CD20 positive cells are undetectable in the majority of multiple myeloma cell lines and are not associated with a cancer stem cell phenotype by Teresa Paíno, Enrique M. Ocio, Bruno Paiva, Laura San-Segundo, Mercedes Garayoa, Norma C. Gutiérrez, M. Eugenia Sarasquete, Atanasio Pandiella, Alberto Orfao, Jesús F. San Miguel

Get full text

The effect of the proteasome inhibitor bortezomib on acute myeloid leukemia cells and drug resistance associated with the CD34+ immature phenotype by Enrique Colado, Stela Álvarez-Fernández, Patricia Maiso, Jesús Martín-Sánchez, Maria Belén Vidriales, Mercedes Garayoa, Enrique M. Ocio, Juan Carlos Montero, Atanasio Pandiella, Jesús F. San Miguel

Get full text

Phenotypic, genomic and functional characterization reveals no differences between CD138++ and CD138low subpopulations in multiple myeloma cell lines. by Teresa Paíno, María E Sarasquete, Bruno Paiva, Patryk Krzeminski, Laura San-Segundo, Luis A Corchete, Alba Redondo, Mercedes Garayoa, Ramón García-Sanz, Norma C Gutiérrez, Enrique M Ocio, Jesús F San-Miguel

Get full text

In vitro and in vivo rationale for the triple combination of panobinostat (LBH589) and dexamethasone with either bortezomib or lenalidomide in multiple myeloma by Enrique M. Ocio, David Vilanova, Peter Atadja, Patricia Maiso, Edvan Crusoe, Diego Fernández-Lázaro, Mercedes Garayoa, Laura San-Segundo, Teresa Hernández-Iglesias, Enrique de Álava, Wenlin Shao, Yung-Mae Yao, Atanasio Pandiella, Jesús F. San-Miguel

Get full text

Synergistic DNA-damaging effect in multiple myeloma with the combination of zalypsis, bortezomib and dexamethasone by Ana-Alicia López-Iglesias, Lorena González-Méndez, Laura San-Segundo, Ana B. Herrero, Susana Hernández-García, Montserrat Martín-Sánchez, Norma C. Gutiérrez, Teresa Paíno, Pablo Avilés, María-Victoria Mateos, Jesús F. San-Miguel, Mercedes Garayoa, Enrique M. Ocio

Get full text

Dasatinib as a bone-modifying agent: anabolic and anti-resorptive effects. by Antonio Garcia-Gomez, Enrique M Ocio, Edvan Crusoe, Carlos Santamaria, Pilar Hernández-Campo, Juan F Blanco, Fermin M Sanchez-Guijo, Teresa Hernández-Iglesias, Jesús G Briñón, Rosa M Fisac-Herrero, Francis Y Lee, Atanasio Pandiella, Jesús F San Miguel, Mercedes Garayoa

Get full text

Stroma-Mediated Resistance to S63845 and Venetoclax through MCL-1 and BCL-2 Expression Changes Induced by miR-193b-3p and miR-21-5p Dysregulation in Multiple Myeloma by Esperanza M. Algarín, Dalia Quwaider, Francisco J. Campos-Laborie, Andrea Díaz-Tejedor, Pedro Mogollón, Elena Vuelta, Montserrat Martín-Sánchez, Laura San-Segundo, Lorena González-Méndez, Norma C. Gutiérrez, Ramón García-Sanz, Teresa Paíno, Javier De Las Rivas, Enrique M. Ocio, Mercedes Garayoa

Get full text

Zalypsis has in vitro activity in acute myeloid blasts and leukemic progenitor cells through the induction of a DNA damage response by Enrique Colado, Teresa Paíno, Patricia Maiso, Enrique M. Ocio, Xi Chen, Stela Álvarez-Fernández, Norma C. Gutiérrez, Jesús Martín-Sánchez, Juan Flores-Montero, Laura San Segundo, Mercedes Garayoa, Diego Fernández-Lázaro, Maria-Belen Vidriales, Carlos M. Galmarini, Pablo Avilés, Carmen Cuevas, Atanasio Pandiella, Jesús F. San-Miguel

Get full text

The kinesin spindle protein inhibitor filanesib enhances the activity of pomalidomide and dexamethasone in multiple myeloma by Susana Hernández-García, Laura San-Segundo, Lorena González-Méndez, Luis A. Corchete, Irena Misiewicz-Krzeminska, Montserrat Martín-Sánchez, Ana-Alicia López-Iglesias, Esperanza Macarena Algarín, Pedro Mogollón, Andrea Díaz-Tejedor, Teresa Paíno, Brian Tunquist, María-Victoria Mateos, Norma C Gutiérrez, Elena Díaz-Rodriguez, Mercedes Garayoa, Enrique M Ocio

Get full text

Preclinical evaluation of the simultaneous inhibition of MCL-1 and BCL-2 with the combination of S63845 and venetoclax in multiple myeloma by Esperanza M Algarín, Andrea Díaz-Tejedor, Pedro Mogollón, Susana Hernández-García, Luis A. Corchete, Laura San-Segundo, Montserrat Martín-Sánchez, Lorena González-Méndez, Marie Schoumacher, Sebastien Banquet, Laurence Kraus-Berthier, Ioana Kloos, Alix Derreal, Ensar Halilovic, Heiko Maacke, Norma C. Gutiérrez, María-Victoria Mateos, Teresa Paíno, Mercedes Garayoa, Enrique M. Ocio

Get full text

Targeting aberrant DNA methylation in mesenchymal stromal cells as a treatment for myeloma bone disease by Antonio Garcia-Gomez, Tianlu Li, Carlos de la Calle-Fabregat, Javier Rodríguez-Ubreva, Laura Ciudad, Francesc Català-Moll, Gerard Godoy-Tena, Montserrat Martín-Sánchez, Laura San-Segundo, Sandra Muntión, Xabier Morales, Carlos Ortiz-de-Solórzano, Julen Oyarzabal, Edurne San José-Enériz, Manel Esteller, Xabier Agirre, Felipe Prosper, Mercedes Garayoa, Esteban Ballestar

Get full text

Preclinical anti-myeloma activity of EDO-S101, a new bendamustine-derived molecule with added HDACi activity, through potent DNA damage induction and impairment of DNA repair by Ana-Alicia López-Iglesias, Ana B. Herrero, Marta Chesi, Laura San-Segundo, Lorena González-Méndez, Susana Hernández-García, Irena Misiewicz-Krzeminska, Dalia Quwaider, Montserrat Martín-Sánchez, Daniel Primo, Teresa Paíno, P. Leif Bergsagel, Thomas Mehrling, Marcos González-Díaz, Jesús F. San-Miguel, María-Victoria Mateos, Norma C. Gutiérrez, Mercedes Garayoa, Enrique M. Ocio

Get full text