P125: Whole-genome sequencing in the NICU: Improving healthcare through precision medicine by Danielle Bonser, Martin Tristani-Firouzi, Rachel Palmquist, Sabrina Malone-Jenkins

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De novo variants in exomes of congenital heart disease patients identify risk genes and pathways by Cigdem Sevim Bayrak, Peng Zhang, Martin Tristani-Firouzi, Bruce D. Gelb, Yuval Itan

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The application of root mean square electrocardiography (RMS ECG) for the detection of acquired and congenital long QT syndrome. by Robert L Lux, Christopher Todd Sower, Nancy Allen, Susan P Etheridge, Martin Tristani-Firouzi, Elizabeth V Saarel

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Modeling effects of voltage dependent properties of the cardiac muscarinic receptor on human sinus node function. by Robin Moss, Frank B Sachse, Eloy G Moreno-Galindo, Ricardo A Navarro-Polanco, Martin Tristani-Firouzi, Gunnar Seemann

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Expanding the phenotype of CACNA1C mutation disorders by Lindsey Gakenheimer‐Smith, Lindsay Meyers, Derek Lundahl, Shaji C. Menon, T. Jared Bunch, Briana L. Sawyer, Martin Tristani‐Firouzi, Susan P. Etheridge

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Functional and Pharmacological Analysis of Cardiomyocytes Differentiated from Human Peripheral Blood Mononuclear-Derived Pluripotent Stem Cells by Michael Riedel, Chuanchau J. Jou, Shuping Lai, Robert L. Lux, Alonso P. Moreno, Kenneth W. Spitzer, Elizabeth Christians, Martin Tristani-Firouzi, Ivor J. Benjamin

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3-OST-7 regulates BMP-dependent cardiac contraction. by Shiela C Samson, Tania Ferrer, Chuanchau J Jou, Frank B Sachse, Sunita S Shankaran, Robin M Shaw, Neil C Chi, Martin Tristani-Firouzi, H Joseph Yost

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Common Variation in Cytoskeletal Genes Is Associated with Conotruncal Heart Defects by Fadi I. Musfee, A. J. Agopian, Elizabeth Goldmuntz, Hakon Hakonarson, Bernice E. Morrow, Deanne M. Taylor, Martin Tristani-Firouzi, W. Scott Watkins, Mark Yandell, Laura E. Mitchell

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Kv1.5 Open Channel Block by the Antiarrhythmic Drug Disopyramide: Molecular Determinants of Block by Iván A. Aréchiga, Gabriel F. Barrio-Echavarria, Aldo A. Rodríguez-Menchaca, Eloy G. Moreno-Galindo, Niels Decher, Martin Tristani-Firouzi, José A. Sánchez-Chapula, Ricardo A. Navarro-Polanco

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Effective variant filtering and expected candidate variant yield in studies of rare human disease by Brent S. Pedersen, Joe M. Brown, Harriet Dashnow, Amelia D. Wallace, Matt Velinder, Martin Tristani-Firouzi, Joshua D. Schiffman, Tatiana Tvrdik, Rong Mao, D. Hunter Best, Pinar Bayrak-Toydemir, Aaron R. Quinlan

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Genetic and physiologic dissection of the vertebrate cardiac conduction system. by Neil C Chi, Robin M Shaw, Benno Jungblut, Jan Huisken, Tania Ferrer, Rima Arnaout, Ian Scott, Dimitris Beis, Tong Xiao, Herwig Baier, Lily Y Jan, Martin Tristani-Firouzi, Didier Y R Stainier

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Addressing ethical and laboratory challenges for initiation of a rapid whole genome sequencing program by Sabrina Malone Jenkins, Rachel Palmquist, Ashley L. Kapron, Carrie Torr, D. Hunter Best, Mary Anne Karren, Luca Brunelli, Mark Yandell, Martin Tristani-Firouzi, David Dimmock, Brian Watts, Jeffrey R. Botkin, Ann Johnson, Joshua L. Bonkowsky

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A Functional Assay for Sick Sinus Syndrome Genetic Variants by Chuanchau J. Jou, Cammon B. Arrington, Spencer Barnett, Jiaxiang Shen, Scott Cho, Xiaoming Sheng, Patrick C. McCullagh, Neil E. Bowles, Chase M. Pribble, Elizabeth V. Saarel, Thomas A. Pilcher, Susan P. Etheridge, Martin Tristani-Firouzi

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An explainable artificial intelligence approach for predicting cardiovascular outcomes using electronic health records. by Sergiusz Wesołowski, Gordon Lemmon, Edgar J Hernandez, Alex Henrie, Thomas A Miller, Derek Weyhrauch, Michael D Puchalski, Bruce E Bray, Rashmee U Shah, Vikrant G Deshmukh, Rebecca Delaney, H Joseph Yostl, Karen Eilbeck, Martin Tristani-Firouzi, Mark Yandell

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Efficient Precision Genome Editing in iPSCs via Genetic Co-targeting with Selection by Katie A. Mitzelfelt, Chris McDermott-Roe, Michael N. Grzybowski, Maribel Marquez, Chieh-Ti Kuo, Michael Riedel, Shuping Lai, Melinda J. Choi, Kurt D. Kolander, Daniel Helbling, David P. Dimmock, Michele A. Battle, Chuanchau J. Jou, Martin Tristani-Firouzi, James W. Verbsky, Ivor J. Benjamin, Aron M. Geurts

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De novo and recessive forms of congenital heart disease have distinct genetic and phenotypic landscapes by W. Scott Watkins, E. Javier Hernandez, Sergiusz Wesolowski, Brent W. Bisgrove, Ryan T. Sunderland, Edwin Lin, Gordon Lemmon, Bradley L. Demarest, Thomas A. Miller, Daniel Bernstein, Martina Brueckner, Wendy K. Chung, Bruce D. Gelb, Elizabeth Goldmuntz, Jane W. Newburger, Christine E. Seidman, Yufeng Shen, H. Joseph Yost, Mark Yandell, Martin Tristani-Firouzi

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American Heart Association's Children's Strategically Focused Research Network Experience by Craig Sable, Jennifer S. Li, Martin Tristani‐Firouzi, Angela Fagerlin, Robert M. Silver, Mark Yandel, H. Joseph Yost, Andrea Beaton, James Dale, Mark Emmanuel Engel, David Watkins, Christopher Spurney, Asheley C. Skinner, Sarah C. Armstrong, Svati H. Shah, Norrina Allen, Matthew Davis, Lifang Hou, Linda Van Horn, Darwin Labarthe, Donald Lloyd‐Jones, Bradley Marino

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Author Correction: Mitochondrial calcium uniporter stabilization preserves energetic homeostasis during Complex I impairment by Enrique Balderas, David R. Eberhardt, Sandra Lee, John M. Pleinis, Salah Sommakia, Anthony M. Balynas, Xue Yin, Mitchell C. Parker, Colin T. Maguire, Scott Cho, Marta W. Szulik, Anna Bakhtina, Ryan D. Bia, Marisa W. Friederich, Timothy M. Locke, Johan L. K. Van Hove, Stavros G. Drakos, Yasemin Sancak, Martin Tristani-Firouzi, Sarah Franklin, Aylin R. Rodan, Dipayan Chaudhuri

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Rare genetic variation at transcription factor binding sites modulates local DNA methylation profiles. by Alejandro Martin-Trujillo, Nihir Patel, Felix Richter, Bharati Jadhav, Paras Garg, Sarah U Morton, David M McKean, Steven R DePalma, Elizabeth Goldmuntz, Dorota Gruber, Richard Kim, Jane W Newburger, George A Porter, Alessandro Giardini, Daniel Bernstein, Martin Tristani-Firouzi, Jonathan G Seidman, Christine E Seidman, Wendy K Chung, Bruce D Gelb, Andrew J Sharp

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Mitochondrial calcium uniporter stabilization preserves energetic homeostasis during Complex I impairment by Enrique Balderas, David R. Eberhardt, Sandra Lee, John M. Pleinis, Salah Sommakia, Anthony M. Balynas, Xue Yin, Mitchell C. Parker, Colin T. Maguire, Scott Cho, Marta W. Szulik, Anna Bakhtina, Ryan D. Bia, Marisa W. Friederich, Timothy M. Locke, Johan L. K. Van Hove, Stavros G. Drakos, Yasemin Sancak, Martin Tristani-Firouzi, Sarah Franklin, Aylin R. Rodan, Dipayan Chaudhuri

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