Suicide Gene Therapy to Increase the Safety of Chimeric Antigen Receptor-Redirected T Lymphocytes by Monica Casucci, Attilio Bondanza

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1242 Mouse model of CAR-related ICANS development after treatment with human CD19 CAR-T cells by Alice Bergamini, Barbara Camisa, Chiara Bonini, Monica Casucci, Laura Falcone, Elena Tiziano, Rita El Khoury, Rossana Norata, Francesca Sanvito, Tamara Canu, Patrizia D’Adamo

CD4 CAR-T cells targeting CD19 play a key role in exacerbating cytokine release syndrome, while maintaining long-term responses by Alice Bergamini, Barbara Camisa, Attilio Bondanza, Fabio Ciceri, Chiara Bonini, Monica Casucci, Beatrice Greco, Camilla Bove, Silvia Arcangeli, Laura Falcone, Rita El Khoury, Anna De Lucia

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Next-Generation Manufacturing Protocols Enriching TSCM CAR T Cells Can Overcome Disease-Specific T Cell Defects in Cancer Patients by Silvia Arcangeli, Laura Falcone, Barbara Camisa, Barbara Camisa, Federica De Girardi, Marta Biondi, Fabio Giglio, Fabio Ciceri, Fabio Ciceri, Chiara Bonini, Chiara Bonini, Attilio Bondanza, Monica Casucci

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Extracellular NGFR Spacers Allow Efficient Tracking and Enrichment of Fully Functional CAR-T Cells Co-Expressing a Suicide Gene by Monica Casucci, Laura Falcone, Barbara Camisa, Margherita Norelli, Simona Porcellini, Anna Stornaiuolo, Fabio Ciceri, Fabio Ciceri, Catia Traversari, Claudio Bordignon, Chiara Bonini, Chiara Bonini, Attilio Bondanza, Attilio Bondanza, Attilio Bondanza

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Efficacy of CAR-T immunotherapy in MET overexpressing tumors not eligible for anti-MET targeted therapy by Cristina Chiriaco, Chiara Donini, Marco Cortese, Stefano Ughetto, Chiara Modica, Ilaria Martinelli, Alessia Proment, Letizia Vitali, Lara Fontani, Monica Casucci, Paolo Maria Comoglio, Silvia Giordano, Dario Sangiolo, Valeria Leuci, Elisa Vigna

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306 N-glycosylation inhibition hinders immunosuppressive tumor microenvironment cells improving CAR T cell efficacy by Alice Bergamini, Barbara Camisa, Fabio Ciceri, Chiara Bonini, Monica Casucci, Beatrice Greco, Federica Pedica, Chiara Balestrieri, Laura Falcone, Miriam Redegalli, Elena Tiziano, Camilla Sirini, Giovanni Tonon, Rita El Khoury, Oronzina Botrugno

Myeloid cell‐based delivery of IFN‐γ reprograms the leukemia microenvironment and induces anti‐tumoral immune responses by Adele Mucci, Gabriele Antonarelli, Carolina Caserta, Francesco Maria Vittoria, Giacomo Desantis, Riccardo Pagani, Beatrice Greco, Monica Casucci, Giulia Escobar, Laura Passerini, Nico Lachmann, Francesca Sanvito, Matteo Barcella, Ivan Merelli, Luigi Naldini, Bernhard Gentner

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Human T cells engineered with a leukemia lipid-specific TCR enables donor-unrestricted recognition of CD1c-expressing leukemia by Michela Consonni, Claudio Garavaglia, Andrea Grilli, Claudia de Lalla, Alessandra Mancino, Lucia Mori, Gennaro De Libero, Daniela Montagna, Monica Casucci, Marta Serafini, Chiara Bonini, Daniel Häussinger, Fabio Ciceri, Massimo Bernardi, Sara Mastaglio, Silvio Bicciato, Paolo Dellabona, Giulia Casorati

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CAR T cell manufacturing from naive/stem memory T lymphocytes enhances antitumor responses while curtailing cytokine release syndrome by Silvia Arcangeli, Camilla Bove, Claudia Mezzanotte, Barbara Camisa, Laura Falcone, Francesco Manfredi, Eugenia Bezzecchi, Rita El Khoury, Rossana Norata, Francesca Sanvito, Maurilio Ponzoni, Beatrice Greco, Marta Angiola Moresco, Matteo G. Carrabba, Fabio Ciceri, Chiara Bonini, Attilio Bondanza, Monica Casucci

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226 ‘Off-the-shelf’ CD19-CAR-T cells generated from umbilical cord blood display superior anti-tumor fitness and lower pro-inflammatory activity as compared to peripheral blood-der... by Mohammed Toufiq, Damien Chaussabel, Suruchi Mohan, Cristina Maccalli, Asma Al Sulaiti, Chiara Bonini, Monica Casucci, Chiara Cugno, Sara Deola, Mohammed El Anbari, Shana Jacob, Saroja Kotegar Balayya, Salim Bougarn, Evonne Chin-Smith, Alex Issam Tout, Neha Gopinath, Damilola Olagunju

Case report: Ponatinib as a bridge to CAR-T cells and subsequent maintenance in a patient with relapsed/refractory Philadelphia-like acute lymphoblastic leukemia by Fabio Giglio, Fabio Giglio, Edoardo Campodonico, Edoardo Campodonico, Francesca Lorentino, Francesca Lorentino, Maddalena Noviello, Elisabetta Xue, Raffaella Greco, Lorenzo Lazzari, Alessandro Bruno, Maria Teresa Lupo Stanghellini, Matteo Giovanni Carrabba, Roberta La Starza, Monica Casucci, Chiara Bonini, Chiara Bonini, Sabina Chiaretti, Jacopo Peccatori, Robin Foà, Fabio Ciceri, Fabio Ciceri

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Bone marrow central memory and memory stem T-cell exhaustion in AML patients relapsing after HSCT by Maddalena Noviello, Francesco Manfredi, Eliana Ruggiero, Tommaso Perini, Giacomo Oliveira, Filippo Cortesi, Pantaleo De Simone, Cristina Toffalori, Valentina Gambacorta, Raffaella Greco, Jacopo Peccatori, Monica Casucci, Giulia Casorati, Paolo Dellabona, Masahiro Onozawa, Takanori Teshima, Marieke Griffioen, Constantijn J. M. Halkes, J. H. F. Falkenburg, Friedrich Stölzel, Heidi Altmann, Martin Bornhäuser, Miguel Waterhouse, Robert Zeiser, Jürgen Finke, Nicoletta Cieri, Attilio Bondanza, Luca Vago, Fabio Ciceri, Chiara Bonini

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