Targeting DNA hypermethylation: Computational modeling of DNA demethylation treatment of acute myeloid leukemia by Jens Przybilla, Lydia Hopp, Michael Lübbert, Markus Loeffler, Joerg Galle

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Absence of early platelet increment in healthy mice during decitabine treatment by Juliane Baumann, Markus Spindler, Yannick Throm, Michael Lübbert, Markus Bender

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Epigenetics in Pancreatic Ductal Adenocarcinoma: Impact on Biology and Utilization in Diagnostics and Treatment by Asmaa Elrakaybi, Dietrich A. Ruess, Michael Lübbert, Michael Quante, Heiko Becker

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The epigenetics of breast cancer – Opportunities for diagnostics, risk stratification and therapy by Rieke Schröder, Anna-Lena Illert, Thalia Erbes, Christian Flotho, Michael Lübbert, Jesús Duque-Afonso

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Impact of the Injection Site on Growth Characteristics, Phenotype and Sensitivity towards Cytarabine of Twenty Acute Leukaemia Patient-Derived Xenograft Models by Julia Schueler, Gabriele Greve, Dorothée Lenhard, Milena Pantic, Anna Edinger, Eva Oswald, Michael Lübbert

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Epigenetic priming of AML blasts for all-trans retinoic acid-induced differentiation by the HDAC class-I selective inhibitor entinostat. by Nadja Blagitko-Dorfs, Yi Jiang, Jesús Duque-Afonso, Jan Hiller, Arzu Yalcin, Gabriele Greve, Mahmoud Abdelkarim, Björn Hackanson, Michael Lübbert

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Long-term decitabine/retinoic acid maintenance treatment in an elderly sAML patient with high-risk genetics by Nora Rebeka Javorniczky, Olga Grishina, Inga Hund, Milena Pantic, Dietmar Pfeifer, Claudia Schmoor, Johanna Thomas, Justus Duyster, Heiko Becker, Michael Lübbert

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Functional Characterization of Transforming Growth Factor-β Signaling in Dasatinib Resistance and Pre-BCR⁺ Acute Lymphoblastic Leukemia by Gila Mostufi-Zadeh-Haghighi, Pia Veratti, Kyra Zodel, Gabriele Greve, Miguel Waterhouse, Robert Zeiser, Michael L. Cleary, Michael Lübbert, Jesús Duque-Afonso

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Bisulfite-free epigenomics and genomics of single cells through methylation-sensitive restriction by Christoph Niemöller, Julius Wehrle, Julian Riba, Rainer Claus, Nathalie Renz, Janika Rhein, Sabine Bleul, Juliane M. Stosch, Justus Duyster, Christoph Plass, Pavlo Lutsik, Daniel B. Lipka, Michael Lübbert, Heiko Becker

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Molecular Genetic Characterization of Individual Cancer Cells Isolated via Single-Cell Printing. by Julian Riba, Nathalie Renz, Christoph Niemöller, Sabine Bleul, Dietmar Pfeifer, Juliane M Stosch, Klaus H Metzeler, Björn Hackanson, Michael Lübbert, Justus Duyster, Peter Koltay, Roland Zengerle, Rainer Claus, Stefan Zimmermann, Heiko Becker

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The antileukemic activity of decitabine upon PML/RARA-negative AML blasts is supported by all-trans retinoic acid: in vitro and in vivo evidence for cooperation by Ruth Meier, Gabriele Greve, Dennis Zimmer, Helena Bresser, Bettina Berberich, Ralitsa Langova, Julia Stomper, Anne Rubarth, Lars Feuerbach, Daniel B. Lipka, Joschka Hey, Björn Grüning, Benedikt Brors, Justus Duyster, Christoph Plass, Heiko Becker, Michael Lübbert

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P480: DNMT AND HDAC INHIBITION INDUCES IMMUNOGENIC NEOANTIGENS FROM HUMAN ENDOGENOUS RETROVIRAL ELEMENT-DERIVED TRANSCRIPTS by Ashish Goyal, Jens Bauer, Joschka Hey, Dimitris Papageorgiou, Ekaterina Stepanova, Michael Daskalakis, Marissa Dubbelaar, Boris Klimovich, Melanie Maerklin, Malte Roerden, Oliver Muecke, Hans-Georg Rammensee, Fabricio Loayza-Puch, Jeroen Krijgsveld, Michael Lübbert, Juliane Walz, Christoph Plass

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Survival Improvement over Time of 960 s-AML Patients Included in 13 EORTC-GIMEMA-HOVON Trials by Safaa M. Ramadan, Stefan Suciu, Marian J. P. L. Stevens-Kroef, Roelof Willemze, Sergio Amadori, Theo de Witte, Bob Löwenberg, Petra Muus, Boris Labar, Liv Meert, Gaetan de Schaetzen, Giovanna Meloni, Giuseppe Leone, Marco Vignetti, Jean-Pierre Marie, Michael Lübbert, Frédéric Baron

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DNMT and HDAC inhibition induces immunogenic neoantigens from human endogenous retroviral element-derived transcripts by Ashish Goyal, Jens Bauer, Joschka Hey, Dimitris N. Papageorgiou, Ekaterina Stepanova, Michael Daskalakis, Jonas Scheid, Marissa Dubbelaar, Boris Klimovich, Dominic Schwarz, Melanie Märklin, Malte Roerden, Yu-Yu Lin, Tobias Ma, Oliver Mücke, Hans-Georg Rammensee, Michael Lübbert, Fabricio Loayza-Puch, Jeroen Krijgsveld, Juliane S. Walz, Christoph Plass

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S120: MNX1-ACTIVATING ENHANCER HIJACKING EVENTS IN ACUTE MYELOID LEUKEMIA WITH DELETIONS ON CHROMOSOME 7Q by Anna Riedel, Justyna A. Wierzbińska, Umut H. Toprak, Aurore Touzart, Etienne Sollier, Simge Kelekçi, Katherine Kelly, Dieter Weichenhan, Anastasija Pejkovska, Ashish Goyal, Charlotte Meinen, Matthias Schlesner, Frank Westermann, Benedikt Brors, Lars Bullinger, Philipp Greif, Michael Lübbert, Florian Heidel, Thomas Fischer, Claudia Gebhard, Brigitte Schlegelberger, Gudrun Göhring, Yvonne Behrens, Ekaterina Jahn, Hartmut Döhner, Konstanze Döhner, Ruud Delwel, Pavlo Lutsik, Daniel B. Lipka, Christoph Plass

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S135: NEXT-GENERATION SEQUENCING-BASED MEASURABLE RESIDUAL DISEASE MONITORING IN ACUTE MYELOID LEUKEMIA WITH FLT3 INTERNAL TANDEM DUPLICATION TREATED WITH INTENSIVE CHEMOTHERAPY PL... by Frank G Rücker, Lars Bullinger, Sibylle Cocciardi, Sabrina Skambraks, Tamara J Luck, Daniela Weber, Isabelle Schneider, Andrea Corbacioglu, Verena I Gaidzik, Ekaterina Jahn, Nikolaus Jahn, Silke Kapp-Schwoerer, Anika Schrade, Frauke Theis, Walter Fiedler, Helmut R Salih, Gerald Wulf, Hans Salwender, Thomas Schroeder, Katharina S Götze, Thomas Kindler, Michael Lübbert, Richard F Schlenk, Felicitas Thol, Michael Heuser, Arnold Ganser, Hartmut Döhner, Konstanze Döhner

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Oncogenic KrasG12D causes myeloproliferation via NLRP3 inflammasome activation by Shaima’a Hamarsheh, Lena Osswald, Benedikt S. Saller, Susanne Unger, Donatella De Feo, Janaki Manoja Vinnakota, Martina Konantz, Franziska M. Uhl, Heiko Becker, Michael Lübbert, Khalid Shoumariyeh, Christoph Schürch, Geoffroy Andrieux, Nils Venhoff, Annette Schmitt-Graeff, Sandra Duquesne, Dietmar Pfeifer, Matthew A. Cooper, Claudia Lengerke, Melanie Boerries, Justus Duyster, Charlotte M. Niemeyer, Miriam Erlacher, Bruce R. Blazar, Burkard Becher, Olaf Groß, Tilman Brummer, Robert Zeiser

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P719: RANDOMIZED PHASE 1-2 STUDY TO ASSESS SAFETY AND EFFICACY OF LOW-DOSE (LD) ORAL DECITABINE/CEDAZURIDINE (ASTX727) IN LOWER-RISK MYELODYSPLASTIC SYNDROMES (LR-MDS) PATIENTS: IN... by Guillermo Garcia-Manero, Kimo Bachishvili, Elizabeth A. Griffiths, Amer M. Zeidan, Elie Traer, Lalit Saini, Harshad Amin, Sanjay Mohan, Michael Lübbert, Lori Maness-Harris, James M Foran, Dominik Selleslag, Blanca Xicoy Cirici, Daniel Aaron Pollyea, David Sallman, Aref Al-Kali, Jesus Berdeja, Haifa Kathrin Al-Ali, Nancy Y Zhu, Patricia Font Lopez, Guillermo Sanz Santillana, Valeria Santini, Habte A. Yimer, Larry D Cripe, Victor Priego, Olatoyosi Odenike, Bert Heyrman, David Valcarcel, Pankit Vachhani, Yuri Sano, Beloo Mirakhur, Aram Oganesian, Harold Keer, Abdulraheem Yacoub

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RAS-pathway mutation patterns define epigenetic subclasses in juvenile myelomonocytic leukemia by Daniel B. Lipka, Tania Witte, Reka Toth, Jing Yang, Manuel Wiesenfarth, Peter Nöllke, Alexandra Fischer, David Brocks, Zuguang Gu, Jeongbin Park, Brigitte Strahm, Marcin Wlodarski, Ayami Yoshimi, Rainer Claus, Michael Lübbert, Hauke Busch, Melanie Boerries, Mark Hartmann, Maximilian Schönung, Umut Kilik, Jens Langstein, Justyna A. Wierzbinska, Caroline Pabst, Swati Garg, Albert Catalá, Barbara De Moerloose, Michael Dworzak, Henrik Hasle, Franco Locatelli, Riccardo Masetti, Markus Schmugge, Owen Smith, Jan Stary, Marek Ussowicz, Marry M. van den Heuvel-Eibrink, Yassen Assenov, Matthias Schlesner, Charlotte Niemeyer, Christian Flotho, Christoph Plass

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