Evolutionary signatures amongst disease genes permit novel methods for gene prioritization and construction of informative gene-based networks. by Nolan Priedigkeit, Nicholas Wolfe, Nathan L Clark

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Evolutionary rate covariation is a reliable predictor of co-functional interactions but not necessarily physical interactions by Jordan Little, Maria Chikina, Nathan L Clark

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Pan-mammalian analysis of molecular constraints underlying extended lifespan by Amanda Kowalczyk, Raghavendran Partha, Nathan L Clark, Maria Chikina

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Experimental exchange of paralogous domains in the MLH family provides evidence of sub-functionalization after gene duplication by Christopher M Furman, Ryan Elbashir, Gianno Pannafino, Nathan L Clark, Eric Alani

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Evolutionary rate covariation is pervasive between glycosylation pathways and points to potential disease modifiers. by Holly J Thorpe, Raghavendran Partha, Jordan Little, Nathan L Clark, Clement Y Chow

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Activation by cleavage of the epithelial Na+ channel α and γ subunits independently coevolved with the vertebrate terrestrial migration by Xue-Ping Wang, Deidra M Balchak, Clayton Gentilcore, Nathan L Clark, Ossama B Kashlan

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Overlapping Patterns of Rapid Evolution in the Nucleic Acid Sensors cGAS and OAS1 Suggest a Common Mechanism of Pathogen Antagonism and Escape. by Dustin C Hancks, Melissa K Hartley, Celia Hagan, Nathan L Clark, Nels C Elde

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Evolutionary rate covariation identifies new members of a protein network required for Drosophila melanogaster female post-mating responses. by Geoffrey D Findlay, Jessica L Sitnik, Wenke Wang, Charles F Aquadro, Nathan L Clark, Mariana F Wolfner

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Subterranean mammals show convergent regression in ocular genes and enhancers, along with adaptation to tunneling by Raghavendran Partha, Bharesh K Chauhan, Zelia Ferreira, Joseph D Robinson, Kira Lathrop, Ken K Nischal, Maria Chikina, Nathan L Clark

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Evolutionary rate covariation analysis of E-cadherin identifies Raskol as a regulator of cell adhesion and actin dynamics in Drosophila. by Qanber Raza, Jae Young Choi, Yang Li, Roisin M O'Dowd, Simon C Watkins, Maria Chikina, Yang Hong, Nathan L Clark, Adam V Kwiatkowski

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A Drosophila screen identifies NKCC1 as a modifier of NGLY1 deficiency by Dana M Talsness, Katie G Owings, Emily Coelho, Gaelle Mercenne, John M Pleinis, Raghavendran Partha, Kevin A Hope, Aamir R Zuberi, Nathan L Clark, Cathleen M Lutz, Aylin R Rodan, Clement Y Chow

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MCM8IP activates the MCM8-9 helicase to promote DNA synthesis and homologous recombination upon DNA damage by Jen-Wei Huang, Ananya Acharya, Angelo Taglialatela, Tarun S. Nambiar, Raquel Cuella-Martin, Giuseppe Leuzzi, Samuel B. Hayward, Sarah A. Joseph, Gregory J. Brunette, Roopesh Anand, Rajesh K. Soni, Nathan L. Clark, Kara A. Bernstein, Petr Cejka, Alberto Ciccia

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Multiple 9-1-1 complexes promote homolog synapsis, DSB repair, and ATR signaling during mammalian meiosis by Catalina Pereira, Gerardo A Arroyo-Martinez, Matthew Z Guo, Michael S Downey, Emma R Kelly, Kathryn J Grive, Shantha K Mahadevaiah, Jennie R Sims, Vitor M Faca, Charlton Tsai, Carl J Schiltz, Niek Wit, Heinz Jacobs, Nathan L Clark, Raimundo Freire, James Turner, Amy M Lyndaker, Miguel A Brieno-Enriquez, Paula E Cohen, Marcus B Smolka, Robert S Weiss

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