yan Li, Claudia Manzoni, Patrick A. Lewis, Mark R. Cookson, Adamantios Mamais

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Structure and regulation of full-length human leucine-rich repeat kinase 1 由 Riley D. Metcalfe, Juliana A. Martinez Fiesco, Luis Bonet-Ponce, Jillian H. Kluss, Mark R. Cookson, Ping Zhang

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Transcriptional signatures in iPSC-derived neurons are reproducible across labs when differentiation protocols are closely matched 由 Xylena Reed, Melanie M. Cobb, Gaia Skinbinski, Dorien Roosen, Alice Kaganovich, Jinhui Ding, Steve Finkbeiner, Mark R. Cookson

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The Parkinson's disease associated LRRK2 exhibits weaker in vitro phosphorylation of 4E-BP compared to autophosphorylation. 由 Azad Kumar, Elisa Greggio, Alexandra Beilina, Alice Kaganovich, Diane Chan, Jean-Marc Taymans, Benjamin Wolozin, Mark R Cookson

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LRRK2 kinase activity is dependent on LRRK2 GTP binding capacity but independent of LRRK2 GTP binding. 由 Jean-Marc Taymans, Renée Vancraenenbroeck, Petri Ollikainen, Alexandra Beilina, Evy Lobbestael, Marc De Maeyer, Veerle Baekelandt, Mark R Cookson

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Variant biomarker discovery using mass spectrometry-based proteogenomics 由 Luke Reilly, Sahba Seddighi, Andrew B. Singleton, Andrew B. Singleton, Mark R. Cookson, Michael E. Ward, Yue A. Qi

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Leucine-rich repeat kinase 2 controls protein kinase A activation state through phosphodiesterase 4 由 Isabella Russo, Giulietta Di Benedetto, Alice Kaganovich, Jinhui Ding, Daniela Mercatelli, Michele Morari, Mark R. Cookson, Luigi Bubacco, Elisa Greggio

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Major Shifts in Glial Regional Identity Are a Transcriptional Hallmark of Human Brain Aging 由 Lilach Soreq, Jamie Rose, Eyal Soreq, John Hardy, Daniah Trabzuni, Mark R. Cookson, Colin Smith, Mina Ryten, Rickie Patani, Jernej Ule

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PINK1 is selectively stabilized on impaired mitochondria to activate Parkin. 由 Derek P Narendra, Seok Min Jin, Atsushi Tanaka, Der-Fen Suen, Clement A Gautier, Jie Shen, Mark R Cookson, Richard J Youle

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Identification of Stk25 as a genetic modifier of Tau phosphorylation in Dab1-mutant mice. 由 Tohru Matsuki, Mariam Zaka, Rita Guerreiro, Marcel P van der Brug, Jonathan A Cooper, Mark R Cookson, John A Hardy, Brian W Howell

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Transcriptome analysis of LRRK2 knock-out microglia cells reveals alterations of inflammatory- and oxidative stress-related pathways upon treatment with α-synuclein fibrils 由 Isabella Russo, Alice Kaganovich, Jinhui Ding, Natalie Landeck, Adamantios Mamais, Tatiana Varanita, Alice Biosa, Isabella Tessari, Luigi Bubacco, Elisa Greggio, Mark R. Cookson

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