Management of severe sepsis: advances, challenges, and current status by Martin-Loeches I, Levy MM, Artigas A

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Mortality associated with early changes in ARDS severity in COVID–19 patients – Insights from the PRoVENT–COVID study by Schuijt, MTU, Martin-Loeches, I, Schultz, MJ, Paulus, F, Neto, AS

Association of time-varying intensity of ventilation with mortality in patients with COVID-19 ARDS: Secondary analysis of the PRoVENT-COVID Study by Schuijt, MTU, van Meenen, DMP, Martin-Loeches, I, Mazzinari, G, Schultz, MJ, Paulus, F, Serpa Neto, A

Checklist for early recognition and treatment of acute illness and injury: An exploratory multicenter international quality-improvement study in the ICUs with variable resources by Vukoja, M, Dong, Y, Adhikari, NKJ, Schultz, MJ, Arabi, YM, Martin-Loeches, I, Hache, M, Gavrilovic, S, Kashyap, R, Gajic, O

A targeted likelihood estimation comparing cefepime and piperacillin/tazobactam in critically ill patients with community-acquired pneumonia (CAP) by Serrano-Mayorga, CC, Duque, S, Ibáñez-Prada, ED, Garcia-Gallo, E, Arrieta, MPR, Bastidas, A, Rodríguez, A, Martin-Loeches, I, Reyes, LF

Major alteration of lung microbiome and the host responses in critically ill COVID-19 patients with high viral load by Bustos, IG, Wiscovitch-Russo, R, Singh, H, Sievers, BL, Matsuoka, M, Freire, M, Tan, GS, Cala, MP, Guerrero, JL, Martin-Loeches, I, Gonzalez-Juarbe, N, Reyes, LF

Implementation of recommendations on the use of corticosteroids in severe COVID-19 by Camirand-Lemyre, F, Merson, L, Tirupakuzhi Vijayaraghavan, BK, Burrell, AJC, Citarella, BW, Domingue, M-P, Lévesque, S, Usuf, E, Wils, E-J, Ohshimo, S, Martin-Loeches, I, Sandulescu, O, Laake, JH, Lamontagne, F

Untargeted molecular analysis of exhaled breath as a diagnostic test for ventilator-associated lower respiratory tract infections (BreathDx) by van Oort, PM, Nijsen, TM, White, IR, Knobel, HH, Felton, T, Rattray, N, Lawal, O, Bulut, M, Ahmed, W, Artigas, A, Povoa, PR, Martin-Loeches, I, Weda, H, Goodacre, R, Schultz, MJ, Dark, PM, Fowler, SJ, Bos, LD

Major adverse cardiovascular events (MACE) in patients with severe COVID-19 registered in the ISARIC WHO clinical characterization protocol: a prospective, multinational, observati... by Reyes, LF, Garcia-Gallo, E, Murthy, S, Fuentes, YV, Serrano, CC, Ibáñez-Prada, ED, Lee, J, Rojek, A, Citarella, BW, Gonçalves, BP, Dunning, J, Rätsep, I, Viñan-Garces, AE, Kartsonaki, C, Rello, J, Martin-Loeches, I, Shankar-Hari, M, Olliaro, PL, Merson, L

A multi-country analysis of COVID-19 hospitalizations by vaccination status by Gonçalves, BP, Jassat, W, Baruch, J, Hashmi, M, Rojek, A, Dasgupta, A, Martin-Loeches, I, Reyes, LF, Piubelli, C, Citarella, BW, Kartsonaki, C, Lefèvre, B, López Revilla, JW, Lunn, M, Harrison, EM, Kraemer, MUG, Shrapnel, S, Horby, P, Bisoffi, Z, Olliaro, PL, Merson, L

Epidemiology, ventilation management and outcomes of COVID–19 ARDS patients versus patients with ARDS due to pneumonia in the Pre–COVID era by van der Ven, FLIM, Blok, SG, Azevedo, LC, Bellani, G, Botta, M, Estenssoro, E, Fan, E, Ferreira, JC, Laffey, JG, Martin–Loeches, I, Motos, A, Pham, T, Peñuelas, O, Pesenti, A, Pisani, L, Neto, AS, Schultz, MJ, Torres, A, Tsonas, AM, Paulus, F, van Meenen, DMP

Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, obs... by Reyes, LF, Murthy, S, Garcia-Gallo, E, Merson, L, Ibáñez-Prada, ED, Rello, J, Fuentes, YV, Martin-Loeches, I, Bozza, F, Duque, S, Taccone, FS, Fowler, RA, Kartsonaki, C, Gonçalves, BP, Citarella, BW, Aryal, D, Burhan, E, Cummings, MJ, Delmas, C, Diaz, R, Figueiredo-Mello, C, Hashmi, M, Panda, PK, Jiménez, MP, Rincon, DFB, Thomson, D, Nichol, A, Marshall, JC, Olliaro, PL

Characteristics and outcomes of COVID-19 patients admitted to hospital with and without respiratory symptoms by Citarella, BW, Kartsonaki, C, Ibáñez-Prada, ED, Gonçalves, BP, Baruch, J, Escher, M, Pritchard, MG, Wei, J, Philippy, F, Dagens, A, Hall, M, Lee, J, Kutsogiannis, DJ, Wils, E-J, Fernandes, MA, Tirupakuzhi Vijayaraghavan, BK, Panda, PK, Martin-Loeches, I, Ohshimo, S, Fatoni, AZ, Horby, P, Dunning, J, Rello, J, Merson, L, Rojek, A, Vaillant, M, Olliaro, P, Reyes, LF, ISARIC Clinical Characterisation Group

Current challenges in the management of sepsis in ICUs in resource–poor settings and suggestions for the future by Thwaites, C, Schultz, M, Dunser, M, Dondorp, A, Adhikari, N, Iyer, S, Kwizera, A, Lubell, Y, Papali, A, Pisani, L, Riviello, B, Angus, D, Azevedo, L, Baker, T, Diaz, J, Festic, E, Haniffa, R, Jawa, R, Jacob, S, Kissoon, N, Lodha, R, Martin-Loeches, I, Lundeg, G, Misango, D, Mer, M, Mohanty, S, Murthy, S, Musa, N, Nakibuuka, J, Neto, A, Mai, N, Binh, N, Pattnaik, R, Phua, J, Preller, J, Povoa, P, Ranjit, S, Talmor, D, Thevanayagam, J

Clinical characteristics, risk factors and outcomes in patients with severe COVID-19 registered in the International Severe Acute Respiratory and Emerging Infection Consortium WHO... by Reyes, LF, Murthy, S, Garcia-Gallo, E, Irvine, M, Merson, L, Martin-Loeches, I, Rello, J, Taccone, FS, Fowler, RA, Docherty, AB, Kartsonaki, C, Aragao, I, Barrett, PW, Beane, A, Burrell, A, Cheng, MP, Christian, MD, Cidade, JP, Citarella, BW, Donnelly, CA, Fernandes, SM, French, C, Haniffa, R, Harrison, EM, Ho, AYW, Joseph, M, Khan, I, Kho, ME, Kildal, AB, Kutsogiannis, D, Lamontagne, F, Lee, TC, Bassi, GL, Lopez Revilla, JW, Marquis, C, Millar, J, Neto, R, Nichol, A, Parke, R, Pereira, R, Poli, S, Povoa, P, Ramanathan, K, Rewa, O, Riera, J, Shrapnel, S, Silva, MJ, Udy, A, Uyeki, T, Webb, SA

Characteristics and outcomes of an international cohort of 600 000 hospitalized patients with COVID-19 by Kartsonaki, C, Baillie, JK, Barrio, NG, Baruch, J, Beane, A, Blumberg, L, Bozza, F, Broadley, T, Burrell, A, Carson, G, Citarella, BW, Dagens, A, Dankwa, EA, Donnelly, CA, Dunning, J, Elotmani, L, Escher, M, Farshait, N, Goffard, J-C, Gonçalves, BP, Hall, M, Hashmi, M, Sim Lim Heng, B, Ho, A, Jassat, W, Pedrera Jiménez, M, Laouenan, C, Lissauer, S, Martin-Loeches, I, Mentré, F, Merson, L, Morton, B, Munblit, D, Nekliudov, NA, Nichol, AD, Singh Oinam, BC, Ong, D, Panda, PK, Petrovic, M, Pritchard, MG, Ramakrishnan, N, Ramos, GV, Roger, C, Sandulescu, O, Semple, MG, Sharma, P, Sigfrid, L, Somers, EC, Streinu-Cercel, A, Taccone, F, Vecham, PK, Vijayaraghavan, BKT, Wei, J, Wils, E-J, Wong, XC, Horby, P, Rojek, A, Olliaro, PL