Editorial: CAR T-Cell Therapies in Hematologic Tumors by Marta Coscia, Benedetto Bruno, Sattva Neelapu

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CAR-modified Cellular Therapies in Chronic Lymphocytic Leukemia: Is the Uphill Road Getting Less Steep? by Candida Vitale, Valentina Griggio, Francesca Perutelli, Marta Coscia

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Immune Dysfunctions and Immune-Based Therapeutic Interventions in Chronic Lymphocytic Leukemia by Valentina Griggio, Valentina Griggio, Francesca Perutelli, Francesca Perutelli, Chiara Salvetti, Chiara Salvetti, Elia Boccellato, Elia Boccellato, Mario Boccadoro, Mario Boccadoro, Candida Vitale, Candida Vitale, Marta Coscia, Marta Coscia

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Zoledronic acid restores doxorubicin chemosensitivity and immunogenic cell death in multidrug-resistant human cancer cells. by Chiara Riganti, Barbara Castella, Joanna Kopecka, Ivana Campia, Marta Coscia, Gianpiero Pescarmona, Amalia Bosia, Dario Ghigo, Massimo Massaia

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Case Report: Sequential Development of Three Mature Lymphoid Neoplasms in a Single Patient: Clonal Relationship and Molecular Insights by Chiara Salvetti, Chiara Salvetti, Candida Vitale, Candida Vitale, Valentina Griggio, Daniela Drandi, Rebecca Jones, Lisa Bonello, Lisa Bonello, Riccardo Bomben, Alberto Bragoni, Davide Bagnara, Franco Fais, Franco Fais, Valter Gattei, Federica Cavallo, Federica Cavallo, Alberto Zamò, Marta Coscia, Marta Coscia

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MiR-155 deficiency and hypoxia results in metabolism switch in the leukemic B-cells by Elena Golovina, Tomas Heizer, Lenka Daumova, Martin Bajecny, Simona Fontana, Valentina Griggio, Rebecca Jones, Marta Coscia, Chiara Riganti, Karina Savvulidi Vargova

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The Advent of CAR T-Cell Therapy for Lymphoproliferative Neoplasms: Integrating Research Into Clinical Practice by Marco Cerrano, Marco Cerrano, Marco Ruella, Miguel-Angel Perales, Candida Vitale, Candida Vitale, Danilo Giuseppe Faraci, Danilo Giuseppe Faraci, Luisa Giaccone, Luisa Giaccone, Marta Coscia, Marta Coscia, Molly Maloy, Miriam Sanchez-Escamilla, Miriam Sanchez-Escamilla, Hesham Elsabah, Afraa Fadul, Enrico Maffini, Gianfranco Pittari, Benedetto Bruno, Benedetto Bruno

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The bone marrow of myeloma patients is steadily inhabited by a normal-sized pool of functional regulatory T cells irrespectiveof the disease status by Myriam Foglietta, Barbara Castella, Sara Mariani, Marta Coscia, Laura Godio, Riccardo Ferracini, Marina Ruggeri, Vittorio Muccio, Paola Omedé, Antonio Palumbo, Mario Boccadoro, Massimo Massaia

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The PD-1/PD-L1 axis contributes to T-cell dysfunction in chronic lymphocytic leukemia by Davide Brusa, Sara Serra, Marta Coscia, Davide Rossi, Giovanni D’Arena, Luca Laurenti, Ozren Jaksic, Giorgio Fedele, Giorgio Inghirami, Gianluca Gaidano, Fabio Malavasi, Silvia Deaglio

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Anergic bone marrow Vγ9Vδ2 T cells as early and long-lasting markers of PD-1-targetable microenvironment-induced immune suppression in human myeloma by Barbara Castella, Myriam Foglietta, Patrizia Sciancalepore, Micol Rigoni, Marta Coscia, Valentina Griggio, Candida Vitale, Riccardo Ferracini, Elona Saraci, Paola Omedé, Chiara Riganti, Antonio Palumbo, Mario Boccadoro, Massimo Massaia

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Anti-tumor activity of selinexor in combination with antineoplastic agents in chronic lymphocytic leukemia by Candida Vitale, Valentina Griggio, Maria Todaro, Chiara Riganti, Rebecca Jones, Elia Boccellato, Francesca Perutelli, Francesca Arruga, Tiziana Vaisitti, Dimitar G. Efremov, Silvia Deaglio, Yosef Landesman, Benedetto Bruno, Marta Coscia

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Regulatory T Cells and Their Prognostic Relevance in Hematologic Malignancies by Giovanni D’Arena, Candida Vitale, Marta Coscia, Agostino Festa, Nicola Matteo Dario Di Minno, Vincenzo De Feo, Michele Caraglia, Gioacchino Calapai, Luca Laurenti, Pellegrino Musto, Giovanni Di Minno, Daniela Fenoglio

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HLA-G is a component of the chronic lymphocytic leukemia escape repertoire to generate immune suppression: impact of the HLA-G 14 base pair (rs66554220) polymorphism by Roberta Rizzo, Valentina Audrito, Paola Vacca, Davide Rossi, Davide Brusa, Marina Stignani, Daria Bortolotti, Giovanni D’Arena, Marta Coscia, Luca Laurenti, Francesco Forconi, Gianluca Gaidano, Maria Cristina Mingari, Lorenzo Moretta, Fabio Malavasi, Silvia Deaglio

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Bendamustine and subcutaneous alemtuzumab combination is an effective treatment in relapsed/refractory chronic lymphocytic leukemia patients by Marco Montillo, Alessandra Tedeschi, Gianluca Gaidano, Marta Coscia, Valeria Belsito Petrizzi, Ester Orlandi, Nicola Cascavilla, Paolo Ghia, Marina Motta, Andrea Gallamini, Anna Maria Frustaci, Davide Rossi, Lorenzo De Paoli, Michele Nichelatti, Enrica Morra, Massimo Massaia

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The immunomodulatory molecule TIGIT is expressed by chronic lymphocytic leukemia cells and contributes to anergy by Francesca Arruga, Marta Rubin, Despoina Papazoglou, Andrea Iannello, Nikolaos Ioannou, Riccardo Moia, Davide Rossi, Gianluca Gaidano, Marta Coscia, Luca Laurenti, Giovanni D’Arena, John N. Allan, Richard R. Furman, Tiziana Vaisitti, Alan G. Ramsay, Silvia Deaglio

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Adenosine signaling mediates hypoxic responses in the chronic lymphocytic leukemia microenvironment by Sara Serra, Tiziana Vaisitti, Valentina Audrito, Cinzia Bologna, Roberta Buonincontri, Shih-Shih Chen, Francesca Arruga, Davide Brusa, Marta Coscia, Ozren Jaksic, Giorgio Inghirami, Davide Rossi, Richard R. Furman, Simon C. Robson, Gianluca Gaidano, Nicholas Chiorazzi, Silvia Deaglio

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S147: EFFICACY AND SAFETY RESULTS OF MOLTO, A MULTICENTER, OPEN LABEL, PHASE II CLINICAL TRIAL EVALUATING VENETOCLAX, ATEZOLIZUMAB AND OBINUTUZUMAB COMBINATION IN RICHTER SYNDROME by Anna Maria Frustaci, Marco Montillo, Davide Rossi, Pier Luigi Zinzani, Marina Motta, Gianluca Gaidano, Giulia Quaresmini, Lydia Scarfò, Daniela Pietrasanta, Marta Coscia, Marina Deodato, Giulia Zamprogna, Roberto Cairoli, Georg Stüssi, Emanuele Zucca, Stefano Pileri, Thorsten Zenz, Alessandra Tedeschi

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COVID-19 in patients with chronic lymphocytic leukemia treated with venetoclax: what is the role of anti-CD20 antibody? by Francesco Autore, Andrea Visentin, Marina Deodato, Candida Vitale, Eugenio Galli, Alberto Fresa, Rita Fazzi, Alessandro Sanna, Jacopo Olivieri, Ilaria Scortechini, Maria Ilaria Del Principe, Paolo Sportoletti, Idanna Innocenti, Marta Coscia, Alessandra Tedeschi, Livio Trentin, Anna Candoni, Alessandro Busca, Livio Pagano, Luca Laurenti

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A phase II multi-center trial of pentostatin plus cyclophosphamide with ofatumumab in older previously untreated chronic lymphocytic leukemia patients by Alessandra Tedeschi, Davide Rossi, Marina Motta, Giulia Quaresmini, Marianna Rossi, Marta Coscia, Antonella Anastasia, Fausto Rossini, Agostino Cortelezzi, Guido Nador, Lydia Scarfò, Roberto Cairoli, Anna Maria Frustaci, Daniela Dalceggio, Paola Picardi, Lorenzo De Paoli, Ester Orlandi, Alessandro Rambaldi, Massimo Massaia, Gianluca Gaidano, Marco Montillo

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P1509: CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND PREVIOUS INFECTIONS HAD IMPACT ON INFECTIOUS COMPLICATIONS IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA TREATED WITH VENETOCLAX: A... by Francesco Autore, Andrea Visentin, Marina Deodato, Candida Vitale, Eugenio Galli, Alberto Fresa, Rita Fazzi, Alessandro Sanna, Jacopo Olivieri, Ilaria Scortechini, Maria Ilaria DEL Principe, Paolo Sportoletti, Luana Schiattone, Nilla Maschio, Davide Facchinelli, Marta Coscia, Alessandra Tedeschi, Livio Trentin, Idanna Innocenti, Anna Candoni, Alessandro Busca, Livio Pagano, Luca Laurenti

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