426 A Beat Away from Precision Medicine: Characterizing Human Cardiac Fibroblast Responsiveness to Hemodynamic Unloading in Heart Failure with Reduced Ejection Fraction by Rachel Biggs, Daniel N. Silverman, Yuhua Zhang, Catalin F. Baicu, Michael R. Zile, Amy D. Bradshaw

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β3 integrin in cardiac fibroblast is critical for extracellular matrix accumulation during pressure overload hypertrophy in mouse. by Sundaravadivel Balasubramanian, Lakeya Quinones, Harinath Kasiganesan, Yuhua Zhang, Dorea L Pleasant, Kamala P Sundararaj, Michael R Zile, Amy D Bradshaw, Dhandapani Kuppuswamy

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Pragmatic Weight Management Program for Patients With Obesity and Heart Failure With Preserved Ejection Fraction by Elia C. El Hajj, Milad C. El Hajj, Brandon Sykes, Melissa Lamicq, Michael R. Zile, Robert Malcolm, Patrick M. O’Neil, Sheldon E. Litwin

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Left ventricle function and post-transcriptional events with exercise training in pigs. by Stephanie L Samani, Shayne C Barlow, Lisa A Freeburg, Traci L Jones, Marlee Poole, Mark A Sarzynski, Michael R Zile, Tarek Shazly, Francis G Spinale

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Personalized Intervention Strategy Based on a Risk Score Generated From Subcutaneous Insertable Cardiac Monitor: Results From Phase 1 of ALLEVIATE‐HF by Rami Kahwash, Michael R. Zile, Prasad Chalasani, Barry Bertolet, Laura Gravelin, Muhammad Shahzeb Khan, Jennifer Wehking, Brian Van Dorn, Shantanu Sarkar, Verla Laager, Bart Gerritse, Aimee Laechelt, Javed Butler

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Heart failure with preserved ejection fraction, red cell distribution width, and sacubitril/valsartan by Jawad H. Butt, Kirsty McDowell, Toru Kondo, Akshay S. Desai, Martin P. Lefkowitz, Milton Packer, Mark C. Petrie, Marc A. Pfeffer, Jean L. Rouleau, Muthiah Vaduganathan, Michael R. Zile, Pardeep S. Jhund, Lars Køber, Scott Solomon, John J.V. McMurray

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In vivo fluid dynamics of the Ventura interatrial shunt device in patients with heart failure by Michael Pfeiffer, John Boehmer, John Gorcsan, Shunsuke Eguchi, Yoshiyuki Orihara, Michal Laufer Perl, Neal Eigler, William T. Abraham, Julio Nuñez Villota, Elizabeth Lee, Antoni Bayés‐Genís, Gil Moravsky, Saibal Kar, Michael R. Zile, Richard Holcomb, Stefan D. Anker, Gregg W. Stone, Josep Rodés‐Cabau, JoAnn Lindenfeld, Jeroen J. Bax

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Clinical Characteristics and Outcomes of Patients With Heart Failure With Preserved Ejection Fraction and With Reduced Ejection Fraction According to the Prognostic Nutritional Ind... by Simone Solano, Mingming Yang, Paolo Tolomeo, Toru Kondo, Li Shen, Pardeep S. Jhund, Inder S. Anand, Akshay S. Desai, Carolyn S. P. Lam, Aldo P. Maggioni, Felipe A. Martinez, Jean L. Rouleau, Muthiah Vaduganathan, Dirk J. van Veldhuisen, Faiez Zannad, Michael R. Zile, Milton Packer, Scott D. Solomon, John J. V. McMurray

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Impact of Chronic Obstructive Pulmonary Disease in Patients With Heart Failure With Preserved Ejection Fraction: Insights From PARAGON‐HF by Leanne Mooney, Nathaniel M. Hawkins, Pardeep S. Jhund, Margaret M. Redfield, Muthiah Vaduganathan, Akshay S. Desai, Jean L. Rouleau, Masatoshi Minamisawa, Amil M. Shah, Martin P. Lefkowitz, Michael R. Zile, Dirk J. Van Veldhuisen, Marc A. Pfeffer, Inder S. Anand, Aldo P. Maggioni, Michele Senni, Brian L. Claggett, Scott D. Solomon, John J. V. McMurray

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Aptamer Proteomics for Biomarker Discovery in Heart Failure With Preserved Ejection Fraction: The PARAGON‐HF Proteomic Substudy by Natasha L. Patel‐Murray, Luqing Zhang, Brian L. Claggett, Dongchu Xu, Pablo Serrano‐Fernandez, Margaret Healey, Simon Wandel, Chien‐Wei Chen, Jaison Jacob, Huilei Xu, Gordon M. Turner, William Chutkow, Denise P. Yates, Christopher J. O'Donnell, Margaret F. Prescott, Martin Lefkowitz, Claudio R. Gimpelewicz, Michael T. Beste, Faye Zhao, Liangke Gou, Akshay S. Desai, Pardeep S. Jhund, Milton Packer, Marc A. Pfeffer, Margaret M. Redfield, Jean L. Rouleau, Faiez Zannad, Michael R. Zile, John J. V. McMurray, Michael M. Mendelson, Scott D. Solomon, Jonathan W. Cunningham

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