S1PR3 agonism and S1P lyase inhibition rescue mice in the severe state of experimental sepsis by Anke C. Ziegler, Raphael S. Haider, Carsten Hoffmann, Markus H. Gräler

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Sphingosine-1 Phosphate Lyase Regulates Sensitivity of Pancreatic Beta-Cells to Lipotoxicity by Yadi Tang, Thomas Plötz, Markus H. Gräler, Ewa Gurgul-Convey

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Activation of Sphingomyelinase-Ceramide-Pathway in COVID-19 Purposes Its Inhibition for Therapeutic Strategies by Murad Abusukhun, Murad Abusukhun, Martin S. Winkler, Stefan Pöhlmann, Stefan Pöhlmann, Onnen Moerer, Konrad Meissner, Björn Tampe, Heike Hofmann-Winkler, Michael Bauer, Michael Bauer, Markus H. Gräler, Markus H. Gräler, Markus H. Gräler, Ralf A. Claus, Ralf A. Claus

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Evaluating Sphingosine and its Analogues as Potential Alternatives for Aggressive Lymphoma Treatment by Constantin Bode, Max Berlin, Franziska Röstel, Bianca Teichmann, Markus H. Gräler

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The Impact of Sphingosine Kinases on Inflammation-Induced Cytokine Release and Vascular Endothelial Barrier Integrity by Andreas V. Thuy, Christina-Maria Reimann, Anke C. Ziegler, Markus H. Gräler

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Sphingosine 1-Phosphate in Blood: Function, Metabolism, and Fate by Andreas V. Thuy, Christina-Maria Reimann, Nasr Y. A. Hemdan, Markus H. Gräler

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Inflammatory Conditions Disrupt Constitutive Endothelial Cell Barrier Stabilization by Alleviating Autonomous Secretion of Sphingosine 1-Phosphate by Jefri Jeya Paul, Cynthia Weigel, Tina Müller, Regine Heller, Sarah Spiegel, Markus H. Gräler

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Loss of sphingosine 1-phosphate (S1P) in septic shock is predominantly caused by decreased levels of high-density lipoproteins (HDL) by Martin Sebastian Winkler, Konstantin B. Märtz, Axel Nierhaus, Günter Daum, Edzard Schwedhelm, Stefan Kluge, Markus H. Gräler

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Altered Serum Phospholipids in Atopic Dermatitis and Association with Clinical Status by Takashi Sakai, Nadine Herrmann, Laura Maintz, Tim Joachim Nümm, Thomas Welchowski, Ralf A. Claus, Markus H. Gräler, Thomas Bieber

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Glucocorticoid activation of anti-inflammatory macrophages protects against insulin resistance by Giorgio Caratti, Ulrich Stifel, Bozhena Caratti, Ali J. M. Jamil, Kyoung-Jin Chung, Michael Kiehntopf, Markus H. Gräler, Matthias Blüher, Alexander Rauch, Jan P. Tuckermann

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Sphingosine-1-Phosphate (S1P) Lyase Inhibition Aggravates Atherosclerosis and Induces Plaque Rupture in <i>ApoE^−/−</i>  Mice by Petra Keul, Susann Peters, Karin von Wnuck Lipinski, Nathalie H. Schröder, Melissa K. Nowak, Dragos A. Duse, Amin Polzin, Sarah Weske, Markus H. Gräler, Bodo Levkau

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Long-Chain and Very Long-Chain Ceramides Mediate Doxorubicin-Induced Toxicity and Fibrosis by Tom Kretzschmar, Mohamed M. Bekhite, Jasmine M. F. Wu, Daniela Haase, Martin Förster, Tina Müller, Sandor Nietzsche, Martin Westermann, Marcus Franz, Markus H. Gräler, P. Christian Schulze

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Immunometabolic capacities of nutritional fatty acids in regulation of inflammatory bone cell interaction and systemic impact of periodontal infection by Annika Döding, Svenja Zimmermann, Ahmed Maghames, Michael Reimann, Judit Symmank, Maria Thürmer, Markus H. Gräler, Michael Wolf, Collin Jacobs, Andreas Koeberle, Andreas Koeberle, Bernd Sigusch, Ulrike Schulze-Späte

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Acid Sphingomyelinase Promotes Endothelial Stress Response in Systemic Inflammation and Sepsis by Ha-Yeun Chung, Daniel C Hupe, Gordon P Otto, Marcel Sprenger, Alexander C Bunck, Michael J Dorer, Clemens L Bockmeyer, Hans-Peter Deigner, Markus H Gräler, Ralf A Claus

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Intracellularly Released Cholesterol from Polymer-Based Delivery Systems Alters Cellular Responses to Pneumolysin and Promotes Cell Survival by Tobias Kammann, Jessica Hoff, Ilknur Yildirim, Blerina Shkodra, Tina Müller, Christine Weber, Markus H. Gräler, Ulrich A. Maus, James C. Paton, Mervyn Singer, Anja Traeger, Ulrich S. Schubert, Michael Bauer, Adrian T. Press

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S1P lyase inhibition protects against sepsis by promoting disease tolerance via the S1P/S1PR3 axis by Cynthia Weigel, Sören S. Hüttner, Kristin Ludwig, Nadine Krieg, Susann Hofmann, Nathalie H. Schröder, Linda Robbe, Stefan Kluge, Axel Nierhaus, Martin S. Winkler, Ignacio Rubio, Julia von Maltzahn, Sarah Spiegel, Markus H. Gräler

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Sphingosine‐1‐phosphate improves outcome of no‐reflow acute myocardial infarction via sphingosine‐1‐phosphate receptor 1 by Amin Polzin, Lisa Dannenberg, Marcel Benkhoff, Maike Barcik, Petra Keul, Aysel Ayhan, Sarah Weske, Samantha Ahlbrecht, Kajetan Trojovsky, Carolin Helten, Sebastian Haberkorn, Ulrich Flögel, Tobias Zeus, Tina Müller, Markus H. Gräler, Malte Kelm, Bodo Levkau

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Targeted delivery of a phosphoinositide 3‐kinase γ inhibitor to restore organ function in sepsis by Adrian T Press, Petra Babic, Bianca Hoffmann, Tina Müller, Wanling Foo, Walter Hauswald, Jovana Benecke, Martina Beretta, Zoltán Cseresnyés, Stephanie Hoeppener, Ivo Nischang, Sina M Coldewey, Markus H Gräler, Reinhard Bauer, Falk Gonnert, Nikolaus Gaßler, Reinhard Wetzker, Marc Thilo Figge, Ulrich S Schubert, Michael Bauer

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Sphingosine-1-phosphate suppresses GLUT activity through PP2A and counteracts hyperglycemia in diabetic red blood cells by Nadine Thomas, Nathalie H. Schröder, Melissa K. Nowak, Philipp Wollnitzke, Shahrooz Ghaderi, Karin von Wnuck Lipinski, Annalena Wille, Jennifer Deister-Jonas, Jens Vogt, Markus H. Gräler, Lisa Dannenberg, Tobias Buschmann, Philipp Westhoff, Amin Polzin, Malte Kelm, Petra Keul, Sarah Weske, Bodo Levkau

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Identification of Brain-Specific Treatment Effects in NPC1 Disease by Focusing on Cellular and Molecular Changes of Sphingosine-1-Phosphate Metabolism by Anne Gläser, Franziska Hammerl, Markus H. Gräler, Sina M. Coldewey, Christin Völkner, Moritz J. Frech, Fan Yang, Jiankai Luo, Eric Tönnies, Oliver von Bohlen und Halbach, Nicola Brandt, Diana Heimes, Anna-Maria Neßlauer, Georg Christoph Korenke, Marta Owczarek-Lipska, John Neidhardt, Arndt Rolfs, Andreas Wree, Martin Witt, Anja Ursula Bräuer

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