Peptide Variant Detection by a Living Yeast Biosensor via an Epitope-Selective Protease by Tea Crnković, Benjamin J. Bokor, Mead E. Lockwood, Virginia W. Cornish

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Halting of caspase activity protects tau from MC1-conformational change and aggregation by Mead, E, Kestoras, D, Gibson, Y, Hamilton, L, Goodson, R, Jones, S, Eversden, S, Davies, P, O’Neill, M, Hutton, M, Szekeres, P, Wolak, J

TREM2 Alzheimer’s variant R47H causes similar transcriptional dysregulation to knockout, yet only subtle functional phenotypes in human iPSC-derived macrophages by Hall-Roberts, H, Di Daniel, E, Agarwal, D, Obst, J, Smith, TB, Monzón-Sandoval, J, Webber, C, James, WS, Mead, E, Davis, JB, Cowley, SA

Discovery of N-methylpiperazinyl flavones as a novel class of compounds with therapeutic potential against Alzheimer’s disease: synthesis, binding affinity towards amyloid β oligom... by Matos, A, Man, T, Idrissi, I, Souza, C, Mead, E, Dunbar, C, Wolak, J, Olivera, M, Evans, D, Grayson, J, Partridge, B, Garwood, C, Ning, K, Sharman, G, Chen, B, Rauter, A

Structural dynamics of the ubiquitin specific protease UPS30 in complex with a cyanopyrrolidine-containing covalent inhibitor by O’Brien, DP, Jones, HBL, Shi, Y, Guenther, F, Vendrell, I, Viner, R, Brennan, PE, Mead, E, Zarganes-Tzitzikas, T, Davis, JB, Pinto-Fernández, A, England, KS, Murphy, EJ, Turnbull, AP, Kessler, BM

Selection and structural characterization of anti-TREM2 scFvs that reduce levels of shed ectodomain by Szykowska, A, Chen, Y, Smith, TB, Preger, C, Yang, J, Qian, D, Mukhopadhyay, SM, Wigren, E, Neame, SJ, Gräslund, S, Persson, H, Atkinson, PJ, Di Daniel, E, Mead, E, Wang, J, Davis, JB, Burgess-Brown, NA, Bullock, AN