Michael B. Yaffe

Michael B. Yaffe is an American scientist, professor, surgeon, and retired U.S. Army Reserve Medical Corps Colonel. He is currently the David H. Koch Professor of Biology & Biological Engineering at MIT and a trauma surgeon at the Beth Israel Deaconess Medical Center. In 2016, the United States Army awarded him the Bronze Star Medal for his services as a trauma surgeon on active duty in Afghanistan. He also treated many of the victims of the Boston Marathon bombing. Provided by Wikipedia
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  1. 1
    MAPKAP Kinase-2 phosphorylation of PABPC1 controls its interaction with 14-3-3 proteins after DNA damage: A combined kinase and protein array approach

    MAPKAP Kinase-2 phosphorylation of PABPC1 controls its interaction with 14-3-3 proteins after DNA damage: A combined kinase and protein array approach by Justine R. Stehn, Scott R. Floyd, Erik W. Wilker, H. Christian Reinhardt, Scott M. Clarke, Qiuying Huang, Roberto D. Polakiewicz, Nahum Sonenberg, Yi Wen Kong, Yi Wen Kong, Michael B. Yaffe, Michael B. Yaffe, Michael B. Yaffe, Michael B. Yaffe, Michael B. Yaffe, Michael B. Yaffe

    Published 2023-04-01
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  2. 2
    Are redox changes a critical switch for mitotic progression?

    Are redox changes a critical switch for mitotic progression? by Daniel C. Lim, Vladimir Joukov, Michael B. Yaffe

    Published 2020-11-01
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  3. 3
    Inducing DNA damage through R-loops to kill cancer cells

    Inducing DNA damage through R-loops to kill cancer cells by Fred C. Lam, Yi Wen Kong, Michael B. Yaffe

    Published 2021-01-01
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  4. 4
    Multi-pathway DNA-repair reporters reveal competition between end-joining, single-strand annealing and homologous recombination at Cas9-induced DNA double-strand breaks

    Multi-pathway DNA-repair reporters reveal competition between end-joining, single-strand annealing and homologous recombination at Cas9-induced DNA double-strand breaks by Bert van de Kooij, Alex Kruswick, Haico van Attikum, Michael B. Yaffe

    Published 2022-09-01
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  5. 5
    Immunogenic cell stress and injury versus immunogenic cell death: implications for improving cancer treatment with immune checkpoint blockade

    Immunogenic cell stress and injury versus immunogenic cell death: implications for improving cancer treatment with immune checkpoint blockade by Ganapathy Sriram, Tiffany R. Emmons, Lauren E. Milling, Darrell J. Irvine, Michael B. Yaffe

    Published 2022-12-01
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  6. 6
    Combined experimental and computational analysis of DNA damage signaling reveals context‐dependent roles for Erk in apoptosis and G1/S arrest after genotoxic stress

    Combined experimental and computational analysis of DNA damage signaling reveals context‐dependent roles for Erk in apoptosis and G1/S arrest after genotoxic stress by Andrea R Tentner, Michael J Lee, Gerry J Ostheimer, Leona D Samson, Douglas A Lauffenburger, Michael B Yaffe

    Published 2012-01-01
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  7. 7
    Activation of GPR3-β-arrestin2-PKM2 pathway in Kupffer cells stimulates glycolysis and inhibits obesity and liver pathogenesis

    Activation of GPR3-β-arrestin2-PKM2 pathway in Kupffer cells stimulates glycolysis and inhibits obesity and liver pathogenesis by Ting Dong, Guangan Hu, Zhongqi Fan, Huirui Wang, Yinghui Gao, Sisi Wang, Hao Xu, Michael B. Yaffe, Matthew G. Vander Heiden, Guoyue Lv, Jianzhu Chen

    Published 2024-01-01
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  8. 8
    Study of alteplase for respiratory failure in severe acute respiratory syndrome coronavirus 2/COVID‐19: Study design of the phase IIa STARS trial

    Study of alteplase for respiratory failure in severe acute respiratory syndrome coronavirus 2/COVID‐19: Study design of the phase IIa STARS trial by Hunter B. Moore, Christopher D. Barrett, Ernest E. Moore, Rashi Jhunjhunwala, Robert C. McIntyre, Peter K Moore, Janice Wang, Negin Hajizadeh, Daniel S. Talmor, Angela Sauaia, Michael B. Yaffe

    Published 2020-08-01
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  9. 9
    Comprehensive substrate specificity profiling of the human Nek kinome reveals unexpected signaling outputs

    Comprehensive substrate specificity profiling of the human Nek kinome reveals unexpected signaling outputs by Bert van de Kooij, Pau Creixell, Anne van Vlimmeren, Brian A Joughin, Chad J Miller, Nasir Haider, Craig D Simpson, Rune Linding, Vuk Stambolic, Benjamin E Turk, Michael B Yaffe

    Published 2019-05-01
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  10. 10
    Comprehensive profiling of the STE20 kinase family defines features essential for selective substrate targeting and signaling output.

    Comprehensive profiling of the STE20 kinase family defines features essential for selective substrate targeting and signaling output. by Chad J Miller, Hua Jane Lou, Craig Simpson, Bert van de Kooij, Byung Hak Ha, Oriana S Fisher, Natasha L Pirman, Titus J Boggon, Jesse Rinehart, Michael B Yaffe, Rune Linding, Benjamin E Turk

    Published 2019-03-01
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  11. 11
    Fibrinolytic therapy for refractory COVID‐19 acute respiratory distress syndrome: Scientific rationale and review

    Fibrinolytic therapy for refractory COVID‐19 acute respiratory distress syndrome: Scientific rationale and review by Christopher D. Barrett, Hunter B. Moore, Ernest E. Moore, Robert C. McIntyre, Peter K. Moore, John Burke, Fei Hua, Joshua Apgar, Daniel S. Talmor, Angela Sauaia, Deborah R. Liptzin, Livia A. Veress, Michael B. Yaffe

    Published 2020-05-01
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  12. 12
    The Fanconi anemia core complex promotes CtIP-dependent end resection to drive homologous recombination at DNA double-strand breaks

    The Fanconi anemia core complex promotes CtIP-dependent end resection to drive homologous recombination at DNA double-strand breaks by Bert van de Kooij, Fenna J. van der Wal, Magdalena B. Rother, Wouter W. Wiegant, Pau Creixell, Merula Stout, Brian A. Joughin, Julia Vornberger, Matthias Altmeyer, Marcel A. T. M. van Vugt, Michael B. Yaffe, Haico van Attikum

    Published 2024-08-01
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  13. 13
    A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint.

    A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint. by Marcel A T M van Vugt, Alexandra K Gardino, Rune Linding, Gerard J Ostheimer, H Christian Reinhardt, Shao-En Ong, Chris S Tan, Hua Miao, Susan M Keezer, Jeijin Li, Tony Pawson, Timothy A Lewis, Steven A Carr, Stephen J Smerdon, Thijn R Brummelkamp, Michael B Yaffe

    Published 2010-01-01
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  14. 14
    Proteomics of Coagulopathy Following Injury Reveals Limitations of Using Laboratory Assessment to Define Trauma-Induced Coagulopathy to Predict Massive Transfusion

    Proteomics of Coagulopathy Following Injury Reveals Limitations of Using Laboratory Assessment to Define Trauma-Induced Coagulopathy to Predict Massive Transfusion by Hunter B. Moore, MD, PhD, Matthew D. Neal, MD, Marnie Bertolet, PhD, Brian A. Joughin, PhD, Michael B. Yaffe, MD, PhD, Christopher D. Barrett, MD, Molly A. Bird, BS, Russell P. Tracy, PhD, Ernest E Moore, MD, Jason L. Sperry, MD, Brian S. Zuckerbraun, MD, Myung S. Park, MD, Mitchell J. Cohen, MD, Stephen R. Wisniewski, PhD, James H. Morrissey, PhD, TACTIC Investigators

    Published 2022-06-01
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  15. 15
    MUlticenter STudy of tissue plasminogen activator (alteplase) use in COVID‐19 severe respiratory failure (MUST COVID): A retrospective cohort study

    MUlticenter STudy of tissue plasminogen activator (alteplase) use in COVID‐19 severe respiratory failure (MUST COVID): A retrospective cohort study by Christopher D. Barrett, Hunter B. Moore, Ernest E. Moore, Dudley Benjamin Christie III, Sarah Orfanos, Lorenzo Anez‐Bustillos, Rashi Jhunjhunwala, Sabiha Hussain, Shahzad Shaefi, Janice Wang, Negin Hajizadeh, Elias N. Baedorf‐Kassis, Ammar Al‐Shammaa, Krystal Capers, Valerie Banner‐Goodspeed, Franklin L. Wright, Todd Bull, Peter K. Moore, Hannah Nemec, John Thomas Buchanan, Cory Nonnemacher, Natalie Rajcooar, Ramona Ramdeo, Mena Yacoub, Ana Guevara, Aileen Espinal, Laith Hattar, Andrew Moraco, Robert McIntyre, Daniel S. Talmor, Angela Sauaia, Michael B. Yaffe

    Published 2022-02-01
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  16. 16
    Integration of the phosphorylation-dependent signaling in the DNA damage response network : implications for cancer

    Integration of the phosphorylation-dependent signaling in the DNA damage response network : implications for cancer by Manke, Isaac Andrew

    Published 2006
    Other Authors: “…Michael B. Yaffe.…”
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  17. 17
    A novel high-throughput in-cell Western assay for the quantitative measurement of signaling dynamics in DNA damage signaling networks : cell decision processes in response to DNA double strand breaks

    A novel high-throughput in-cell Western assay for the quantitative measurement of signaling dynamics in DNA damage signaling networks : cell decision processes in response to DNA d... by Tentner, Andrea R. (Andrea Ruth)

    Published 2006
    Other Authors: “…Michael B. Yaffe.…”
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  18. 18
    Modulation of mitotic progression and cell cycle checkpoints by phosphorylation-dependent protein-protein interactions

    Modulation of mitotic progression and cell cycle checkpoints by phosphorylation-dependent protein-protein interactions by Lowery, Drew M

    Published 2008
    Other Authors: “…Michael B. Yaffe.…”
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    Thesis
  19. 19
    Roles for motifs of cell cycle regulating kinases beyond substrate selection of individual kinases

    Roles for motifs of cell cycle regulating kinases beyond substrate selection of individual kinases by Alexander, Jes

    Published 2009
    Other Authors: “…Michael B. Yaffe.…”
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  20. 20
    Identification of new functions for BRCT domains

    Identification of new functions for BRCT domains by Mohammad, Duaa H

    Published 2009
    Other Authors: “…Michael B. Yaffe.…”
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