Editorial: Mechanisms of action of small molecules on CFTR mutants and the impact on cystic fibrosis pathogenesis by Camille Ehre, Camille Ehre, Camille Ehre, Miquéias Lopes-Pacheco, Miquéias Lopes-Pacheco, Onofrio Laselva

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Functional enhancement strategies to potentiate the therapeutic properties of mesenchymal stromal cells for respiratory diseases by Miquéias Lopes-Pacheco, Patricia R. M. Rocco

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Cell-Based Therapy for Silicosis by Miquéias Lopes-Pacheco, Elga Bandeira, Marcelo M. Morales

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Organic Synthesis and Current Understanding of the Mechanisms of CFTR Modulator Drugs Ivacaftor, Tezacaftor, and Elexacaftor by Filipa C. Ferreira, Camilla D. Buarque, Miquéias Lopes-Pacheco

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Elexacaftor-Tezacaftor-Ivacaftor: A Life-Changing Triple Combination of CFTR Modulator Drugs for Cystic Fibrosis by Mafalda Bacalhau, Mariana Camargo, Grace A. V. Magalhães-Ghiotto, Sybelle Drumond, Carlos Henrique M. Castelletti, Miquéias Lopes-Pacheco

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The MSC-EV-microRNAome: A Perspective on Therapeutic Mechanisms of Action in Sepsis and ARDS by Claudia C. dos Santos, Miquéias Lopes-Pacheco, Karen English, Sara Rolandsson Enes, Anna Krasnodembskaya, Patricia R. M. Rocco

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Rescue of Mutant CFTR Channel Activity by Investigational Co-Potentiator Therapy by Mafalda Bacalhau, Filipa C. Ferreira, Marcelo Folhadella M. F. Azevedo, Talita P. Rosa, Camilla D. Buarque, Miquéias Lopes-Pacheco

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Advancements in understanding the mechanisms of lung–kidney crosstalk by Renata de Souza Mendes, Pedro Leme Silva, Chiara Robba, Denise Battaglini, Miquéias Lopes-Pacheco, Celso Caruso-Neves, Patricia R. M. Rocco

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Repeated Administration of Bone Marrow-Derived Cells Prevents Disease Progression in Experimental Silicosis by Miquéias Lopes-Pacheco, Debora G. Xisto, Felipe M. Ornellas, Mariana A. Antunes, Soraia C. Abreu, Patricia R.M. Rocco, Christina M. Takiya, Marcelo M. Morales

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Rescue of Mutant CFTR Trafficking Defect by the Investigational Compound MCG1516A by Miquéias Lopes-Pacheco, Mafalda Bacalhau, Sofia S. Ramalho, Iris A. L. Silva, Filipa C. Ferreira, Graeme W. Carlile, David Y. Thomas, Carlos M. Farinha, John W. Hanrahan, Margarida D. Amaral

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Laboratory Biomarkers for Diagnosis and Prognosis in COVID-19 by Denise Battaglini, Denise Battaglini, Denise Battaglini, Miquéias Lopes-Pacheco, Hugo C. Castro-Faria-Neto, Paolo Pelosi, Paolo Pelosi, Patricia R. M. Rocco, Patricia R. M. Rocco, Patricia R. M. Rocco

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Potential of extracellular vesicles in the pathogenesis, diagnosis and therapy for parasitic diseases by Ana Acacia Sá Pinheiro, Ana Claudia Torrecilhas, Bruno Solano de Freitas Souza, Fernanda Ferreira Cruz, Herbert Leonel de Matos Guedes, Tadeu Diniz Ramos, Miqueias Lopes‐Pacheco, Celso Caruso‐Neves, Patricia R. M. Rocco

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Global functional genomics reveals GRK5 as a cystic fibrosis therapeutic target synergistic with current modulators by Hugo M. Botelho, Miquéias Lopes-Pacheco, Madalena C. Pinto, Violeta Railean, Ines Pankonien, Mariana F. Caleiro, Luka A. Clarke, Vasco Cachatra, Beate Neumann, Christian Tischer, Cristina Moiteiro, Jiraporn Ousingsawat, Karl Kunzelmann, Rainer Pepperkok, Margarida D. Amaral

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Therapeutic effects of bone marrow-derived mononuclear cells from healthy or silicotic donors on recipient silicosis mice by Helena D’Anunciação de Oliveira, Elga Bernardo Bandeira de Melo, Johnatas Dutra Silva, Jamil Zola Kitoko, Bianca Gutfilen, Thiago Barboza, Sergio Augusto Lopes de Souza, Christina Maeda Takiya, Patricia Rieken Macedo Rocco, Miquéias Lopes-Pacheco, Marcelo Marcos Morales

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Mesenchymal Stromal Cells Are More Effective Than Their Extracellular Vesicles at Reducing Lung Injury Regardless of Acute Respiratory Distress Syndrome Etiology by Johnatas D. Silva, Ligia L. de Castro, Cassia L. Braga, Gisele P. Oliveira, Stefano A. Trivelin, Carlos M. Barbosa-Junior, Marcelo M. Morales, Claudia C. dos Santos, Daniel J. Weiss, Miquéias Lopes-Pacheco, Fernanda F. Cruz, Patricia R. M. Rocco

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CFTR interactome mapping using the mammalian membrane two‐hybrid high‐throughput screening system by Sang Hyun Lim, Jamie Snider, Liron Birimberg‐Schwartz, Wan Ip, Joana C Serralha, Hugo M Botelho, Miquéias Lopes‐Pacheco, Madalena C Pinto, Mohamed Taha Moutaoufik, Mara Zilocchi, Onofrio Laselva, Mohsen Esmaeili, Max Kotlyar, Anna Lyakisheva, Priscilla Tang, Lucía López Vázquez, Indira Akula, Farzaneh Aboualizadeh, Victoria Wong, Ingrid Grozavu, Teuta Opacak‐Bernardi, Zhong Yao, Meg Mendoza, Mohan Babu, Igor Jurisica, Tanja Gonska, Christine E Bear, Margarida D Amaral, Igor Stagljar

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