Well-ordered trimeric HIV-1 subtype B and C soluble spike mimetics generated by negative selection display native-like properties. av Javier Guenaga, Natalia de Val, Karen Tran, Yu Feng, Karen Satchwell, Andrew B Ward, Richard T Wyatt

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Cleavage-Independent HIV-1 Env Trimers Engineered as Soluble Native Spike Mimetics for Vaccine Design av Shailendra Kumar Sharma, Natalia de Val, Shridhar Bale, Javier Guenaga, Karen Tran, Yu Feng, Viktoriya Dubrovskaya, Andrew B. Ward, Richard T. Wyatt

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Hidden Lineage Complexity of Glycan-Dependent HIV-1 Broadly Neutralizing Antibodies Uncovered by Digital Panning and Native-Like gp140 Trimer av Linling He, Xiaohe Lin, Natalia de Val, Natalia de Val, Natalia de Val, Karen L. Saye-Francisco, Karen L. Saye-Francisco, Colin J. Mann, Ryan Augst, Charles D. Morris, Parisa Azadnia, Bin Zhou, Devin Sok, Devin Sok, Devin Sok, Gabriel Ozorowski, Gabriel Ozorowski, Gabriel Ozorowski, Andrew B. Ward, Andrew B. Ward, Andrew B. Ward, Dennis R. Burton, Dennis R. Burton, Dennis R. Burton, Dennis R. Burton, Jiang Zhu, Jiang Zhu, Jiang Zhu

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Targeted N-glycan deletion at the receptor-binding site retains HIV Env NFL trimer integrity and accelerates the elicited antibody response. av Viktoriya Dubrovskaya, Javier Guenaga, Natalia de Val, Richard Wilson, Yu Feng, Arlette Movsesyan, Gunilla B Karlsson Hedestam, Andrew B Ward, Richard T Wyatt

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Improved Retinal Organoid Differentiation by Modulating Signaling Pathways Revealed by Comparative Transcriptome Analyses with Development In Vivo av Matthew J. Brooks, Holly Y. Chen, Ryan A. Kelley, Anupam K. Mondal, Kunio Nagashima, Natalia De Val, Tiansen Li, Vijender Chaitankar, Anand Swaroop

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Thermostability of Well-Ordered HIV Spikes Correlates with the Elicitation of Autologous Tier 2 Neutralizing Antibodies. av Yu Feng, Karen Tran, Shridhar Bale, Shailendra Kumar, Javier Guenaga, Richard Wilson, Natalia de Val, Heather Arendt, Joanne DeStefano, Andrew B Ward, Richard T Wyatt

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Cryo-EM structure of substrate-free E. coli Lon protease provides insights into the dynamics of Lon machinery av Istvan Botos, George T. Lountos, Weimin Wu, Scott Cherry, Rodolfo Ghirlando, Arsen M. Kudzhaev, Tatyana V. Rotanova, Natalia de Val, Joseph E. Tropea, Alla Gustchina, Alexander Wlodawer

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Structural Studies Reveal the Role of Helix 68 in the Elongation Step of Protein Biosynthesis av Giuseppe Cimicata, Gil Fridkin, Tanaya Bose, Zohar Eyal, Yehuda Halfon, Elinor Breiner-Goldstein, Tara Fox, Ella Zimmerman, Anat Bashan, Natalia de Val, Alexander Wlodawer, Ada Yonath

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Zika Virus-Induced Neuronal Apoptosis via Increased Mitochondrial Fragmentation av Shu Yang, Kirill Gorshkov, Emily M. Lee, Miao Xu, Yu-Shan Cheng, Nuo Sun, Ferri Soheilian, Natalia de Val, Guoli Ming, Hongjun Song, Hengli Tang, Wei Zheng

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Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability av Leopold Kong, Linling He, Natalia de Val, Nemil Vora, Charles D. Morris, Parisa Azadnia, Devin Sok, Bin Zhou, Dennis R. Burton, Andrew B. Ward, Ian A. Wilson, Jiang Zhu

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The IgG4 hinge with CD28 transmembrane domain improves VHH-based CAR T cells targeting a membrane-distal epitope of GPC1 in pancreatic cancer av Nan Li, Alex Quan, Dan Li, Jiajia Pan, Hua Ren, Gerard Hoeltzel, Natalia de Val, Dana Ashworth, Weiming Ni, Jing Zhou, Sean Mackay, Stephen M. Hewitt, Raul Cachau, Mitchell Ho

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Structure-Guided Redesign Improves NFL HIV Env Trimer Integrity and Identifies an Inter-Protomer Disulfide Permitting Post-Expression Cleavage av Lifei Yang, Shailendra Kumar Sharma, Christopher Cottrell, Javier Guenaga, Karen Tran, Richard Wilson, Anna-Janina Behrens, Max Crispin, Max Crispin, Max Crispin, Natalia de Val, Richard T. Wyatt, Richard T. Wyatt, Richard T. Wyatt

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Murine anti-vaccinia virus D8 antibodies target different epitopes and differ in their ability to block D8 binding to CS-E. av Michael H Matho, Natalia de Val, Gregory M Miller, Joshua Brown, Andrew Schlossman, Xiangzhi Meng, Shane Crotty, Bjoern Peters, Yan Xiang, Linda C Hsieh-Wilson, Andrew B Ward, Dirk M Zajonc

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Presenting native-like trimeric HIV-1 antigens with self-assembling nanoparticles av Linling He, Natalia de Val, Charles D. Morris, Nemil Vora, Therese C. Thinnes, Leopold Kong, Parisa Azadnia, Devin Sok, Bin Zhou, Dennis R. Burton, Ian A Wilson, David Nemazee, Andrew B. Ward, Jiang Zhu

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Reserpine maintains photoreceptor survival in retinal ciliopathy by resolving proteostasis imbalance and ciliogenesis defects av Holly Y Chen, Manju Swaroop, Samantha Papal, Anupam K Mondal, Hyun Beom Song, Laura Campello, Gregory J Tawa, Florian Regent, Hiroko Shimada, Kunio Nagashima, Natalia de Val, Samuel G Jacobson, Wei Zheng, Anand Swaroop

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Structure of a cleavage-independent HIV Env recapitulates the glycoprotein architecture of the native cleaved trimer av Anita Sarkar, Shridhar Bale, Anna-Janina Behrens, Sonu Kumar, Shailendra Kumar Sharma, Natalia de Val, Jesper Pallesen, Adriana Irimia, Devan C. Diwanji, Robyn L. Stanfield, Andrew B. Ward, Max Crispin, Richard T. Wyatt, Ian A. Wilson

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Rational Design of DNA-Expressed Stabilized Native-Like HIV-1 Envelope Trimers av Yoann Aldon, Paul F. McKay, Joel Allen, Gabriel Ozorowski, Réka Felfödiné Lévai, Monica Tolazzi, Paul Rogers, Linling He, Natalia de Val, Katalin Fábián, Gabriella Scarlatti, Jiang Zhu, Andrew B. Ward, Max Crispin, Robin J. Shattock

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Differential Antibody Responses to Conserved HIV-1 Neutralizing Epitopes in the Context of Multivalent Scaffolds and Native-Like gp140 Trimers av Charles D. Morris, Parisa Azadnia, Natalia de Val, Nemil Vora, Andrew Honda, Erick Giang, Karen Saye-Francisco, Yushao Cheng, Xiaohe Lin, Colin J. Mann, Jeffrey Tang, Devin Sok, Dennis R. Burton, Mansun Law, Andrew B. Ward, Linling He, Jiang Zhu

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Elicitation of Neutralizing Antibodies Targeting the V2 Apex of the HIV Envelope Trimer in a Wild-Type Animal Model av James E. Voss, Raiees Andrabi, Laura E. McCoy, Natalia de Val, Roberta P. Fuller, Terrence Messmer, Ching-Yao Su, Devin Sok, Salar N. Khan, Fernando Garces, Laura K. Pritchard, Richard T. Wyatt, Andrew B. Ward, Max Crispin, Ian A. Wilson, Dennis R. Burton

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Elicitation of Neutralizing Antibodies Targeting the V2 Apex of the HIV Envelope Trimer in a Wild-Type Animal Model av James E. Voss, Raiees Andrabi, Laura E. McCoy, Natalia de Val, Roberta P. Fuller, Terrence Messmer, Ching-Yao Su, Devin Sok, Salar N. Khan, Fernando Garces, Laura K. Pritchard, Richard T. Wyatt, Andrew B. Ward, Max Crispin, Ian A. Wilson, Dennis R. Burton

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