Identification and development of 2,3-dihydropyrrolo[1,2-a]quinazolin-5(1H)-one inhibitors targeting bromodomains within the switch/sucrose nonfermenting complex Por Sutherell, C, Tallant, C, Monteiro, O, Yapp, C, Fuchs, J, Fedorov, O, Siejka, P, Müller, S, Knapp, S, Brenton, J, Brennan, P, Ley, S

Identification and development of 2,3-dihydropyrrolo[1,2-a]quinazolin-5(1H)-one inhibitors targeting bromodomains within the switch/sucrose non-fermenting complex. Por Sutherell, C, Tallant, C, Monteiro, O, Yapp, C, Fuchs, J, Fedorov, O, Siejka, P, Müller, S, Knapp, S, Brenton, J, Brennan, P, Ley, S

A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain Por Cox, O, Krojer, T, Collins, P, Monteiro, O, Talon, R, Bradley, A, Fedorov, O, Amin, J, Marsden, B, Spencer, J, von Delft, F, Brennan, P

Discovery of a novel allosteric inhibitor scaffold for polyadenosine-diphosphate-ribose polymerase 14 (PARP14) macrodomain 2 Por Moustakim, M, Riedel, K, Schuller, M, Gehring, A, Monteiro, O, Martin, S, Fedorov, O, Heer, J, Dixon, D, Elkins, J, Knapp, S, Bracher, F, Brennan, P

[1,2,4]triazolo[4,3-a]phthalazines: inhibitors of diverse bromodomains. Por Fedorov, O, Lingard, H, Wells, C, Monteiro, O, Picaud, S, Keates, T, Yapp, C, Philpott, M, Martin, S, Felletar, I, Marsden, B, Filippakopoulos, P, Müller, S, Knapp, S, Brennan, P

Discovery of a selective inhibitor for the YEATS domains of ENL/AF9 Por Christott, T, Bennett, J, Coxon, C, Monteiro, O, Giroud, C, Beke, V, Felce, S, Gamble, V, Gileadi, C, Poda, G, Al-Awar, R, Farnie, G, Fedorov, O

An activity-based probe targeting non-catalytic, highly conserved amino acid residues within bromodomains Por D'Ascenzio, M, Pugh, KM, Konietzny, R, Berridge, G, Tallant, C, Hashem, S, Monteiro, O, Thomas, JR, Schirle, M, Knapp, S, Marsden, B, Fedorov, O, Bountra, C, Kessler, BM, Brennan, PE

Chemical probes for bromodomains outside the BET family Por Brennan, P, Martin, S, Monteiro, O, Fedorov, O, Knapp, S, Hay, D, Wells, C, Filippakopoulos, P, Picaud, S, Muller-Knapp, S, Keates, T, Yapp, C, Philpott, M, Schofield, C, Burgess-Brown, N, Shrestha, L, Strain-Damerell, C

Discovery and Optimization of Small-Molecule Ligands for the CBP/p300 Bromodomains Por Hay, D, Fedorov, O, Martin, S, Singleton, D, Tallant, C, Wells, C, Picaud, S, Philpott, M, Monteiro, O, Rogers, C, Conway, S, Rooney, T, Tumber, A, Yapp, C, Filippakopoulos, P, Bunnage, M, Müller, S, Knapp, S, Schofield, C, Brennan, P

BET inhibition as a new strategy for the treatment of gastric cancer Por Montenegro, R, Clark, P, Howarth, A, Wan, X, Ceroni, A, Siejka, P, Nunez-Alonso, G, Monteiro, O, Rogers, C, Gamble, V, Burbano, R, Brennan, P, Tallant, C, Ebner, D, Fedorov, O, O'Neill, E, Knapp, S, Dixon, D, Müller, S

Benzoisoquinolinediones as potent and selective inhibitors of BRPF2 and TAF1/TAF1L bromodomains Por Bouché, L, Christ, C, Siegel, S, Fernández-Montalván, A, Holton, S, Fedorov, O, Ter Laak, A, Sugawara, T, Stöckigt, D, Tallant, C, Bennett, J, Monteiro, O, Díaz-Sáez, L, Siejka, P, Meier, J, Pütter, V, Weiske, J, Müller, S, Huber, K, Hartung, I, Haendler, B

Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance. Por Fedorov, O, Castex, J, Tallant, C, Owen, D, Martin, S, Aldeghi, M, Monteiro, O, Filippakopoulos, P, Picaud, S, Trzupek, J, Gerstenberger, B, Bountra, C, Willmann, D, Wells, C, Philpott, M, Rogers, C, Biggin, P, Brennan, P, Bunnage, M, Schüle, R, Günther, T, Knapp, S, Müller, S

Promiscuous targeting of bromodomains by Bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia Por Picaud, S, Leonards, K, Lambert, J, Dovey, O, Wells, C, Fedorov, O, Monteiro, O, Fujisawa, T, Wang, C, Lingard, H, Tallant, C, Nikbin, N, Guetzoyan, L, Ingham, R, Ley, S, Brennan, P, Muller, S, Samsonova, A, Gingras, A, Schwaller, J, Vassiliou, G, Knapp, S, Filippakopoulos, P

Discovery of a PCAF bromodomain chemical probe Por Moustakim, M, Clark, P, Trulli, L, Fuentes de Arriba, A, Ehebauer, M, Chaikuad, A, Murphy, E, Mendez-Johnson, J, Daniels, D, Hou, C, Lin, Y, Walker, J, Hui, R, Yang, H, Dorrell, L, Rogers, C, Monteiro, O, Fedorov, O, Huber, K, Knapp, S, Heer, J, Dixon, D, Brennan, P

Discovery of an MLLT1/3 YEATS domain chemical probe Por Moustakim, M, Christott, T, Monteiro, O, Bennett, J, Giroud, C, Ward, J, Rogers, C, Smith, P, Panagakou, I, Saez, L, Felce, S, Gamble, V, Gileadi, C, Halidi, N, Heidenreich, D, Chaikuad, A, Knapp, S, Huber, K, Farnie, G, Heer, J, Manevski, N, Poda, G, Al-Awar, R, Dixon, D, Fedorov, O, Brennan, P

A chemical probe for Tudor domain protein spindlin1 to investigate chromatin function Por Fagan, V, Johansson, C, Gileadi, C, Monteiro, O, Dunford, J, Nibhani, R, Philpott, M, Malzahn, J, Wells, G, Farham, R, Cribbs, A, Halidi, N, Li, F, Chau, I, Greschik, H, Velupillai, S, Allali-Hassani, A, Bennett, J, Christott, T, Giroud, C, Lewis, A, Huber, K, Athanasou, N, Bountra, C, Jung, M, Schüle, R, Vedadi, M, Arrowsmith, C, Xiong, Y, Jin, J, Fedorov, O, Farnie, G, Brennan, P, Oppermann, U

Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy Por Picaud, S, Fedorov, O, Thanasopoulou, A, Leonards, K, Jones, K, Meier, J, Olzscha, H, Monteiro, O, Martin, S, Philpott, M, Tumber, A, Filippakopoulos, P, Yapp, C, Wells, C, Che, K, Bannister, A, Robson, S, Kumar, U, Parr, N, Lee, K, Lugo, D, Jeffrey, P, Taylor, S, Vecellio, M, Bountra, C, Brennan, P, O'Mahony, A, Velichko, S, Müller, S, Hay, D, Daniels, D, Urh, M, La Thangue, N, Kouzarides, T, Prinjha, R, Schwaller, J, Knapp, S