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Constitutive activation and oncogenicity are mediated by loss of helical structure at the cytosolic boundary of thrombopoietin receptor mutant dimers by Defour, J-P, Leroy, E, Dass, S, Balligand, T, Levy, G, Brett, IC, Papadopoulos, N, Mouton, C, Genet, L, Pecquet, C, Staerk, J, Smith, SO, Constantinescu, SN