Editorial: Risk factors in multiple myeloma identified before and during treatment: are we ready to personalize treatment? by Mattia D’Agostino, Carolina Terragna, Mark van Duin

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Monoclonal Antibodies to Treat Multiple Myeloma: A Dream Come True by Mattia D’Agostino, Salvatore Innorcia, Mario Boccadoro, Sara Bringhen

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Clinical Applications and Future Directions of Minimal Residual Disease Testing in Multiple Myeloma by Stefania Oliva, Mattia D'Agostino, Mario Boccadoro, Alessandra Larocca

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Promises and Pitfalls in the Use of PD-1/PD-L1 Inhibitors in Multiple Myeloma by Stefania Oliva, Rossella Troia, Mattia D'Agostino, Mario Boccadoro, Francesca Gay

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Normalization of the Immunological Microenvironment and Sustained Minimal Residual Disease Negativity: Do We Need Both for Long-Term Control of Multiple Myeloma? by Giuseppe Bertuglia, Lorenzo Cani, Alessandra Larocca, Francesca Gay, Mattia D’Agostino

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The Role of Monoclonal Antibodies in the First-Line Treatment of Transplant-Ineligible Patients with Newly Diagnosed Multiple Myeloma by Francesca Bonello, Mariella Grasso, Mattia D’Agostino, Ivana Celeghini, Alessia Castellino, Mario Boccadoro, Sara Bringhen

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Structural–Functional Relationship of the Ribonucleolytic Activity of aIF5A from <i>Sulfolobus solfataricus</i> by Alice Romagnoli, Paolo Moretti, Mattia D’Agostino, Jesmina Rexha, Nunzio Perta, Astra Piccinini, Daniele Di Marino, Francesco Spinozzi, Anna La Teana

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Insights Into the Binding Mechanism of GC7 to Deoxyhypusine Synthase in Sulfolobus solfataricus: A Thermophilic Model for the Design of New Hypusination Inhibitors by Mattia D'Agostino, Stefano Motta, Alice Romagnoli, Alice Romagnoli, Patrick Orlando, Luca Tiano, Anna La Teana, Anna La Teana, Daniele Di Marino, Daniele Di Marino

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Immune dysfunctions affecting bone marrow Vγ9Vδ2 T cells in multiple myeloma: Role of immune checkpoints and disease status by Claudia Giannotta, Barbara Castella, Barbara Castella, Ezio Tripoli, Ezio Tripoli, Daniele Grimaldi, Ilaria Avonto, Mattia D’Agostino, Alessandra Larocca, Joanna Kopecka, Mariella Grasso, Chiara Riganti, Massimo Massaia, Massimo Massaia

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P678: EARLY WARNING RESPONSES IN CML PATIENTS: A REAL-LIFE TURIN EXPERIENCE by Valentina Giai, Matteo Bisio, Tiziana Rosso, Irene Urbino, Chiara Frairia, Matteo Olivi, Giuseppe Lanzarone, Mattia D’agostino, Eloise Beggiato, Stefano D’ ardia, Ernesta Audisio, Marco Cerrano, Dario Ferrero, Patrizia Pregno, Roberto Freilone

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P895: DARATUMUMAB PLUS POMALIDOMIDE AND DEXAMETHASONE (DPD) IN PATIENTS WITH RELAPSED/REFRACTORY MULTIPLE MYELOMA AND 17P DELETION: UPDATED ANALYSIS OF THE DEDALO PHASE II TRIAL by Vittorio Montefusco, Anna Maria Cafro, Gloria Margiotta-Casaluci, Francesca Patriarca, Roberto Mina, Mattia D’agostino5, Anna Benedetta Dalla Palma, Rita Rizzi, Angelo Genua, Francesca Fazio, Laura Paris, Angelo Belotti, Ilaria Rizzello, Concetta Conticello, Carmelo Carlo-Stella, Mario Boccadoro

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P968: ALLOCATION AND VALIDATION OF THE SECOND REVISION OF THE INTERNATIONAL STAGING SYSTEM IN THE ICARIA-MM AND IKEMA STUDIES by Aurore Perrot, Paul Richardson, Joseph Mikhael, Thomas G. Martin, Meral Beksac, Ivan Spicka, Marcelo Eduardo Capra, Mattia D’agostino, Pieter Sonneveld, Kamlesh Bisht, Taro Fukao, Rick Zhang, Keisuke Tada, Christina Tekle, Sandrine Macé, Zandra Klippel, Helgi van de Velde, Philippe Moreau

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Lysin (K)-specific demethylase 1 inhibition enhances proteasome inhibitor response and overcomes drug resistance in multiple myeloma by Cecilia Bandini, Elisabetta Mereu, Tina Paradzik, Maria Labrador, Monica Maccagno, Michela Cumerlato, Federico Oreglia, Lorenzo Prever, Veronica Manicardi, Elisa Taiana, Domenica Ronchetti, Mattia D’Agostino, Francesca Gay, Alessandra Larocca, Lenka Besse, Giorgio Roberto Merlo, Emilio Hirsch, Alessia Ciarrocchi, Giorgio Inghirami, Antonino Neri, Roberto Piva

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P804: PLASMA CELL LEUKEMIA-LIKE TRANSCRIPTOME OF BONE MARROW PLASMA CELLS AND CIRCULATING TUMOR CELL LEVELS IN PERIPHERAL BLOOD COMPLEMENTARILY DEFINE HIGH-RISK IN NEWLY DIAGNOSED... by Mattia D’agostino, Davine Hofste Op Bruinink, Mark van Duin, Delia Rota-Scalabrini, Luca Bertamini, Rowan Kuiper, Angelo Belotti, Vincenzo Marasco, Stefania Oliva, Elena Rivolti, Jennifer Rogers, Roberto Mina, Mariella Grasso, Antonio Ledda, Massimo Offidani, Monica Galli, Michele Cavo, Annemiek Broijl, Pellegrino Musto, Benedetto Bruno, Mario Boccadoro, Pieter Sonneveld, Francesca Gay

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Octogenarian newly diagnosed multiple myeloma patients without geriatric impairments: the role of age >80 in the IMWG frailty score by Mattia D’Agostino, Alessandra Larocca, Massimo Offidani, Anna Marina Liberati, Gianluca Gaidano, Maria Teresa Petrucci, Daniele Derudas, Andrea Capra, Renato Zambello, Nicola Cascavilla, Paolo de Fabritiis, Vanessa Innao, Francesca Bonello, Francesca Patriarca, Giulia Benevolo, Nicola Giuliani, Gabriele Aitoro, Tommasina Guglielmelli, Francesco Di Raimondo, Paolo Corradini, Pellegrino Musto, Roman Hájek, Pieter Sonneveld, Mario Boccadoro, Sara Bringhen

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P1680: HEALTH-RELATED QUALITY OF LIFE IN TRANSPLANT-INELIGIBLE REAL-LIFE MULTIPLE MYELOMA PATIENTS TREATED WITH FIXED-DURATION BORTEZOMIB-MELPHALAN-PREDNISONE VS. CONTINUOUS LENALI... by Mattia D’agostino, Sara Bringhen, Nicola Giuliani, Elisabetta Antonioli, Renato Zambello, Francesco Cattel, Roberto Ria, Alessandro Allegra, Giovanna Leonardi, Angelo Belotti, Piero Galieni, Gloria Margiotta-Casaluci, Maria Cantonetti, Valentina Cotugno, Barbara Gamberi, Fabrizio Pane, Anna Marina Liberati, Patrizia Tosi, Maide Maria Cavalli, Donato Mannina, Giulia Benevolo, Silvia Mangiacavalli, Andrea Evangelista, Giovannino Ciccone, Mario Boccadoro, Benedetto Bruno, Alessandra Larocca

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Minimal residual disease assessment by multiparameter flow cytometry in transplant-eligible myeloma in the EMN02/HOVON 95 MM trial by Stefania Oliva, Davine Hofste op Bruinink, Lucie Rihova, Mattia D’Agostino, Lucia Pantani, Andrea Capra, Bronno van der Holt, Rossella Troia, Maria Teresa Petrucci, Tania Villanova, Pavla Vsianska, Romana Jugooa, Claudia Brandt-Hagens, Milena Gilestro, Massimo Offidani, Rossella Ribolla, Monica Galli, Roman Hajek, Francesca Gay, Michele Cavo, Paola Omedé, Vincent H. J. van der Velden, Mario Boccadoro, Pieter Sonneveld

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