Down-Regulation of AKT Proteins Slows the Growth of Mutant-KRAS Pancreatic Tumors by Chuankai Chen, Ya-Ping Jiang, Inchul You, Nathanael S. Gray, Richard Z. Lin

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Dual inhibition of Fes and Flt3 tyrosine kinases potently inhibits Flt3-ITD+ AML cell growth. by Mark C Weir, Sabine Hellwig, Li Tan, Yao Liu, Nathanael S Gray, Thomas E Smithgall

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Systematic analysis of BRAFV600E melanomas reveals a role for JNK/c‐Jun pathway in adaptive resistance to drug‐induced apoptosis by Mohammad Fallahi‐Sichani, Nathan J Moerke, Mario Niepel, Tinghu Zhang, Nathanael S Gray, Peter K Sorger

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How small-molecule inhibitors of dengue-virus infection interfere with viral membrane fusion by Luke H Chao, Jaebong Jang, Adam Johnson, Anthony Nguyen, Nathanael S Gray, Priscilla L Yang, Stephen C Harrison

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Tubulin Resists Degradation by Cereblon-Recruiting PROTACs by Ivana Gasic, Brian J. Groendyke, Radosław P. Nowak, J. Christine Yuan, Joann Kalabathula, Eric S. Fischer, Nathanael S. Gray, Timothy J. Mitchison

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Microenvironmental influence on pre-clinical activity of polo-like kinase inhibition in multiple myeloma: implications for clinical translation. by Douglas W McMillin, Jake Delmore, Joseph Negri, Melissa Ooi, Steffen Klippel, Chandrasekhar V Miduturu, Nathanael S Gray, Paul G Richardson, Kenneth C Anderson, Andrew L Kung, Constantine S Mitsiades

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Broad-spectrum activity against mosquito-borne flaviviruses achieved by a targeted protein degradation mechanism by Han-Yuan Liu, Zhengnian Li, Theresia Reindl, Zhixiang He, Xueer Qiu, Ryan P. Golden, Katherine A. Donovan, Adam Bailey, Eric S. Fischer, Tinghu Zhang, Nathanael S. Gray, Priscilla L. Yang

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Identification of Novel Small Molecule Inhibitors of Oncogenic RET Kinase. by Marialuisa Moccia, Qingsong Liu, Teresa Guida, Giorgia Federico, Annalisa Brescia, Zheng Zhao, Hwan Geun Choi, Xianming Deng, Li Tan, Jinhua Wang, Marc Billaud, Nathanael S Gray, Francesca Carlomagno, Massimo Santoro

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Molecular Bidents with Two Electrophilic Warheads as a New Pharmacological Modality by Zhengnian Li, Jie Jiang, Scott B. Ficarro, Tyler S. Beyett, Ciric To, Isidoro Tavares, Yingde Zhu, Jiaqi Li, Michael J. Eck, Pasi A. Jänne, Jarrod A. Marto, Tinghu Zhang, Jianwei Che, Nathanael S. Gray

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Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors by Tyler S. Beyett, Ciric To, David E. Heppner, Jaimin K. Rana, Anna M. Schmoker, Jaebong Jang, Dries J. H. De Clercq, Gabriel Gomez, David A. Scott, Nathanael S. Gray, Pasi A. Jänne, Michael J. Eck

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Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models by M Catarina Silva, Fleur M Ferguson, Quan Cai, Katherine A Donovan, Ghata Nandi, Debasis Patnaik, Tinghu Zhang, Hai-Tsang Huang, Diane E Lucente, Bradford C Dickerson, Timothy J Mitchison, Eric S Fischer, Nathanael S Gray, Stephen J Haggarty

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MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells by Yubao Wang, Young-Mi Lee, Lukas Baitsch, Alan Huang, Yi Xiang, Haoxuan Tong, Ana Lako, Thanh Von, Christine Choi, Elgene Lim, Junxia Min, Li Li, Frank Stegmeier, Robert Schlegel, Michael J Eck, Nathanael S Gray, Timothy J Mitchison, Jean J Zhao

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Correction: MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells by Yubao Wang, Young-Mi Li, Lukas Baitsch, Alan Huang, Yi Xiang, Haoxuan Tong, Ana Lako, Thanh Von, Christine Choi, Elgene Lim, Junxia Min, Li Li, Frank Stegmeier, Robert Schlegel, Michael J Eck, Nathanael S Gray, Timothy J Mitchison, Jean J Zhao

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Discovery of Potent Degraders of the Dengue Virus Envelope Protein by Zhengnian Li, Han‐Yuan Liu, Zhixiang He, Antara Chakravarty, Ryan P. Golden, Zixuan Jiang, Inchul You, Hong Yue, Katherine A. Donovan, Guangyan Du, Jianwei Che, Jason Tse, Isaac Che, Wenchao Lu, Eric S. Fischer, Tinghu Zhang, Nathanael S. Gray, Priscilla L. Yang

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Targeting transcription in heart failure via CDK7/12/13 inhibition by Austin Hsu, Qiming Duan, Daniel S. Day, Xin Luo, Sarah McMahon, Yu Huang, Zachary B. Feldman, Zhen Jiang, Tinghu Zhang, Yanke Liang, Michael Alexanian, Arun Padmanabhan, Jonathan D. Brown, Charles Y. Lin, Nathanael S. Gray, Richard A. Young, Benoit G. Bruneau, Saptarsi M. Haldar

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MELK is not necessary for the proliferation of basal-like breast cancer cells by Hai-Tsang Huang, Hyuk-Soo Seo, Tinghu Zhang, Yubao Wang, Baishan Jiang, Qing Li, Dennis L Buckley, Behnam Nabet, Justin M Roberts, Joshiawa Paulk, Shiva Dastjerdi, Georg E Winter, Hilary McLauchlan, Jennifer Moran, James E Bradner, Michael J Eck, Sirano Dhe-Paganon, Jean J Zhao, Nathanael S Gray

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Targeting MYC dependency in ovarian cancer through inhibition of CDK7 and CDK12/13 by Mei Zeng, Nicholas P Kwiatkowski, Tinghu Zhang, Behnam Nabet, Mousheng Xu, Yanke Liang, Chunshan Quan, Jinhua Wang, Mingfeng Hao, Sangeetha Palakurthi, Shan Zhou, Qing Zeng, Paul T Kirschmeier, Khyati Meghani, Alan L Leggett, Jun Qi, Geoffrey I Shapiro, Joyce F Liu, Ursula A Matulonis, Charles Y Lin, Panagiotis A Konstantinopoulos, Nathanael S Gray

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Covalent disruptor of YAP-TEAD association suppresses defective Hippo signaling by Mengyang Fan, Wenchao Lu, Jianwei Che, Nicholas P Kwiatkowski, Yang Gao, Hyuk-Soo Seo, Scott B Ficarro, Prafulla C Gokhale, Yao Liu, Ezekiel A Geffken, Jimit Lakhani, Kijun Song, Miljan Kuljanin, Wenzhi Ji, Jie Jiang, Zhixiang He, Jason Tse, Andrew S Boghossian, Matthew G Rees, Melissa M Ronan, Jennifer A Roth, Joseph D Mancias, Jarrod A Marto, Sirano Dhe-Paganon, Tinghu Zhang, Nathanael S Gray

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Reciprocal antagonism of PIN1-APC/CCDH1 governs mitotic protein stability and cell cycle entry by Shizhong Ke, Fabin Dang, Lin Wang, Jia-Yun Chen, Mandar T. Naik, Wenxue Li, Abhishek Thavamani, Nami Kim, Nandita M. Naik, Huaxiu Sui, Wei Tang, Chenxi Qiu, Kazuhiro Koikawa, Felipe Batalini, Emily Stern Gatof, Daniela Arango Isaza, Jaymin M. Patel, Xiaodong Wang, John G. Clohessy, Yujing J. Heng, Galit Lahav, Yansheng Liu, Nathanael S. Gray, Xiao Zhen Zhou, Wenyi Wei, Gerburg M. Wulf, Kun Ping Lu

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Dual targeting of salt inducible kinases and CSF1R uncouples bone formation and bone resorption by Cheng-Chia Tang, Christian D Castro Andrade, Maureen J O'Meara, Sung-Hee Yoon, Tadatoshi Sato, Daniel J Brooks, Mary L Bouxsein, Janaina da Silva Martins, Jinhua Wang, Nathanael S Gray, Barbara Misof, Paul Roschger, Stephane Blouin, Klaus Klaushofer, Annegreet Velduis-Vlug, Yosta Vegting, Clifford J Rosen, Daniel O'Connell, Thomas B Sundberg, Ramnik J Xavier, Peter Ung, Avner Schlessinger, Henry M Kronenberg, Rebecca Berdeaux, Marc Foretz, Marc N Wein

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