Octopamine signaling in the metazoan pathogen Schistosoma mansoni: localization, small-molecule screening and opportunities for drug development by Nelly El-Sakkary, Steven Chen, Michelle R. Arkin, Conor R. Caffrey, Paula Ribeiro

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A multi-dimensional, time-lapse, high content screening platform applied to schistosomiasis drug discovery by Steven Chen, Brian M. Suzuki, Jakob Dohrmann, Rahul Singh, Michelle R. Arkin, Conor R. Caffrey

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A screen against Leishmania intracellular amastigotes: comparison to a promastigote screen and identification of a host cell-specific hit. by Geraldine De Muylder, Kenny K H Ang, Steven Chen, Michelle R Arkin, Juan C Engel, James H McKerrow

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Identification of Plasmodium dipeptidyl aminopeptidase allosteric inhibitors by high throughput screening. by Mateo I Sanchez, Laura E de Vries, Christine Lehmann, Jeong T Lee, Kenny K Ang, Christopher Wilson, Steven Chen, Michelle R Arkin, Matthew Bogyo, Edgar Deu

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Functional Assessment of 2,177 U.S. and International Drugs Identifies the Quinoline Nitroxoline as a Potent Amoebicidal Agent against the Pathogen <italic toggle="yes">Balamuthia... by Matthew T. Laurie, Corin V. White, Hanna Retallack, Wesley Wu, Matthew S. Moser, Judy A. Sakanari, Kenny Ang, Christopher Wilson, Michelle R. Arkin, Joseph L. DeRisi

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Voreloxin is an anticancer quinolone derivative that intercalates DNA and poisons topoisomerase II. by Rachael E Hawtin, David E Stockett, Jo Ann W Byl, Robert S McDowell, Tan Nguyen, Michelle R Arkin, Andrew Conroy, Wenjin Yang, Neil Osheroff, Judith A Fox

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Imaging-based chemical screening reveals activity-dependent neural differentiation of pluripotent stem cells by Yaping Sun, Zhiqiang Dong, Taihao Jin, Kean-Hooi Ang, Miller Huang, Kelly M Haston, Jisong Peng, Tao P Zhong, Steven Finkbeiner, William A Weiss, Michelle R Arkin, Lily Y Jan, Su Guo

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Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch by Ciara M Gallagher, Carolina Garri, Erica L Cain, Kenny Kean-Hooi Ang, Christopher G Wilson, Steven Chen, Brian R Hearn, Priyadarshini Jaishankar, Andres Aranda-Diaz, Michelle R Arkin, Adam R Renslo, Peter Walter

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Diverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51. by Shamila S Gunatilleke, Claudia M Calvet, Jonathan B Johnston, Chiung-Kuang Chen, Grigori Erenburg, Jiri Gut, Juan C Engel, Kenny K H Ang, Joseph Mulvaney, Steven Chen, Michelle R Arkin, James H McKerrow, Larissa M Podust

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Mining a cathepsin inhibitor library for new antiparasitic drug leads. by Kenny K H Ang, Joseline Ratnam, Jiri Gut, Jennifer Legac, Elizabeth Hansell, Zachary B Mackey, Katarzyna M Skrzypczynska, Anjan Debnath, Juan C Engel, Philip J Rosenthal, James H McKerrow, Michelle R Arkin, Adam R Renslo

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A gene-expression screen identifies a non-toxic sumoylation inhibitor that mimics SUMO-less human LRH-1 in liver by Miyuki Suzawa, Diego A Miranda, Karmela A Ramos, Kenny K-H Ang, Emily J Faivre, Christopher G Wilson, Laura Caboni, Michelle R Arkin, Yeong-Sang Kim, Robert J Fletterick, Aaron Diaz, John S Schneekloth Jr, Holly A Ingraham

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An Integrated Approach to Identify New Anti-Filarial Leads to Treat River Blindness, a Neglected Tropical Disease by Rahul Tyagi, Christina A. Bulman, Fidelis Cho-Ngwa, Chelsea Fischer, Chris Marcellino, Michelle R. Arkin, James H. McKerrow, Case W. McNamara, Matthew Mahoney, Nancy Tricoche, Shabnam Jawahar, James W. Janetka, Sara Lustigman, Judy Sakanari, Makedonka Mitreva

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Pharmacological brake-release of mRNA translation enhances cognitive memory by Carmela Sidrauski, Diego Acosta-Alvear, Arkady Khoutorsky, Punitha Vedantham, Brian R Hearn, Han Li, Karine Gamache, Ciara M Gallagher, Kenny K-H Ang, Chris Wilson, Voytek Okreglak, Avi Ashkenazi, Byron Hann, Karim Nader, Michelle R Arkin, Adam R Renslo, Nahum Sonenberg, Peter Walter

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A zebrafish screen reveals Renin-angiotensin system inhibitors as neuroprotective via mitochondrial restoration in dopamine neurons by Gha-Hyun J Kim, Han Mo, Harrison Liu, Zhihao Wu, Steven Chen, Jiashun Zheng, Xiang Zhao, Daryl Nucum, James Shortland, Longping Peng, Mannuel Elepano, Benjamin Tang, Steven Olson, Nick Paras, Hao Li, Adam R Renslo, Michelle R Arkin, Bo Huang, Bingwei Lu, Marina Sirota, Su Guo

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Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6. by Christopher E Heise, Jeremy Murray, Katherine E Augustyn, Brandon Bravo, Preeti Chugha, Frederick Cohen, Anthony M Giannetti, Paul Gibbons, Rami N Hannoush, Brian R Hearn, Priyadarshini Jaishankar, Cuong Q Ly, Kinjalkumar Shah, Karen Stanger, Micah Steffek, Yinyan Tang, Xianrui Zhao, Joseph W Lewcock, Adam R Renslo, John Flygare, Michelle R Arkin

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Chemical–biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target by Jonathan W. Choy, Clifford Bryant, Claudia M. Calvet, Patricia S. Doyle, Shamila S. Gunatilleke, Siegfried S. F. Leung, Kenny K. H. Ang, Steven Chen, Jiri Gut, Juan A. Oses-Prieto, Jonathan B. Johnston, Michelle R. Arkin, Alma L. Burlingame, Jack Taunton, Matthew P. Jacobson, James M. McKerrow, Larissa M. Podust, Adam R. Renslo

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Guidelines for DNA recombination and repair studies: Mechanistic assays of DNA repair processes by Hannah L Klein, Kenny K.H. Ang, Michelle R. Arkin, Emily C. Beckwitt, Yi-Hsuan Chang, Jun Fan, Youngho Kwon, Michael J. Morten, Sucheta Mukherjee, Oliver J. Pambos, Hafez el Sayyed, Elizabeth S. Thrall, João P. Vieira-da-Rocha, Quan Wang, Shuang Wang, Hsin-Yi Yeh, Julie S. Biteen, Peter Chi, Wolf-Dietrich Heyer, Achillefs N. Kapanidis, Joseph J. Loparo, Terence R. Strick, Patrick Sung, Bennett Van Houten, Hengyao Niu, Eli Rothenberg

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