1435 Interleukin-8 activates fibroblast and could act as a potential combinational immune-stroma therapy target by Nicholas Willumsen, Neel Nissen, Morten A Karsdal

Changes in type VI collagen degradation reflect clinical response to treatment in rheumatoid arthritis patients treated with tocilizumab by Christian S. Thudium, Peder Frederiksen, Morten A. Karsdal, Anne-Christine Bay-Jensen

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Association between type III collagen degradation and local tissue damage of a single joint by Christian S. Thudium, Sten Rasmussen, Morten A. Karsdal, Anne-Christine Bay-Jensen

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36 Degradation of type III and IV collagen associates with outcome when measured in serum from patients with metastatic melanoma treated with immune checkpoint inhibitors by Marco Donia, Christina Jensen, Nicholas Willumsen, Inge Svane, Anders Kverneland, Morten A Karsdal

The fibroid phenotype of biological naïve patients with rheumatoid arthritis are less likely to respond to anti-IL-6R treatment by Sofie Falkenløve Madsen, Dovile Sinkeviciute, Christian S. Thudium, Morten A. Karsdal, Anne-Christine Bay-Jensen

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37 Collagen remodeling biomarkers in patients with locally advanced pancreatic cancer treated with stereotactic body radiotherapy plus intradermal heat-killed mycobacterium obuense... by Christina Jensen, Nicholas Willumsen, Morten A Karsdal, Freek R van’t Land, Casper HJ van Eijck

Age-related collagen turnover of the interstitial matrix and basement membrane: Implications of age- and sex-dependent remodeling of the extracellular matrix. by Stephanie N Kehlet, Nicholas Willumsen, Gabriele Armbrecht, Roswitha Dietzel, Susanne Brix, Kim Henriksen, Morten A Karsdal

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Pathological tissue formation and degradation biomarkers correlate with patient reported pain outcomes: an explorative study by Anne C. Bay-Jensen, Mukundan Attur, Jonathan Samuels, Christian S. Thudium, Steven B. Abramson, Morten A. Karsdal

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Endotrophin, a fibroblast matrikine, may be a driver of fibroblast activation in fibro-inflammatory diseases by Alexander L. Reese-Petersen, Federica Genovese, Lei Zhao, Glen Banks, David A. Gordon, Morten A. Karsdal

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Intermittent Dynamic Compression Confers Anabolic Effects in Articular Cartilage by Amalie Engstrøm, Frederik S. Gillesberg, Solveig S. Groen, Peder Frederiksen, Anne-Christine Bay-Jensen, Morten A. Karsdal, Christian S. Thudium

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Distribution, Size, and Shape of Abdominal Aortic Calcified Deposits and Their Relationship to Mortality in Postmenopausal Women by Melanie Ganz, Marleen de Bruijne, Erik B. Dam, Paola Pettersen, Morten A. Karsdal, Claus Christiansen, Mads Nielsen

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Biomarkers of Type IV Collagen Turnover Reflect Disease Activity in Patients with Early-Stage Non-Alcoholic Fatty Liver (NAFL) by Ida Lønsmann, Jane I. Grove, Asma Haider, Philip Kaye, Morten A. Karsdal, Diana J. Leeming, Guruprasad P. Aithal

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Endotrophin is a risk marker of complications in CANagliflozin cardioVascular Assessment Study (CANVAS): a randomized controlled trial by Daniel Guldager Kring Rasmussen, Michael K. Hansen, Joseph Blair, Timothy A. Jatkoe, Bruce Neal, Morten A. Karsdal, Federica Genovese

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P153 MARKER OF TYPE VI COLLAGEN FORMATION (PRO-C6) IS ASSOCIATED WITH HIGHER ARTERIAL STIFFNESS IN TYPE 1 DIABETES by Tine Willum Hansen, Daniel G.K. Rasmussen, Simone Theilade, Signe H. Nielsen, Morten A. Karsdal, Federica Genovese, Peter Rossing

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Osteoclasts are not crucial for hematopoietic stem cell maintenance in adult mice by Carmen Flores, Ilana Moscatelli, Christian S. Thudium, Natasja Stæhr Gudmann, Jesper S. Thomsen, Annemarie Brüel, Morten A. Karsdal, Kim Henriksen, Johan Richter

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Collagen turnover is associated with cardiovascular autonomic and peripheral neuropathy in type 1 diabetes: novel pathophysiological mechanism? by Christian S. Hansen, Daniel G. K. Rasmussen, Tine W. Hansen, Signe Holm Nielsen, Simone Theilade, Morten A. Karsdal, Federica Genovese, Peter Rossing

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The Janus kinase 1/2 inhibitor baricitinib reduces biomarkers of joint destruction in moderate to severe rheumatoid arthritis by Christian S. Thudium, Anne C. Bay-Jensen, Suntara Cahya, Ernst R. Dow, Morten A. Karsdal, Alisa E. Koch, Wenling Zhang, Robert J. Benschop

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Association between Markers of Synovial Inflammation, Matrix Turnover and Symptoms in Knee Osteoarthritis: A Cross-Sectional Study by Xiaotian Yang, Christian S. Thudium, Anne-Christine Bay-Jensen, Morten A. Karsdal, James van Santen, Nigel K. Arden, Thomas A. Perry, Stefan Kluzek

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Markers of Collagen Remodeling Detect Clinically Significant Fibrosis in Chronic Hepatitis C Patients. by Mette J Nielsen, Konstantin Kazankov, Diana J Leeming, Morten A Karsdal, Aleksander Krag, Francisco Barrera, Duncan McLeod, Jacob George, Henning Grønbæk

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Levels of type XVII collagen (BP180) ectodomain are elevated in circulation from patients with multiple cancer types and is prognostic for patients with metastatic colorectal cance... by Marina Crespo-Bravo, Jeppe Thorlacius-Ussing, Neel I. Nissen, Rasmus S. Pedersen, Mogens K. Boisen, Maria Liljefors, Astrid Z. Johansen, Julia S. Johansen, Morten A. Karsdal, Nicholas Willumsen

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