FANCD2 limits replication stress and genome instability in cells lacking BRCA2. by Michl, J, Zimmer, J, Buffa, F, McDermott, U, Tarsounas, M

Combinations of PARP inhibitors with temozolomide drive PARP1 trapping and apoptosis in Ewing’s sarcoma by Gill, S, Travers, J, Pshenichnaya, I, Kogera, F, Barthorpe, S, Mironenko, T, Richardson, L, Benes, C, Stratton, M, McDermott, U, Jackson, S, Garnett, M

Targeting acid ceramidase to improve the radiosensitivity of rectal cancer by Clifford, R, Govindarajah, N, Bowden, D, Sutton, P, Glenn, M, Darvish-Damavandi, M, Buczacki, S, McDermott, U, Szulc, Z, Ogretmen, B, Parsons, J, Vimalachandran, D

Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma. by Müller, J, Krijgsman, O, Tsoi, J, Robert, L, Hugo, W, Song, C, Kong, X, Possik, P, Cornelissen-Steijger, P, Foppen, M, Kemper, K, Goding, C, McDermott, U, Blank, C, Haanen, J, Graeber, T, Ribas, A, Lo, R, Peeper, D

In-depth clinical and biological exploration of DNA damage immune response as a biomarker for oxaliplatin use in colorectal cancer by Malla, SB, Fisher, DJ, Domingo, E, Blake, A, Hassanieh, S, Redmond, KL, Richman, SD, Youdell, M, Walker, SM, Logan, GE, Chatzipli, A, Amirkhah, R, Humphries, MP, Craig, SG, McDermott, U, Seymour, MT, Morton, DG, Quirke, P, West, NP, Salto-Tellez, M, Kennedy, RD, Johnston, PG, Tomlinson, I, Koelzer, VH, Campo, L, Kaplan, RS, Longley, DB, Lawler, M, Maughan, TS, Brown, LC, Dunne, PD

Mutational signatures of ionizing radiation in second malignancies by Behjati, S, Gundem, G, Wedge, DC, Roberts, ND, Tarpey, PS, Cooke, SL, Van Loo, P, Alexandrov, LB, Ramakrishna, M, Davies, H, Nik-Zainal, S, Hardy, C, Latimer, C, Raine, KM, Stebbings, L, Menzies, A, Jones, D, Shepherd, R, Butler, AP, Teague, JW, Jorgensen, M, Khatri, B, Pillay, N, Shlien, A, Futreal, PA, Badie, C, McDermott, U, Bova, GS, Richardson, AL, Flanagan, AM, Stratton, MR, Campbell, PJ

Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma. by Behjati, S, Tarpey, PS, Haase, K, Ye, H, Young, MD, Alexandrov, LB, Farndon, SJ, Collord, G, Wedge, DC, Martincorena, I, Cooke, SL, Davies, H, Mifsud, W, Lidgren, M, Martin, S, Latimer, C, Maddison, M, Butler, AP, Teague, JW, Pillay, N, Shlien, A, McDermott, U, Futreal, PA, Baumhoer, D, Zaikova, O, Bjerkehagen, B, Myklebost, O, Amary, MF, Tirabosco, R, Van Loo, P, Stratton, MR, Flanagan, AM, Campbell, PJ

Characterizing mutational signatures in human cancer cell lines reveals episodic APOBEC mutagenesis by Petljak, M, Alexandrov, LB, Brammeld, JS, Price, S, Wedge, DC, Grossmann, S, Dawson, KJ, Ju, YS, Iorio, F, Tubio, JMC, Koh, CC, Georgakopoulos-Soares, I, Rodríguez-Martín, B, Otlu, B, O'Meara, S, Butler, AP, Menzies, A, Bhosle, SG, Raine, K, Jones, DR, Teague, JW, Beal, K, Latimer, C, O'Neill, L, Zamora, J, Anderson, E, Patel, N, Maddison, M, Ng, BL, Graham, J, Garnett, MJ, McDermott, U, Nik-Zainal, S, Campbell, PJ, Stratton, MR

Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer by Ju, Y, Alexandrov, L, Gerstung, M, Martincorena, I, Nik-Zainal, S, Ramakrishna, M, Davies, H, Papaemmanuil, E, Gundem, G, Shlien, A, Bolli, N, Behjati, S, Tarpey, P, Nangalia, J, Massie, C, Butler, A, Teague, J, Vassiliou, G, Green, A, Du, M, Unnikrishnan, A, Pimanda, J, Teh, B, Munshi, N, Greaves, M, Vyas, P, El-Naggar, A, Santarius, T, Collins, V, Grundy, R, Taylor, J, Hayes, D, Malkin, D, Foster, C, Warren, A, Whitaker, H, Brewer, D, Eeles, R, Cooper, C, Neal, D, Visakorpi, T, Isaacs, W, Bova, G, Flanagan, A, Futreal, P, Lynch, A, Chinnery, P, McDermott, U, Stratton, MR, Campbell, P

Systematic identification of genomic markers of drug sensitivity in cancer cells by Garnett, MJ, Edelman, EJ, Heidorn, SJ, Greenman, CD, Dastur, A, Lau, KW, Greninger, P, Thompson, IR, Luo, X, Soares, J, Liu, Q, Iorio, F, Surdez, D, Chen, L, Milano, RJ, Bignell, GR, Tam, AT, Davies, H, Stevenson, JA, Barthorpe, S, Lutz, SR, Lawrence, K, Haber, DA, McLaren-Douglas, A, Mitropoulos, X, Mironenko, T, Thi, H, Richardson, L, Zhou, W, Jewitt, F, Zhang, T, O'Brien, P, Boisvert, JL, Price, S, Hur, W, Yang, W, Deng, X, Butler, A, Choi, HG, Chang, JW, Baselga, J, Stamenkovic, I, Engelman, JA, Sharma, SV, Delattre, O, Saez-Rodriguez, J, Gray, NS, Settleman, J, Futreal, PA, Ramaswamy, S, Stratton, MR, McDermott, U, Benes, CH

Appraising the relevance of DNA copy number loss and gain in prostate cancer using whole genome DNA sequence data by Camacho, N, Van Loo, P, Edwards, S, Kay, J, Matthews, L, Haase, K, Clark, J, Dennis, N, Thomas, S, Kremeyer, B, Zamora, J, Butler, A, Gundem, G, Merson, S, Luxton, H, Hawkins, S, Ghori, M, Marsden, L, Lambert, A, Karaszi, K, Pelvender, G, Massie, C, Kote-Jarai, Z, Raine, K, Jones, D, Howat, W, Hazell, S, Livni, N, Fisher, C, Ogden, C, Kumar, P, Thompson, A, Nicol, D, Mayer, E, Dudderidge, T, Yu, Y, Zhang, H, Shah, N, Gnanapragasam, V, Isaacs, W, Visakorpi, T, Hamdy, F, Berney, D, Verrill, C, Warren, A, Wedge, D, Lynch, A, Foster, C, Lu, Y, Bova, G, Whitaker, H, McDermott, U, Neal, D, Eeles, R, Cooper, C, Brewer, D

Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets by Wedge, D, Gundem, G, Mitchell, T, Woodcock, D, Martincorena, I, Ghori, M, Zamora, J, Butler, A, Whitaker, H, Kote-Jarai, Z, Alexandrov, L, Van Loo, P, Massie, C, Dentro, S, Warren, A, Verrill, C, Berney, D, Dennis, N, Merson, S, Hawkins, S, Howat, W, Lu, Y, Lambert, A, Kay, J, Kremeyer, B, Karaszi, K, Luxton, H, Camacho, N, Marsden, L, Edwards, S, Matthews, L, Bo, V, Leongamornlert, D, McLaren, S, Ng, A, Yu, Y, Zhang, H, Dadaev, T, Thomas, S, Easton, D, Ahmed, M, Bancroft, E, Fisher, C, Livni, N, Nicol, D, Tavaré, S, Gill, P, Greenman, C, Khoo, V, Van As, N, Kumar, P, Ogden, C, Cahill, D, Thompson, A, Mayer, E, Rowe, E, Dudderidge, T, Gnanapragasam, V, Shah, N, Raine, K, Jones, D, Menzies, A, Stebbings, L, Teague, J, Hazell, S, Corbishley, C, de Bono, J, Attard, G, Isaacs, W, Visakorpi, T, Fraser, M, Boutros, P, Bristow, R, Workman, P, Sander, C, Hamdy, F, Futreal, A, McDermott, U, Al-Lazikani, B, Lynch, A, Bova, G, Foster, C, Brewer, D, Neal, D, Cooper, C, Eeles, R