Prognostic impact of pretreatment immunoglobulin clonal composition in pediatric B-lymphoblastic leukemia by Carol Fries, Lik Wee Lee, Meenakshi Devidas, Yunfeng Dai, Karen R. Rabin, Sumit Gupta, Mignon L. Loh, Ilan R Kirsch, Brent Wood, Rachel E. Rau

Get full text

NSD2 E1099K drives relapse in pediatric acute lymphoblastic leukemia by disrupting 3D chromatin organization by Sonali Narang, Nikki A. Evensen, Jason Saliba, Joanna Pierro, Mignon L. Loh, Patrick A. Brown, Pandurang Kolekar, Heather Mulder, Ying Shao, John Easton, Xiaotu Ma, Aristotelis Tsirigos, William L. Carroll

Get full text

SARS‐CoV‐2 infections in patients enrolled on the Children's Oncology Group standard‐risk B‐cell acute lymphoblastic leukemia trial, AALL1731 by Caitlin W. Elgarten, John A. Kairalla, Joel C. Thompson, Tamara P. Miller, Cindy Wang, Susan Conway, Mignon L. Loh, Elizabeth A. Raetz, Sumit Gupta, Rachel E. Rau, Anne Angiolillo, Karen R. Rabin, Sarah Alexander

Get full text

Oncogenic role and therapeutic targeting of ABL-class and JAK-STAT activating kinase alterations in Ph-like ALL by Kathryn G. Roberts, Yung-Li Yang, Debbie Payne-Turner, Wenwei Lin, Jacob K. Files, Kirsten Dickerson, Zhaohui Gu, Jack Taunton, Laura J. Janke, Taosheng Chen, Mignon L. Loh, Stephen P. Hunger, Charles G. Mullighan

Get full text

S107: IDENTIFICATION AND CHARACTERIZATION OF GERMLINE NBN VARIANTS RELATED TO B-ALL PREDISPOSITION by Carolin Escherich, Wenan Chen, Wenjian Yang, David T. Teachey, Elizabeth A. Raetz, Meenakshi Devidas, Gang Wu, Kim E. Nichols, Hiroto Inaba, Ching-Hon Pui, Sima Jeha, Stephen P. Hunger, Mignon L. Loh, Jun J. Yang

Get full text

High immunoproteasome and low constitutive proteasome subunit levels correlate with sensitivity to bortezomib-containing chemotherapy: update from the Children’s Oncology Group AAL... by Margot S. F. Roeten, Johan van Meerloo, Suzanne N. van Dijk, Zinia Kwidama, Gaye Jenkins, David T. Teachey, Meenakshi Devidas, Mignon L. Loh, Gertjan J. L. Kaspers, Sonja Zweegman, Gerrit Jansen, Terzah M. Horton, Jacqueline Cloos

Get full text

Recombinant Erwinia asparaginase (JZP458) in ALL/LBL: complete follow-up of the Children’s Oncology Group AALL1931 study by Luke Maese, Mignon L. Loh, Mi Rim Choi, Shirali Agarwal, Etsuko Aoki, Yali Liang, Tong Lin, Suzette Girgis, Cuiping Chen, Shane Roller, Vijayalakshmi Chandrasekaran, Robert Iannone, Lewis B. Silverman, Elizabeth A. Raetz, Rachel E. Rau

Get full text

The <i>EBF1-PDGFRB</i> T681I mutation is highly resistant to imatinib and dasatinib <i>in vitro</i> and detectable in clinical samples prior to treatment by Thai Hoa Tran, Jonathan V. Nguyen, Adrian Stecula, Jon Akutagawa, Anthony V. Moorman, Benjamin S. Braun, Andrej Sali, Charles G. Mullighan, Neil P. Shah, Yunfeng Dai, Meenakshi Devidas, Kathryn G. Roberts, Catherine C. Smith, Mignon L. Loh

Get full text

Impact of corticosteroid pretreatment in pediatric patients with newly diagnosed B-lymphoblastic leukemia: a report from the Children’s Oncology Group by Elizabeth A. Raetz, Mignon L. Loh, Meenakshi Devidas, Kelly Maloney, Leonard A. Mattano, Eric Larsen, Andrew Carroll, Nyla A. Heerema, Julie M. Gastier-Foster, Brent Wood, Michael J. Borowitz, Naomi Winick, Stephen P. Hunger, William L. Carroll

Get full text

Venetoclax and dinaciclib elicit synergistic preclinical efficacy against hypodiploid acute lymphoblastic leukemia by Holly Pariury, Joshua Fandel, Stefanie Bachl, Kenny K. Ang, Sarine Markossian, Chris G. Wilson, Benjamin S. Braun, Bogdan Popescu, Margo Wohlfeil, Kyle Beckman, Simayijiang Xirenayi, Ritu P. Roy, Adam B. Olshen, Catherine Smith, Michelle R. Arkin, Mignon L. Loh, Ernesto Diaz-Flores

Get full text

Outstanding outcomes in infants with <i>KMT2A</i>-germline acute lymphoblastic leukemia treated with chemotherapy alone: results of the Children’s Oncology Group AALL0631 trial by Erin M. Guest, John A. Kairalla, Joanne M. Hilden, ZoAnn E. Dreyer, Andrew J. Carroll, Nyla A. Heerema, Cindy Y. Wang, Meenakshi Devidas, Lia Gore, Wanda L. Salzer, Naomi J. Winick, William L. Carroll, Elizabeth A. Raetz, Michael Borowitz, Mignon L. Loh, Stephen P. Hunger, Patrick A. Brown

Get full text

Replacing cyclophosphamide/cytarabine/mercaptopurine with cyclophosphamide/etoposide during consolidation/delayed intensification does not improve outcome for pediatric B-cell acut... by Michael J. Burke, Wanda L. Salzer, Meenakshi Devidas, Yunfeng Dai, Lia Gore, Joanne M. Hilden, Eric Larsen, Karen R. Rabin, Patrick A. Zweidler-McKay, Michael J. Borowitz, Brent Wood, Nyla A. Heerema, Andrew J. Carroll, Naomi Winick, William L. Carroll, Elizabeth A. Raetz, Mignon L. Loh, Stephen P. Hunger

Get full text

Azacitidine as epigenetic priming for chemotherapy is safe and well-tolerated in infants with newly diagnosed KMT2A-rearranged acute lymphoblastic leukemia: Children’s Oncology Gro... by Erin M. Guest, John A. Kairalla, Meenakshi Devidas, Emily Hibbitts, Andrew J. Carroll, Nyla A. Heerema, Holly R. Kubaney, Margaret A. August, Sidharth Ramesh, Byunggil Yoo, Midhat S. Farooqi, Melinda G. Pauly, Daniel S. Wechsler, Rodney R. Miles, Joel M. Reid, Cynthia D. Kihei, Lia Gore, Elizabeth A. Raetz, Stephen P. Hunger, Mignon L. Loh, Patrick A. Brown

Get full text

Prognostic impact of kinase-activating fusions and IKZF1 deletions in pediatric high-risk B-lineage acute lymphoblastic leukemia by Thai Hoa Tran, Marian H. Harris, Jonathan V. Nguyen, Traci M. Blonquist, Kristen E. Stevenson, Eileen Stonerock, Barbara L. Asselin, Uma H. Athale, Luis A. Clavell, Peter D. Cole, Kara M. Kelly, Caroline Laverdiere, Jean-Marie Leclerc, Bruno Michon, Marshall A. Schorin, Jennifer J.G. Welch, Shalini C. Reshmi, Donna S. Neuberg, Stephen E. Sallan, Mignon L. Loh, Lewis B. Silverman

Get full text

Criteria for evaluating response and outcome in clinical trials for children with juvenile myelomonocytic leukemia by Charlotte M. Niemeyer, Mignon L. Loh, Annamaria Cseh, Todd Cooper, Christopher C. Dvorak, Rebecca Chan, Blanca Xicoy, Ulrich Germing, Seiji Kojima, Atsushi Manabe, Michael Dworzak, Barbara De Moerloose, Jan Starý, Owen P. Smith, Riccardo Masetti, Albert Catala, Eva Bergstraesser, Marek Ussowicz, Oskana Fabri, André Baruchel, Hélène Cavé, Michel Zwaan, Franco Locatelli, Henrik Hasle, Marry M. van den Heuvel-Eibrink, Christian Flotho, Ayami Yoshimi

Get full text

Molecular and pharmacological heterogeneity of ETV6::RUNX1 acute lymphoblastic leukemia by Zhenhua Li, Huanbin Zhao, Wenjian Yang, Maud Maillard, Satoshi Yoshimura, Yu-Chih Hsiao, Xin Huang, Yoshihiro Gocho, Lauren Rowland, Anthony Brown, Landon Choi, Kristine R. Crews, Charles G. Mullighan, Samuel W. Brady, Cheng Cheng, Ti-Cheng Chang, Gang Wu, Mignon L. Loh, Allen Eng Juh Yeoh, Federico Antillon-Klussmann, Sima Jeha, Hiroto Inaba, Jiyang Yu, Ching-Hon Pui, Seth E. Karol, William E. Evans, Jun J. Yang

Get full text

LNK/<i>SH2B3</i> as a novel driver in juvenile myelomonocytic leukemia by Astrid Wintering, Anna Hecht, Julia Meyer, Eric B. Wong, Juwita Hübner, Sydney Abelson, Kira Feldman, Vanessa E. Kennedy, Cheryl A.C. Peretz, Deborah L. French, Jean Ann Maguire, Chintan Jobaliya, Marta Rojas Vasquez, Sunil Desai, Robin Dulman, Eneida Nemecek, Hilary Haines, Mahmoud Hammad, Alaa El Haddad, Scott C. Kogan, Zied Abdullaev, Farid F. Chehab, Sarah K. Tasian, Catherine C. Smith, Mignon L. Loh, Elliot Stieglitz

Get full text

Characterization of leukemias with ETV6-ABL1 fusion by Marketa Zaliova, Anthony V. Moorman, Giovanni Cazzaniga, Martin Stanulla, Richard C. Harvey, Kathryn G. Roberts, Sue L. Heatley, Mignon L. Loh, Marina Konopleva, I-Ming Chen, Olga Zimmermannova, Claire Schwab, Owen Smith, Marie-Joelle Mozziconacci, Christian Chabannon, Myungshin Kim, J. H. Frederik Falkenburg, Alice Norton, Karen Marshall, Oskar A. Haas, Julia Starkova, Jan Stuchly, Stephen P. Hunger, Deborah White, Charles G. Mullighan, Cheryl L. Willman, Jan Stary, Jan Trka, Jan Zuna

Get full text

Molecular and phenotypic diversity of <I>CBL</I>-mutated juvenile myelomonocytic leukemia by Anna Hecht, Julia A. Meyer, Astrid Behnert, Eric Wong, Farid Chehab, Adam Olshen, Aaron Hechmer, Catherine Aftandilian, Rukhmi Bhat, Sung Won Choi, Satheesh Chonat, Jason E. Farrar, Mark Fluchel, Haydar Frangoul, Jennifer H. Han, Edward A. Kolb, Dennis J. Kuo, Margaret L. MacMillan, Luke Maese, Kelly W. Maloney, Aru Narendran, Benjamin Oshrine, Kirk R. Schultz, Maria L. Sulis, David Van Mater, Sarah K. Tasian, Wolf-Karsten Hofmann, Mignon L. Loh, Elliot Stieglitz

Get full text

Molecular characterization and clinical outcome of B-cell precursor acute lymphoblastic leukemia with IG-MYC rearrangement by Simon Bomken, Amir Enshaei, Edward C. Schwalbe, Aneta Mikulasova, Yunfeng Dai, Masood Zaka, Kent T.M. Fung, Matthew Bashton, Huezin Lim, Lisa Jones, Nefeli Karataraki, Emily Winterman, Cody Ashby, Andishe Attarbaschi, Yves Bertrand, Jutta Bradtke, Barbara Buldini, G.A. Amos Burke, Giovanni Cazzaniga, Gudrun Gohring, Hesta A. de Groot-Kruseman, Claudia Haferlach, Luca Lo Nigro, Mayur Parihar, Adriana Plesa, Emma Seaford, Edwin Sonneveld, Sabine Strehl, Vincent H.J. van der Velden, Vikki Rand, Stephen P. Hunger, Christine J. Harrison, Chris M. Bacon, Frederik W. van Delft, Mignon L. Loh, John Moppett, Josef Vormoor, Brian A. Walker, Anthony V. Moorman, Lisa J. Russell

Get full text