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MLL-rearranged acute lymphoblastic leukemias activate BCL-2 through H3K79 methylation and are sensitive to the BCL-2-specific antagonist ABT-199 by Benito, J, Godfrey, L, Kojima, K, Hogdal, L, Wunderlich, M, Geng, H, Marzo, I, Harutyunyan, K, Golfman, L, North, P, Kerry, J, Ballabio, E, Chonghaile, T, Gonzalo, O, Qiu, Y, Jeremias, I, Debose, L, O'Brien, E, Ma, H, Zhou, P, Jacamo, R, Park, E, Coombes, K, Zhang, N, Thomas, D, O'Brien, S, Kantarjian, H, Leverson, J, Kornblau, S, Andreeff, M, Müschen, M, Zweidler-McKay, P, Mulloy, J, Letai, A, Milne, T, Konopleva, M

Are large clinical trials in orthopaedic trauma justified? by Sprague, S, Tornetta, P, Slobogean, GP, O'Hara, NN, McKay, P, Petrisor, B, Jeray, KJ, Schemitsch, EH, Sanders, D, Bhandari, M, Guyatt, GH, Walter, S, Anglen, J, Bosse, M, Liew, S, Sancheti, P, Tai, K, Heels-Ansdell, D, Buckingham, L, Duraikannan, A, Tanner, SL, Snider, RG, Altman, D, Gandhi, R, Bischoff, M, Della Rocca, GJ, Ristevski, B, Rajaratnam, K, Williams, D, Denkers, M, Bednar, D, Sadler, J, Kwok, D, Drew, B, Wong, I, Madden, K, Hall, JA, McKee, MD, Ahn, H, Whelan, D, Waddell, J, Daniels, T, Bogoch, E, Nauth, A, Vicente, MR, Hidy, JT, Lawendy, AR, Gurr, K, Carey, T, Bailey, C, MacLeod, M, Bartley, D, Tieszer, C, Coles, C, Leighton, R, Richardson, CG, Biddulph, M, Gross, M, Dunbar, M, Amirault, JD, Alexander, D, Coady, C, Glazebrook, M, Johnston, D, Oxner, W, Trenholm, JA, Reardon, G, Trask, K, MacDonald, S, Papp, S, Gofton, W, Liew, A, Kingwell, S, O'Neill, J, Johnson, G, Wai, E, Foxall, J, Broekhuyse, HM, O'Brien, PJ, Blachut, PA, Lefaivre, KA, Johal, R, Leduc, S, Laflamme, GY, Beaumont, P, Malo, M, Benoit, B, Rouleau, D, Ranger, P, Fournier, J, Tardif, K, Reindl, R