Structure- and machine learning-guided engineering demonstrate that a non-canonical disulfide in an anti-PD-1 rabbit antibody does not impede antibody developability by Wei-Ching Liang, Hongkang Xi, Dawei Sun, Luigi D’Ascenzo, Jonathan Zarzar, Nicole Stephens, Ryan Cook, Yinyin Li, Zhengmao Ye, Marissa Matsumoto, Jian Payandeh, Matthieu Masureel, Yan Wu

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Structure of the core human NADPH oxidase NOX2 by Sigrid Noreng, Naruhisa Ota, Yonglian Sun, Hoangdung Ho, Matthew Johnson, Christopher P. Arthur, Kellen Schneider, Isabelle Lehoux, Christopher W. Davies, Kyle Mortara, Kit Wong, Dhaya Seshasayee, Matthieu Masureel, Jian Payandeh, Tangsheng Yi, James T. Koerber

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1124 Discovery and evaluation of bicyclic peptides as modulators of pattern recognition receptors by Heather Scott, Katie Hill, Liuhong Chen, Kevin McDonnell, Philip Brandish, Nicholas Keen, Rachel Dodds, Laura L Goodfield, Robert P Hammer, Winston Lu, Tamera Ashworth, Hannah S Gardner, Luca Mascheroni, Tazmin Martin, Matthieu Masureel, Sandra Uhlenbroich, Marta Amaral, Julia Kristenson, Gemma E Mudd

Structural basis of antibody inhibition and chemokine activation of the human CC chemokine receptor 8 by Dawei Sun, Yonglian Sun, Eric Janezic, Tricia Zhou, Matthew Johnson, Caleigh Azumaya, Sigrid Noreng, Cecilia Chiu, Akiko Seki, Teresita L. Arenzana, John M. Nicoludis, Yongchang Shi, Baomei Wang, Hoangdung Ho, Prajakta Joshi, Christine Tam, Jian Payandeh, Laëtitia Comps-Agrar, Jianyong Wang, Sascha Rutz, James T. Koerber, Matthieu Masureel

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Exposing the molecular heterogeneity of glycosylated biotherapeutics by Luis F. Schachner, Christopher Mullen, Wilson Phung, Joshua D. Hinkle, Michelle Irwin Beardsley, Tracy Bentley, Peter Day, Christina Tsai, Siddharth Sukumaran, Tomasz Baginski, Danielle DiCara, Nicholas J. Agard, Matthieu Masureel, Joshua Gober, Adel M. ElSohly, Rafael Melani, John E. P. Syka, Romain Huguet, Michael T. Marty, Wendy Sandoval

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