Prediction of worsening heart failure events and all‐cause mortality using an individualized risk stratification strategy von Michael R. Zile, Jodi Koehler, Shantanu Sarkar, Javed Butler

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426 A Beat Away from Precision Medicine: Characterizing Human Cardiac Fibroblast Responsiveness to Hemodynamic Unloading in Heart Failure with Reduced Ejection Fraction von Rachel Biggs, Daniel N. Silverman, Yuhua Zhang, Catalin F. Baicu, Michael R. Zile, Amy D. Bradshaw

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β3 integrin in cardiac fibroblast is critical for extracellular matrix accumulation during pressure overload hypertrophy in mouse. von Sundaravadivel Balasubramanian, Lakeya Quinones, Harinath Kasiganesan, Yuhua Zhang, Dorea L Pleasant, Kamala P Sundararaj, Michael R Zile, Amy D Bradshaw, Dhandapani Kuppuswamy

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Cost-impact analysis of baroreflex activation therapy in chronic heart failure patients in the United States von John Bisognano, John E. Schneider, Shawn Davies, Robert L. Ohsfeldt, Elizabeth Galle, Ivana Stojanovic, Thomas F. Deering, JoAnn Lindenfeld, Michael R. Zile

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Pragmatic Weight Management Program for Patients With Obesity and Heart Failure With Preserved Ejection Fraction von Elia C. El Hajj, Milad C. El Hajj, Brandon Sykes, Melissa Lamicq, Michael R. Zile, Robert Malcolm, Patrick M. O’Neil, Sheldon E. Litwin

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Phenotypic characterization of primary cardiac fibroblasts from patients with HFpEF. von Yuhua Zhang, An O Van Laer, Catalin F Baicu, Lily S Neff, Stanley Hoffman, Marc R Katz, Sanford M Zeigler, Michael R Zile, Amy D Bradshaw

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STAT3 Activation in Pressure-Overloaded Feline Myocardium: Role for Integrins and the Tyrosine Kinase BMX von Christopher D. Willey, Arun P. Palanisamy, Rebecca K. Johnston, Santhosh K. Mani, Hirokazu Shiraishi, William J. Tuxworth, Michael R. Zile, Sundaravadivel Balasubramanian, Dhandapani Kuppuswamy

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Elevated Wall Tension Leads to Reduced miR‐133a in the Thoracic Aorta by Exosome Release von Adam W. Akerman, Walker M. Blanding, Robert E. Stroud, Elizabeth K. Nadeau, Rupak Mukherjee, Jean Marie Ruddy, Michael R. Zile, John S. Ikonomidis, Jeffrey A. Jones

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Acute Hemodynamic Effects of Cardiac Resynchronization Therapy Versus Alternative Pacing Strategies in Patients With Left Ventricular Assist Devices von Brett Tomashitis, Catalin F. Baicu, Ross A. Butschek, Gregory R. Jackson, Jeffrey Winterfield, Ryan J. Tedford, Michael R. Zile, Michael R. Gold, Brian A. Houston

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Left ventricle function and post-transcriptional events with exercise training in pigs. von Stephanie L Samani, Shayne C Barlow, Lisa A Freeburg, Traci L Jones, Marlee Poole, Mark A Sarzynski, Michael R Zile, Tarek Shazly, Francis G Spinale

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Lactosylceramide contributes to mitochondrial dysfunction in diabetes von Sergei A. Novgorodov, Christopher L. Riley, Jin Yu, Jarryd A. Keffler, Christopher J. Clarke, An O. Van Laer, Catalin F. Baicu, Michael R. Zile, Tatyana I. Gudz

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Prognostic Value of Minimal Left Atrial Volume in Heart Failure With Preserved Ejection Fraction von Sung‐Hee Shin, Brian Claggett, Riccardo M. Inciardi, Angela B. S. Santos, Sanjiv J. Shah, Michael R. Zile, Marc A. Pfeffer, Amil M. Shah, Scott D. Solomon

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Acute pulmonary pressure change after transition to sacubitril/valsartan in patients with heart failure reduced ejection fraction von Jeffrey S. Tran, Ofer Havakuk, Jennifer M. McLeod, Jennifer Hwang, Hoi Yan Kwong, David Shavelle, Michael R. Zile, Uri Elkayam, Michael W. Fong, Luanda P. Grazette

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Personalized Intervention Strategy Based on a Risk Score Generated From Subcutaneous Insertable Cardiac Monitor: Results From Phase 1 of ALLEVIATE‐HF von Rami Kahwash, Michael R. Zile, Prasad Chalasani, Barry Bertolet, Laura Gravelin, Muhammad Shahzeb Khan, Jennifer Wehking, Brian Van Dorn, Shantanu Sarkar, Verla Laager, Bart Gerritse, Aimee Laechelt, Javed Butler

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INTERVENE‐HF: feasibility study of individualized, risk stratification‐based, medication intervention in patients with heart failure with reduced ejection fraction von Michael R. Zile, Maria Rosa R. Costanzo, Ekaterina M. Ippolito, Yan Zhang, Russell Stapleton, Ashish Sadhu, Javier Jimenez, Joe Hobbs, Vinod Sharma, Eduardo N. Warman, Lindsay Streeter, Javed Butler

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Relationship between duration of heart failure, patient characteristics, outcomes, and effect of therapy in PARADIGM‐HF von Su E. Yeoh, Pooja Dewan, Akshay S. Desai, Scott D. Solomon, Jean L. Rouleau, Marty Lefkowitz, Adel Rizkala, Karl Swedberg, Michael R. Zile, Pardeep S. Jhund, Milton Packer, John J.V. McMurray

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Activation of Inflammatory and Pro-Thrombotic Pathways in Acute Stress Cardiomyopathy von Timothy P. Fitzgibbons, Yvonne J. K. Edwards, Peter Shaw, Aline Iskandar, Mohamed Ahmed, Josiah Bote, Tejen Shah, Sumita Sinha, Robert E. Gerszten, John F. Keaney, Michael R. Zile, Gerard P. Aurigemma

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Cardiosphere-Derived Cells Reverse Heart Failure With Preserved Ejection Fraction in Rats by Decreasing Fibrosis and Inflammation von Romain Gallet, MD, Geoffrey de Couto, PhD, Eli Simsolo, BS, Jackelyn Valle, BS, Baiming Sun, MD, Weixin Liu, MS, Eleni Tseliou, MD, Michael R. Zile, MD, Eduardo Marbán, MD, PhD

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Impact of diabetes on serum biomarkers in heart failure with preserved ejection fraction: insights from the TOPCAT trial von Corrado De Marco, Brian L. Claggett, Simon deDenus, Michael R. Zile, Thao Huynh, Akshay S. Desai, Martin G. Sirois, Scott D. Solomon, Bertram Pitt, Jean L. Rouleau, Marc A. Pfeffer, Eileen O'Meara

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Heart failure with preserved ejection fraction, red cell distribution width, and sacubitril/valsartan von Jawad H. Butt, Kirsty McDowell, Toru Kondo, Akshay S. Desai, Martin P. Lefkowitz, Milton Packer, Mark C. Petrie, Marc A. Pfeffer, Jean L. Rouleau, Muthiah Vaduganathan, Michael R. Zile, Pardeep S. Jhund, Lars Køber, Scott Solomon, John J.V. McMurray

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