Conclusions of the SIGNAL study in Huntington and implications for treatment of other slowly progressive neurodegenerative diseases by Maurice Zauderer, Elizabeth Erin Evans

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434 Phase 1/2 study to evaluate pepinemab in combination with pembrolizumab in advanced, recurrent or metastatic head and neck cancer (KEYNOTE B84) by Elizabeth Evans, Crystal Mallow, Ernest Smith, Maurice Zauderer, Marya Chaney, Terrence Fisher, Amber Foster, John Leonard

Anti-Semaphorin 4D Rescues Motor, Cognitive, and Respiratory Phenotypes in a Rett Syndrome Mouse Model by Yilin Mao, Elizabeth E. Evans, Vikas Mishra, Leslie Balch, Allison Eberhardt, Maurice Zauderer, Wendy A. Gold

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A Vaccinia-based system for directed evolution of GPCRs in mammalian cells by Christoph Klenk, Maria Scrivens, Anina Niederer, Shuying Shi, Loretta Mueller, Elaine Gersz, Maurice Zauderer, Ernest S. Smith, Ralf Strohner, Andreas Plückthun

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Semaphorin 4D is upregulated in neurons of diseased brains and triggers astrocyte reactivity by Elizabeth E. Evans, Vikas Mishra, Crystal Mallow, Elaine M. Gersz, Leslie Balch, Alan Howell, Christine Reilly, Ernest S. Smith, Terrence L. Fisher, Maurice Zauderer

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676 Pepinemab, a semaphorin 4D inhibitor, in combination with pembrolizumab induced formation of organized lymphoid aggregates in phase 1b/2 study for first-line treatment of R/M H... by Elizabeth Evans, Nagashree Seetharamu, Crystal Mallow, Maurice Zauderer, Barbara Burtness, Marya Chaney, Alexander Spira, Conor Steuer, Tarek Mekhail, J Thaddeus Beck, Douglas Adkins, Terrence Fisher, Amber Foster, John Leonard, Nabil F Saba, Megan Baumgart, Steven Hager, Christopher Chay

629 Neoadjuvant SEMA4D inhibitor pepinemab combination with nivolumab increases crosstalk between B cell and CD26hi T cell in patients with resectable stage III melanoma by Brian Burns, Elizabeth Evans, Ragini Kudchadkar, Crystal Mallow, Christine Reilly, Maurice Zauderer, Gregory B Lesinski, Keith A Delman, Chrystal M Paulos, Brian Olson, Terrence Fisher, Jayden Kim, Michael C Lowe, Ayana T Ruffin, Jacklyn Hammons, Agnes Harutyunyan, Melinda Yushak, Ali Mokhtari, Douglas Parker

SEMA4D compromises blood–brain barrier, activates microglia, and inhibits remyelination in neurodegenerative disease by Ernest S. Smith, Alan Jonason, Christine Reilly, Janaki Veeraraghavan, Terrence Fisher, Michael Doherty, Ekaterina Klimatcheva, Crystal Mallow, Chad Cornelius, John E. Leonard, Nicola Marchi, Damir Janigro, Azeb Tadesse Argaw, Trinh Pham, Jennifer Seils, Holm Bussler, Sebold Torno, Renee Kirk, Alan Howell, Elizabeth E. Evans, Mark Paris, William J. Bowers, Gareth John, Maurice Zauderer

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Use of poxvirus display to select antibodies specific for complex membrane antigens by Ernest S. Smith, Leslie A. Balch, Maria Scrivens, Shuying Shi, Wei Wang, Caroline D. Harvey, Angelica A. Cornelison, Malgorzata Gil-Moore, Renee A. Kirk, Loretta L. Mueller, Richard L. Hall, Alan P. Howell, Christine A. Reilly, Jessica M. Mayer, Francis G. Murante, Kari A Viggiani, Elaine M. Gersz, Holm Bussler, Madeleine R. Keefe, Elizabeth E. Evans, Mark J. Paris, Maurice Zauderer

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