Microglial APOE4: more is less and less is more -н Ghazaleh Eskandari-Sedighi, Mathew Blurton-Jones

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CRISPR generation of CSF1R-G795A human microglia for robust microglia replacement in a chimeric mouse model -н Jean Paul Chadarevian, Hayk Davtyan, Sonia I. Lombroso, F. Chris Bennett, Mathew Blurton-Jones

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Development and validation of a simplified method to generate human microglia from pluripotent stem cells -н Amanda McQuade, Morgan Coburn, Christina H. Tu, Jonathan Hasselmann, Hayk Davtyan, Mathew Blurton-Jones

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Using Advanced Diffusion-Weighted Imaging to Predict Cell Counts in Gray Matter: Potential and Pitfalls -н Hamsanandini Radhakrishnan, Sepideh Kiani Shabestari, Mathew Blurton-Jones, Andre Obenaus, Craig E. L. Stark, Craig E. L. Stark

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HuCNS-SC Human NSCs Fail to Differentiate, Form Ectopic Clusters, and Provide No Cognitive Benefits in a Transgenic Model of Alzheimer's Disease -н Samuel E. Marsh, Stephen T. Yeung, Maria Torres, Lydia Lau, Joy L. Davis, Edwin S. Monuki, Wayne W. Poon, Mathew Blurton-Jones

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Humanized monoclonal antibody armanezumab specific to N-terminus of pathological tau: characterization and therapeutic potency -н Michael G. Agadjanyan, Karen Zagorski, Irina Petrushina, Hayk Davtyan, Konstantin Kazarian, Maxim Antonenko, Joy Davis, Charles Bon, Mathew Blurton-Jones, David H. Cribbs, Anahit Ghochikyan

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Microglial APOE3 Christchurch protects neurons from Tau pathology in a human iPSC-based model of Alzheimer’s disease -н Guoqiang George Sun, Cheng Wang, Randall C. Mazzarino, Paula Andrea Perez-Corredor, Hayk Davtyan, Mathew Blurton-Jones, Francisco Lopera, Joseph F. Arboleda-Velasquez, Yanhong Shi

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Correction: Neural stem cells genetically-modified to express neprilysin reduce pathology in Alzheimer transgenic models -н Mathew Blurton-Jones, Brian Spencer, Sara Michael, Nicholas A. Castello, Andranik A. Agazaryan, Joy L. Davis, Franz-Josef Müller, Jeanne F. Loring, Eliezer Masliah, Frank M. LaFerla

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Astrocytic response mediated by the CLU risk allele inhibits OPC proliferation and myelination in a human iPSC model -н Zhenqing Liu, Jianfei Chao, Cheng Wang, Guihua Sun, Daniel Roeth, Wei Liu, Xianwei Chen, Li Li, E Tian, Lizhao Feng, Hayk Davtyan, Mathew Blurton-Jones, Markus Kalkum, Yanhong Shi

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BDNF rescues BAF53b-dependent synaptic plasticity and cocaine-associated memory in the nucleus accumbens -н André O. White, Enikö A. Kramár, Alberto J. López, Janine L. Kwapis, John Doan, David Saldana, M. Felicia Davatolhagh, Yasaman Alaghband, Mathew Blurton-Jones, Dina P. Matheos, Marcelo A. Wood

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Human neural cell type‐specific extracellular vesicle proteome defines disease‐related molecules associated with activated astrocytes in Alzheimer's disease brain -н Yang You, Satoshi Muraoka, Mark P. Jedrychowski, Jianqiao Hu, Amanda K. McQuade, Tracy Young‐Pearse, Roshanak Aslebagh, Scott A. Shaffer, Steven P. Gygi, Mathew Blurton‐Jones, Wayne W. Poon, Tsuneya Ikezu

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TREM2 regulates purinergic receptor-mediated calcium signaling and motility in human iPSC-derived microglia -н Amit Jairaman, Amanda McQuade, Alberto Granzotto, You Jung Kang, Jean Paul Chadarevian, Sunil Gandhi, Ian Parker, Ian Smith, Hansang Cho, Stefano L Sensi, Shivashankar Othy, Mathew Blurton-Jones, Michael D Cahalan

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Moderate intrinsic phenotypic alterations in C9orf72 ALS/FTD iPSC-microglia despite the presence of C9orf72 pathological features -н Ileana Lorenzini, Eric Alsop, Jennifer Levy, Lauren M. Gittings, Deepti Lall, Benjamin E. Rabichow, Stephen Moore, Stephen Moore, Ryan Pevey, Ryan Pevey, Lynette M. Bustos, Lynette M. Bustos, Camelia Burciu, Divya Bhatia, Mo Singer, Justin Saul, Amanda McQuade, Amanda McQuade, Amanda McQuade, Makis Tzioras, Makis Tzioras, Thomas A. Mota, Amber Logemann, Jamie Rose, Jamie Rose, Sandra Almeida, Fen-Biao Gao, Michael Marks, Christopher J. Donnelly, Elizabeth Hutchins, Shu-Ting Hung, Justin Ichida, Robert Bowser, Tara Spires-Jones, Tara Spires-Jones, Mathew Blurton-Jones, Mathew Blurton-Jones, Mathew Blurton-Jones, Tania F. Gendron, Tania F. Gendron, Robert H. Baloh, Robert H. Baloh, Kendall Van Keuren-Jensen, Rita Sattler

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Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology -н Fiona E. McAlpine, Jae-Kyung Lee, Ashley S. Harms, Kelly A. Ruhn, Mathew Blurton-Jones, John Hong, Pritam Das, Todd E. Golde, Frank M. LaFerla, Salvatore Oddo, Armin Blesch, Malú G. Tansey

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Testing a MultiTEP-based combination vaccine to reduce Aβ and tau pathology in Tau22/5xFAD bigenic mice -н Hayk Davtyan, Armine Hovakimyan, Sepideh Kiani Shabestari, Tatevik Antonyan, Morgan A. Coburn, Karen Zagorski, Gor Chailyan, Irina Petrushina, Olga Svystun, Emma Danhash, Nikolai Petrovsky, David H. Cribbs, Michael G. Agadjanyan, Mathew Blurton-Jones, Anahit Ghochikyan

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Neurotoxic Microglial Activation via IFNγ‐Induced Nrf2 Reduction Exacerbating Alzheimer's Disease -н You Jung Kang, Seung Jae Hyeon, Amanda McQuade, Jiwoon Lim, Seung Hyun Baek, Yen N. Diep, Khanh V. Do, Yeji Jeon, Dong‐Gyu Jo, C. Justin Lee, Mathew Blurton‐Jones, Hoon Ryu, Hansang Cho

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Exosome loaded immunomodulatory biomaterials alleviate local immune response in immunocompetent diabetic mice post islet xenotransplantation -н M. Rezaa Mohammadi, Samuel Mathew Rodriguez, Jennifer Cam Luong, Shiri Li, Rui Cao, Hamad Alshetaiwi, Hien Lau, Hayk Davtyan, Mathew Blurton Jones, Mahtab Jafari, Kai Kessenbrock, S. Armando Villalta, Paul de Vos, Weian Zhao, Jonathan R. T. Lakey

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Characterization and preclinical evaluation of the cGMP grade DNA based vaccine, AV-1959D to enter the first-in-human clinical trials -н Irina Petrushina, Armine Hovakimyan, Indira S. Harahap-Carrillo, Hayk Davtyan, Tatevik Antonyan, Gor Chailyan, Konstantin Kazarian, Maxim Antonenko, Amandine Jullienne, Mary M. Hamer, Andre Obenaus, Olga King, Karen Zagorski, Mathew Blurton-Jones, David H. Cribbs, Harry Lander, Anahit Ghochikyan, Michael G. Agadjanyan

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Mitochondria dysregulation contributes to secondary neurodegeneration progression post-contusion injury in human 3D in vitro triculture brain tissue model -н Volha Liaudanskaya, Nicholas J. Fiore, Yang Zhang, Yuka Milton, Marilyn F. Kelly, Marly Coe, Ariana Barreiro, Victoria K. Rose, Matthew R. Shapiro, Adam S. Mullis, Anna Shevzov-Zebrun, Mathew Blurton-Jones, Michael J. Whalen, Aviva J. Symes, Irene Georgakoudi, Thomas J. F. Nieland, David L. Kaplan

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Single-nuclei transcriptome analysis of Huntington disease iPSC and mouse astrocytes implicates maturation and functional deficits -н Andrea M. Reyes-Ortiz, Edsel M. Abud, Mara S. Burns, Jie Wu, Sarah J. Hernandez, Nicolette McClure, Keona Q. Wang, Corey J. Schulz, Ricardo Miramontes, Alice Lau, Neethu Michael, Emily Miyoshi, David Van Vactor, John C. Reidling, Mathew Blurton-Jones, Vivek Swarup, Wayne W. Poon, Ryan G. Lim, Leslie M. Thompson

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