Editorial: Effector functions of therapeutic antibodies by Peter Boross, Matthias Peipp, Falk Nimmerjahn

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Balancing the CD38 Expression on Effector and Target Cells in Daratumumab-Mediated NK Cell ADCC against Multiple Myeloma by Margaux Lejeune, Elodie Duray, Matthias Peipp, Béatrice Clémenceau, Frédéric Baron, Yves Beguin, Jo Caers

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Galectin-3 Released by Pancreatic Ductal Adenocarcinoma Suppresses γδ T Cell Proliferation but Not Their Cytotoxicity by Daniel Gonnermann, Hans-Heinrich Oberg, Marcus Lettau, Matthias Peipp, Dirk Bauerschlag, Susanne Sebens, Dieter Kabelitz, Daniela Wesch

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Vdelta1 T cells are more resistant than Vdelta2 T cells to the immunosuppressive properties of galectin-3 by Jan Schadeck, Hans-Heinrich Oberg, Matthias Peipp, Nina Hedemann, Wolfgang W. Schamel, Wolfgang W. Schamel, Dirk Bauerschlag, Daniela Wesch

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Enhanced ADCC activity of affinity maturated and Fc-engineered mini-antibodies directed against the AML stem cell antigen CD96. by Sahar Mohseni Nodehi, Roland Repp, Christian Kellner, Joachim Bräutigam, Matthias Staudinger, Natalie Schub, Matthias Peipp, Martin Gramatzki, Andreas Humpe

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424 Adoptive cell therapy with cytokine-induces killer cells armed with immunotools against Her-2 expressing breast cancer by Gaia Griguolo, Anna Dalla Pietà, Elisa Cappuzzello, Annavera Ventura, Roberta Sommaggio, Antonio Rosato, Hieu Trong Ngo, Emilia Vigolo, Giulia D’Accardio, Sara Perpinello, Matthias Peipp

Molecular Mechanisms by Which a Fucus vesiculosus Extract Mediates Cell Cycle Inhibition and Cell Death in Pancreatic Cancer Cells by Ulf Geisen, Marion Zenthoefer, Matthias Peipp, Jannik Kerber, Johannes Plenge, Antonella Managò, Markus Fuhrmann, Roland Geyer, Steffen Hennig, Dieter Adam, Levent Piker, Gerald Rimbach, Holger Kalthoff

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TRAIL-Receptor 4 Modulates γδ T Cell-Cytotoxicity Toward Cancer Cells by Doaa Tawfik, Christopher Groth, Christopher Groth, Jan-Paul Gundlach, Jan-Paul Gundlach, Matthias Peipp, Dieter Kabelitz, Thomas Becker, Hans-Heinrich Oberg, Anna Trauzold, Anna Trauzold, Daniela Wesch

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1005 BiXAb® MAIT Engagers: solving the problems of classical T-cell engagers in the treatment of solid tumors by Claire Germain, Matthias Peipp, Simon E Plyte, Marie Fraudeau, Dorothee Winterberg, Camille Rousseau, Gaetano Sodaro, Maxime Audin, Alexandre Ivagnes, Hans Heinrich Oberg, Pierre Emmanuel Gerard, Daniela Wesch, Julie Prigent

Identification of New Antibodies Targeting Malignant Plasma Cells for Immunotherapy by Next-Generation Sequencing-Assisted Phage Display by Steffen Krohn, Ammelie Svea Boje, Carina Lynn Gehlert, Sebastian Lutz, Nikos Darzentas, Henrik Knecht, Dietrich Herrmann, Monika Brüggemann, Axel J. Scheidig, Katja Weisel, Martin Gramatzki, Matthias Peipp, Katja Klausz

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Engineering of CD19 Antibodies: A CD19-TRAIL Fusion Construct Specifically Induces Apoptosis in B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) Cells In Vivo by Dorothee Winterberg, Lennart Lenk, Maren Oßwald, Fotini Vogiatzi, Carina Lynn Gehlert, Fabian-Simon Frielitz, Katja Klausz, Thies Rösner, Thomas Valerius, Anna Trauzold, Matthias Peipp, Christian Kellner, Denis Martin Schewe

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Minimal B Cell Extrinsic IgG Glycan Modifications of Pro- and Anti-Inflammatory IgG Preparations in vivo by Anja Schaffert, Maja Hanić, Mislav Novokmet, Olga Zaytseva, Jasminka Krištić, Anja Lux, Lars Nitschke, Matthias Peipp, Marija Pezer, René Hennig, René Hennig, Erdmann Rapp, Erdmann Rapp, Gordan Lauc, Gordan Lauc, Falk Nimmerjahn

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Enhancing CDC and ADCC of CD19 Antibodies by Combining Fc Protein-Engineering with Fc Glyco-Engineering by Sophia Roßkopf, Klara Marie Eichholz, Dorothee Winterberg, Katarina Julia Diemer, Sebastian Lutz, Ira Alexandra Münnich, Katja Klausz, Thies Rösner, Thomas Valerius, Denis Martin Schewe, Andreas Humpe, Martin Gramatzki, Matthias Peipp, Christian Kellner

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Myeloid checkpoint blockade improves killing of T-acute lymphoblastic leukemia cells by an IgA2 variant of daratumumab by Niklas Baumann, Christian Arndt, Judith Petersen, Marta Lustig, Thies Rösner, Katja Klausz, Christian Kellner, Miriam Bultmann, Lorenz Bastian, Fotini Vogiatzi, Jeanette H. W. Leusen, Renate Burger, Denis M. Schewe, Matthias Peipp, Thomas Valerius

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Enhanced potency of immunotherapy against B‐cell precursor acute lymphoblastic leukemia by combination of an Fc‐engineered CD19 antibody and CD47 blockade by Denis M. Schewe, Fotini Vogiatzi, Ira A. Münnich, Tobias Zeller, Roland Windisch, Christian Wichmann, Kristina Müller, Hilal Bhat, Elisa Felix, Dimitrios Mougiakakos, Heiko Bruns, Lennart Lenk, Thomas Valerius, Andreas Humpe, Matthias Peipp, Christian Kellner

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Impact of antibody architecture and paratope valency on effector functions of bispecific NKp30 x EGFR natural killer cell engagers by Ammelie Svea Boje, Lukas Pekar, Katharina Koep, Britta Lipinski, Brian Rabinovich, Andreas Evers, Carina Lynn Gehlert, Steffen Krohn, Yanping Xiao, Simon Krah, Rinat Zaynagetdinov, Lars Toleikis, Sven Poetzsch, Matthias Peipp, Stefan Zielonka, Katja Klausz

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Generation and engineering of potent single domain antibody-based bispecific IL-18 mimetics resistant to IL-18BP decoy receptor inhibition by Britta Lipinski, Laura Unmuth, Paul Arras, Stefan Becker, Christina Bauer, Lars Toleikis, Simon Krah, Achim Doerner, Desislava Yanakieva, Ammelie Svea Boje, Katja Klausz, Matthias Peipp, Vanessa Siegmund, Andreas Evers, Harald Kolmar, Lukas Pekar, Stefan Zielonka

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Dual Fc optimization to increase the cytotoxic activity of a CD19-targeting antibody by Carina Lynn Gehlert, Pegah Rahmati, Ammelie Svea Boje, Dorothee Winterberg, Steffen Krohn, Thomas Theocharis, Elisa Cappuzzello, Anja Lux, Falk Nimmerjahn, Ralf J. Ludwig, Marta Lustig, Thies Rösner, Thomas Valerius, Denis Martin Schewe, Christian Kellner, Katja Klausz, Matthias Peipp

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Novel NKG2D-directed bispecific antibodies enhance antibody-mediated killing of malignant B cells by NK cells and T cells by Sebastian Lutz, Sebastian Lutz, Katja Klausz, Anca-Maria Albici, Lea Ebinger, Lea Sellmer, Hannah Teipel, André Frenzel, Anna Langner, Dorothee Winterberg, Steffen Krohn, Michael Hust, Michael Hust, Thomas Schirrmann, Stefan Dübel, Regina Scherließ, Andreas Humpe, Martin Gramatzki, Christian Kellner, Matthias Peipp

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Oncogenic KRAS Impairs EGFR Antibodies' Efficiency by C/EBPβ-Dependent Suppression of EGFR Expression by Stefanie Derer, Sven Berger, Martin Schlaeth, Tanja Schneider-Merck, Katja Klausz, Stefan Lohse, Marije B. Overdijk, Michael Dechant, Christian Kellner, Iris Nagelmeier, Andreas H. Scheel, Jeroen J. Lammerts van Bueren, Jan G.J. van de Winkel, Paul W.H.I. Parren, Matthias Peipp, Thomas Valerius

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