Combination therapy is superior to sequential monotherapy for the initial treatment of hypertension: A double-blind randomized controlled trial by MacDonald, TM, Williams, B, Webb, DJ, Morant, S, Caulfield, M, Cruickshank, JK, Ford, I, Sever, P, Mackenzie, IS, Padmanabhan, S, McCann, GP, Salsbury, J, McInnes, G, Brown, MJ, Schumann, A, Helmy, J, Maniero, C, Burton, TJ, Quinn, U, Hobbs, L, Palmer, J, Collier, D, Markandu, N, Saxena, M, Zak, A, Enobakhare, E, Mackay, J, Thom, SA, Coughlan, C, McGinnis, AR, Findlay, E, Stanley, AG, White, C, Lacy, P, Gardiner-Hill, CJ, Nazir, S, McInnes, GT, Muir, S, McCallum, L, Melville, V, MacIntyre, IM, Brown, R, Simon, R, Soran, H, Kwok, S, Balakrishnan, K, Hobbs, R, Iles, R, Myint, KS, Cannon, J, Hood, S, Rutkowski, K, Webb, A, Martin, U, Kean, S, Wilson, R, Papworth, R